Description overdue on 10/20/2014
- Latin name: Trachisan
- ATC code: R02AB52
- Active substance: Tyrothricin + Lidocaine + Chlorhexidine digluconate (Tyrothricin + Lidocaine Hydrochloride + Chlorhexidine Bigluconate)
- Manufacturer: Engelhard Arzneimittel (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Tablets Trachisan, instructions for use
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
Composition
The composition of one tablet comprises the following pharmaceutically active agents: 0, 5 mg tyrothricin 1, 0 mg chlorhexidine bigluconate 1, 0 mg lidocaine hydrochloride .
As additional ingredients are such substances as magnesium stearate, sorbitol, and peppermint oil.
Product form
Lozenges Trachisan packed 10 pieces in blisters made of PVC film and aluminum foil. The contour of the package 2 pieces and detailed instructions on Trachisan in turn placed into cardboard boxes.
Pharmacological action
Lozenges Trachisan are combined with synthetic drug, the pharmacological effect is determined by a unique topical antibiotic tyrothricin , Antiseptic chlorhexidine and anesthetic lidocaine .
Due to an optimum combination of these components tablets Trachisan provide both anti-inflammatory, and antimicrobial and analgesic effect.
Pharmacodynamics and pharmacokinetics
Pharmacokinetics
Tyrothricin It can be destroyed by gastric juice, so when taken regularly without the drug in violation of the regime and compliance doses pharmacologically relevant concentrations occur in the serum should not.
Lidocaine hydrochloride It acts very quickly and its protein binding is approximately 60 to 80% and the last half-life of 1 to 2 hours.
High activity when administered orally shows chlorhexidine in the digestive tract. Resorption of the antiseptic process is quite long, as well as half-life, which is 4 days.
Pharmacodynamics
Part tyrothricin includes cyclic and linear (alifatichnye) polypeptides that possess antibacterial properties and are very similar in structure to endotoxins such class spore as Bacille brevis .
Tirotsidin can trigger the release of substances that contain substances such as nitrogen and phosphorus Which in turn promote destruction of the osmotic barrier membrane of the bacterial cell.
Gramicidin cation promotes the formation of conducting channels in the cell membranes of bacteria that can cause serious changes in the concentration of cations and cytolysis. Due gramitsidinovogo component separation can occur as a process of tissue respiration and oxidative phosphorylation.
Please note that under the sphere of influence tyrothricin Gram-positive cocci mostly fall, as well as various species of fungi, including Candida albicans .
If we compare tyrothricin with other antibiotics, it is the lack of cross-resistance of microorganisms.
Effectiveness chlorhexidine It based on its close relationship with cell membrane of microorganisms. The fact is that it tends to change after direct contact with any active substance. Thus, chlorhexidine capable disrupt osmotic balance within the cell that results in complete or partial destruction of a cytoplasmic cell membrane of the pathogen.
Lidocaine hydrochloride blocking sodium channels of nerve fibers which results in disruption of membrane depolarization of nerve cells via an active potential.
Note also the fact that long-term use of the drug efficacy can be greatly reduced.
Indications
It is recommended to take lozenges Trachisan:
- inflammatory and infectious diseases of the oral cavity and pharynx ( stomatitis, gingivitis, periodontitis, glossitis, tonsillitis, pharyngitis and other conditions involving difficulties in swallowing);
- in the prevention of infections, both before and after surgery in the oral cavity and pharynx (dental extractions, surgical treatment of gum tonsillectomy ).
Contraindications
It is not recommended to take the drug Trachisan:
- hypersensitivity to any of the ingredients of the formulation;
- when damaged oral mucosa (erosion);
- open wounds in the oral and pharyngeal cavity;
- in children younger than 6 years.
Side effects
During the course of treatment Trachisan patient may experience discomfort:
- from short-term changes in taste, numbness of the tongue, which extend a short time;
- slight staining on the yellow or pale brown tint to the teeth, prostheses or dental fillings, is eliminated by proper oral hygiene.
Tablets Trachisan, instructions for use
Lozenges Trachisan you must take 1 tablet for every 2 hours. The daily dose for adults and children and adolescents over 12 years old should not exceed 8 tablets, and for children who have not yet reached the age of 12 years - 6 tablets.
Symptoms completely recede within a few days, but in order to achieve lasting therapeutic effect, experts advise taking the drug to extend for another 2 - 4 days. If after 5-7 days of therapy improvement is not forthcoming, you should always consult your doctor and make a change in the treatment regimen.
Overdose
If you accidentally taking an excessive amount of the drug is recommended to carry out the procedure Trachisan gastric lavage .
Cooperation
Hitherto these have on the subject.
Terms of sale
Over the counter.
Storage conditions
Trachisan drug should be stored in a maximum reach of children and teens a place at temperature not exceeding 25 ° C.
Shelf life
3 years.
Analogs
Grammidin
Bioparox
The main counterparts of the drug are Trachisan Td toxoid (Td-toxoid) and Derinat .
In some cases, to replace the tablet can Trachisan its analogs Likopid and Erbisol Ultrafarm .
Reviews Trahisane
The average score on the forums Trachisan tablets is 3, 8 5-point scale.
Advantages of this drug forum visitors find:
- the effectiveness of pain in the throat;
- taste;
- analgesic effect.
After analyzing the negative reviews online visitors identified the following weaknesses of the drug:
- high price;
- low efficiency.
Information about the preparation Trachisan Wikipedia there.
Price Trachisan where to buy
Trachisan average price in Ukraine is UAH 66.
The price of the tablet Trachisan in Moscow reaches 403 rubles.
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