Description overdue on 09/25/2014
- Latin name: Milgamma
- ATC code: A11DB
- Active substance: INN: Pyridoxine Thiamine + + + cyanocobalamin lidocaine (Pyridoxine + Thiamine + Cyanocobalamin + Lidocaine)
- Manufacturer: Worwag Pharma GmbH & Co. KG (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications Milgamma
- Contraindications
- Side effects
- Instructions for use Milgamma (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Composition Milgamma in the form of a solution for intramuscular injection contains several active agents. In particular, in the ampule contains: pyridoxine hydrochloride . thiamine hydrochloride . cyanocobalamin . Lidocaine hydrochloride .
Also the injections Milgamma contain additional substances: benzyl alcohol, potassium hexacyanoferrate, sodium hydroxide, sodium polyphosphate, water for injection.
Vitamin tablets contain in its composition benfotiamine . pyridoxine hydrochloride As well as their structure has colloidal silicon dioxide, anhydrous, sodium croscarmellose, microcrystalline cellulose, talc, povidone K30, long-chain partial glycerides.
Product form
The drug is available as a solution (Milgamma injections for intramuscular administration) as well as in the form of tablets or dragees.
Vitamins in form of a solution contained in a 2 ml ampoule. The vials are made of brown hydrolytic glass, each of them has a label and a white dot. The package - 5 or 10 vials.
Film-coated tablets are packed 30 or 60 pieces.
Also available dragees Milgamma Compositum - Biconcave, round shape, white. Drops contained in blisters of 15 pieces. The carton pack can be 2 or 4 blisters.
Pharmacological action
Wikipedia indicates that the drug Milgamma neurotrophic composition comprises vitamins, which belong to the group B. The drug is used in a therapeutic dose in diseases of nerves and nervous tissue, in which patients have violation nerve conduction inflammatory or degenerative conditions.
The drug Milgamma appointed as people with diseases of the musculoskeletal system. Use of the drug containing high doses of vitamin B, removes the sharp pain, stimulates microcirculation, improves blood formation and the functioning of the nervous system.
Vitamin B1 (thiamine), getting into the body, through phosphorylation turns into kokarboksilazu and thiamine triphosphate. In turn, cocarboxylase participates in the processes of carbohydrate metabolism, normalizing the function of the nervous tissue and nerves and improves conduction in nerves. If the body are deficient in vitamin B1, it can accumulate in the tissues of oxidized products of metabolism of carbohydrates, causing a variety of pathological conditions.
In determining what is best - Milgamma injections or tablets, it should be noted that the tablets instead of thiamine chloride in the composition has benfotiamine, a fat-soluble derivative of thiamine.
Vitamin B6 (pyridoxine), getting into the body, is phosphorylated. Its metabolism products involved in the decarboxylation of amino acids, resulting in the body produced physiologically active mediators - adrenaline , Histamine, tyramine, dopamine, Serotonin . In addition, vitamin B6 affects tryptophan metabolism.
Vitamins B1 and B6 provides a potentiation of the effect of each other, so vitamins Milgamma in injections and tablets have a marked beneficial effect on the health of patients with diseases of nerves and musculoskeletal system.
Cyanocobalamin (Cyanocobalamin) has antianemic impact, activates the synthesis of nucleic acids, choline, creatinine, methionine. He takes part in the metabolic processes in cells. The substance reduces pain, manifested as a result of disorders of the peripheral NS, activates the nucleic acid metabolism.
Lidocaine It has the effect of a local anesthetic.
Pharmacokinetics and pharmacodynamics
SUMMARY indicates that after intramuscular injection thiamin and is rapidly absorbed into the bloodstream. The body is unevenly distributed. Since substantial reserves of thiamine in the body is not present, he must do every day. The substance can penetrate the blood-brain and placental barriers. Excreted through the kidneys. Thiamine, compared with other vitamins is stored in the body in the smallest amounts.
Pyridoxine After the solution was intramuscularly administered quickly into the bloodstream and is distributed throughout the body. The plasma protein binds about 80% of the vitamin. The substance is able to cross the placenta, enters the breast milk. Later, it is oxidized to 4-pyridoxine acid which appears after 2-5 hours by the kidneys.
Cyanocobalamine Getting into the human blood binds to proteins, thereby forming a transport complex. Further in this form, it sucks hepatic tissue. It also accumulates in the bone marrow. After cyanocobalamin excreted in bile in the intestine, it can again be absorbed.
Indications Milgamma
The solution and tablets are appointed as part of an integrated treatment of diseases and syndromes of the nervous system that have different origins.
Defines the following indications for use Milgamma:
- optic neuritis;
- neuralgia ;
- optic neuritis;
- paresis the facial nerve;
- ganglionitis (including herpes zoster);
- neuropathy;
- plexopathy;
- alcoholic, diabetic polyneuropathy.
It is also testimony to the use of injections have people suffering from nocturnal seizures, neurological symptoms osteochondrosis spine. On what makes the drug in the complex therapy, and what shots Milgamma appointed even more detail can be obtained from your doctor.
Contraindications Milgamma to
Contraindications include:
- a high level of sensitivity to its components;
- decompensated heart failure.
Also contraindications for injection and tablets - a pregnancy Time Lactation children and age of the patient.
Side effects
Side effects Milgamma appear, usually in rare cases.
In particular, the following rare side effects:
- The immune system: allergic reactions .
- Nervous system: impaired consciousness, dizziness .
- Cardiovascular system: tachycardia . arrhythmia Aetiology.
- Digestive system: vomiting.
- Skin: heavy sweating, itch . acne .
- Musculoskeletal and connective tissue disorders: convulsions.
Sometimes, after the patient is administered Milgamma / in, it may occur irritation at the site where administered solution. The manifestation of systemic reactions can be observed only at very rapid introduction, or in the case of an overdose.
If manifested any other side effects or exacerbated by the negative effects described above, you should immediately tell a specialist that will give recommendations on how to prick ampules, or replace the drug.
Instructions for use Milgamma (method and dosage)
If the patients received injections Milgamma, instructions for use should be carefully observed them. Initially, the drug is administered deeply in a muscle in 2 ml once a day for 5-10 days. If injection intended for the maintenance treatment, then at 2 ml administered 2-3 times a week. Another option for maintenance therapy taking the drug in the form of tablets (1 tablet per day).
Instructions for use Milgamma indicates that rapid elimination of pain, use ampoules or tablets (1 tablet three times a day). Treatment can last for about one month. The health status of the patient's doctor should monitor weekly. Experts advise as soon as possible to move to the domestic drug. Note that candles Milgamma not released.
The course of treatment injections may last longer only on medical prescription. How often can chop shots and some form of release, preferably in each case, should also ask your doctor.
Overdose
If there is an overdose of drug, the patient can manifest those symptoms are described as side effects. In such cases, a symptomatic therapy.
Cooperation
If vitamin B1 is mixed with sulfate solution, it completely dissolves.
Inactivation of thiamine (benfotiamine) observed in the presence of acetate, mercury chloride, iodides, carbonates, riboflavin, tannic acid, ferric ammonium citrate, penicillin metabisulfite.
Pyridoxine at therapeutic doses may reduce the effect of levodopa, so with levodopa and drugs containing it, it does not apply. There is also interaction with penicillamine, cycloserine, isoniazid.
Cyanocobalamin is inactivated in the presence of heavy metal salts. Also a destructive influence on him has riboflavin, especially when parallel light.
Terms of sale
The pharmacy pills and Milgamma ampoules can be purchased by prescription.
Storage conditions
The tool should be protected from light, stored at a temperature not exceeding 15 ° C. Do not allow children access.
Shelf life
Shelf life 2 years.
Cautions
If the solution has been accidentally administered intravenously, the patient it is necessary to provide medical supervision and symptomatic treatment of adverse events.
No data on the effect on the ability to drive vehicles and operate the exact mechanism.
In veterinary practice, means may be used for dogs and other animals. However, it should be noted that such application is possible only after injections clear purpose veterinarian.
Analogs Milgamma
Neurobeks
Neurobeks Forte
Milgamma Compositum
Neyrorubin
If replacement is required for drugs could be considered to apply to treat similar drugs which have similar effects on the body. What can replace the tool detects a doctor, who will select the best analogues Milgamma in injections and tablets. You can pick up both imported and Russian counterpart. To date, the following drugs are known analogues Milgamma: Neyromultivit . Binavit, Triovite . Pikovit and others. The most optimal substitute - similar in composition analogue Combilipen And Neyromultivit. Price Milgamma counterparts, tend to be somewhat lower.
Is it better or Milgamma Combilipen?
The tool is also integrated Combilipen vitamin drugs, which includes B vitamins The drug is prescribed in complex therapy for patients with neurological diseases. It's similar means, but they have different manufacturers and Combilipen can be purchased at a lower price.
Neyromultivit or Milgamma: which is better?
The composition of these drugs is similar, but has no Neyromultivit among the components of lidocaine. Neyromultivit unlike Milgamma, prescribed for the treatment of children. Why is assigned to each of the drugs in more detail to explain the treating specialist.
Babies
The drug is assigned only to adolescents from 16 years of age.
With alcohol
Milgamma prescribed after alcoholic intoxications to restore the body. At the same time alcohol and Milgamma in injections and tablets, is used should not be. Despite the fact that the compatibility of the drug with alcohol in the official instructions not described in this combination completely neutralize the positive effect of the drug. Also, a number of side effects can cause the combination of alcohol and lidocaine: it headache . drowsiness . state of anxiety .
During pregnancy and lactation
With pregnancy As well as during breast Milgamma women is not appointed, as there is insufficient information on the impact of its components to the fetus during pregnancy and during breast-feeding .
Reviews milgamma
There are numerous reviews of milgamma who left as patients receiving such treatment and specialists. The review noted that intramuscular injections are quite painful, sometimes marked irritation at the site, which was administered an injection. But more often described a positive effect in the treatment of neuralgia, neuritis and other diseases that occurred after the patient was administered injections Milgamma. Reviews of doctors contain information that during treatment, patients should maintain a correct way of life and to carry out all the recommendations, as the only means of eliminating the symptoms but not the cause of ailments.
It is often noted as the effectiveness of drugs in the treatment, which is prescribed not only the drug, and other medicines. For example, a good effect can be obtained if appointed Movalis and Milgamma simultaneously. Movalis - nonsteroidal anti-inflammatory drug, has a pronounced positive effect in diseases of the musculoskeletal system.
Price Milgamma where to buy
Price Milgamma shots №5 averages 270 rubles. Price Milgamma injections in ampoules №10 is from 430 to 500 rubles. Price injections Milgamma (package of 25 pcs.) On average 1000 rubles. Buy Milgamma in Moscow (tablets, 30 pcs.) Can be an average of 600 rubles.
Cost ampoules in Ukraine - from 80 to 110 hryvnia per pack 5 pcs. How much is the medication in different packages, you should learn a particular point of sale. The drug in tablets (30 pcs.) You can buy an average of 180-200 hryvnia.
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