Ksarelto

Description overdue on 06/18/2014

• Latin name: Xarelto
• ATC code: B01AF01
• Active substance: Rivaroxaban (Rivaroxaban)
• Manufacturer: Bayer Pharma AG., Germany

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications for use drugs Ksarelto
• Contraindications
• Side effects
• Instructions on Ksarelto (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

Tablet contains:   Rivaroxaban micronized in an amount of 10, 15 or 20 mg, and auxiliary components: microcrystalline cellulose, croscarmellose sodium, hypromellose 5cP, lactose monohydrate, magnesium stearate, sodium lauryl sulfate and.

Film coated tablets consist of: iron oxide red dye, Valium 15cP . Titanium dioxide   and macrogol 3350.

Product form

Ksarelto available in tablets, film-coated with different contents of active substance. They have a round biconvex shape, pink-brown or reddish color, double-sided engraving - on one hand - and the triangle symbol dosage, on the other dealt a brand Bayer cross. Sales package offered from 5 to 100 pieces.

Pharmacological action

Inhibiting preparation Factor Xa , An anticoagulant of direct action .

Pharmacodynamics and pharmacokinetics

For active substances of the drug -   Rivaroxaban , Characterized by a rapid impact, predictable dose response and high bioavailability. It does not require monitoring of coagulation parameters, there is practically no risk of incompatibility with other foods or medicines.

The drug is used as a prophylactic against stroke   in patients suffering Atrial Fibrillation , Displaying a good efficacy and tolerability. This anticoagulant can be administered once a day, following a fixed dose.

Rivaroxaban   It has a high absolute bioavailability is 80-100%. The main component is rapidly absorbed with the onset of the maximum concentration after 2-4 hours. Once in the body, there is a significant relationship with the main part of the rivaroxaban plasma proteins, namely, plasma albumin . Withdrawal is carried out mainly in the form metabolites .

Indications for use drugs Ksarelto

The main indications are:

• prevention   venous thromboembolism After large-scale orthopedic surgery of the lower limb;
• prevention stroke   and systemic thromboembolism   at non-valvular atrial fibrillation origin   and so on.

Contraindications

• active bleeding, especially affecting vital organs such as the gastrointestinal tract, and other intracranial region;
• liver disease accompanied coagulopathy Causing the risk of bleeding;
• lactation, pregnancy;
• age of patients less than 18 years;
• congenital lactase deficiency or intolerance, galactose malabsorption glucose;
• high sensitivity to rivaroxaban and other excipients.

Side effects

Treatment Ksarelto (Xarelto) can cause a variety of adverse events affecting virtually all organs and systems. It is often they occur moderately.

The most common side effects include:

• anemia;
• nausea . transaminases . increased activity of GGT ;
• hemorrhage   after treatments, including post-operative anemia   and bleeding from wounds.

Less frequently occur:

• thrombocythemia, increased platelet count;
• tachycardia, hypotension;
• constipation, diarrhea, pain and abdominal discomfort, dyspepsia, dry mouth;
• dizziness, headache, short-term loss of consciousness;
• bleeding from the gastrointestinal tract, nose, hematuria, bleeding from the genital tract;
• Local edema, general health deterioration, fever, allergic reactions   and so on.

Instructions on Ksarelto (method and dosage)

According to the instructions for use Ksarelto, during the prevention of VTE after major orthopedic surgery, the patient is prescribed a daily reception of 10 mg of the drug. The duration of treatment is 2-5 weeks, depending on the scale and complexity of the intervention.

This drug may be taken at any time, regardless of food intake. Xarelto is necessary to begin treatment after 6-10 hours after surgery if reach hemostasis .   When you miss a dose you should immediately take medication Ksarelto, and the next day you need to continue treatment as usual.

Overdose

In case of overdose rivaroxaban   usually develop hemorrhagic complications associated with pharmacodynamic characteristics of the drug. Currently specific antidote Rivaroxaban   It has not been developed.

To reduce suction Rivaroxaban   Recommend for 8 hours to accept Activated carbon.

Cooperation

Simultaneous use of the strongest Ksarelto   inhibitors of CYP3A4 and P-gp can cause a decrease in hepatic and renal clearance, resulting in a significant increase in systemic exposure and pharmacodynamic drug action.

Determined that Clarithromycin, erythromycin   and Fluconazole   may result in different changes in the concentration of Rivaroxaban But it is considered a normal variation procedure and clinically insignificant.

It should refrain from joint application Rivaroxaban   and dronedarone As clinical data about such a combination no.

Admission and Ksarelto rifampicin Which refers to the strong inducers of CYP3A4   and P-gp It leads to a lowering of the pharmacodynamic effects of the drug. Therefore, treatment with this drug with other strong inducers should be done with caution.

Terms of sale

Medicine sell only on prescription.

Storage conditions

Tablets should be stored in a location protected from children at less than 30 ° C.

Shelf life

If you comply with the conditions of storage, the drug can be used for 3 years.

Analogs of the drug Ksarelto

As is known, analogs Ksarelto represented only by its active substance or Rivaroxaban INN - anticoagulant of direct action . Therefore, it is considered its main substitute. The price of the analogue package at 14 pieces of 1956-2000 rubles.

Ksarelto or Pradaksa   - what's better?

This question is asked by many patients who are concerned about a possible thrombus formation. As shown by recent studies, and Ksarelto Pradaksa   have practically the same efficiency in preventing blood clots   and Risk bleeding   at atrial fibrillation . Acceptance of each of these drugs does not require constant monitoring of INR. Thus the cost of these drugs is quite high, compared to other anticoagulants.

Alcohol and Ksarelto

Clinical studies have shown that treatment with this drug is categorically not compatible with alcohol, as this may lead to undesirable consequences.

Reviews Ksarelto

In general reviews about Ksarelto include discussion of the risks of active or latent bleeding affecting any tissues or organs, which often leads to anemia hemorrhagic nature.   At the same time reviews of Ksarelto patients who took the drug, contain information about the frequent hemorrhagic complications in the form of: weakness, dizziness, paleness, shortness of breath, swelling   and so on.

Also, feedback on the forums are a vibrant debate over the high cost that is affordable for all patients.

Price Ksarelto where to buy

This medicine is available in tablets, coated tablets, with different contents of active substance. Buy Ksarelto in Moscow at any pharmacy on prescription. The price Ksarelto 10 mg of 10 pieces in the package is from 1226 rubles, the cost xarelto 20 mg 14 pieces - from 1564 rubles, and 15 mg of the drug for 28 pieces ranging from 2857 to 3020 rubles.

If you want to buy in St. Petersburg these tablets, it should be noted that the price Ksarelto 20 mg significantly higher than at the drug dosage. Pharmacies in Kiev offer the medicine for as low as 188 USD.

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