Vigantol

Description overdue on 09/11/2014

• Latin name: Vigantol
• ATC code: A11CC05
• Active substance: Kolekaltsiferol (Colecalciferol)
• Manufacturer: Merck KGaA, Germany

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Vagintol (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

The composition includes a surfactant Vigantola:   Kolekaltsiferol.

An additional component is triglycerides .

Product form

Available Vigantol as an oil solution for oral administration, is placed in the dropper bottle of dark glass.

Pharmacological action

The drug has a regulating calcium-phosphorus metabolism pharmacological action.

Pharmacodynamics and pharmacokinetics

The purpose of this is to regulate drug metabolism   Calcium   and Phosphorus . At the same time fill the shortage Vitamin D3 , Enhanced calcium absorption in the gastrointestinal tract and phosphate reabsorption in the kidney. Vigantol also promotes bone mineralization, it is necessary to complete the work of the parathyroid glands.

The absorption of the drug from the gastrointestinal tract occurs. Inside the organism active agent binds to α2-globulin, with some of the albumin .

Accumulation kolekaltsiferola   in the liver, bone and adipose tissue, skeletal muscle, kidney and adrenals, myocardium. Achieving the maximum concentration of a substance in the tissue is noted after 4-5 hours, then lowered a bit, but still a long time saved at the required level.

Determined that Kolekaltsiferol   It penetrates the placental barrier and is released in the composition of breast milk.

As a result of biotransformation in the liver and kidneys are formed inactive metabolites   - kaltsifediol   and digidroksikolekaltsiferol , The active metabolite calcitriol .

Deducing is happening advantage of with bile and a small part with urine.

Indications

The main indications for use Vigantola are:

• rickets;
• spazmofiliya;
• osteomalacia.

Contraindications

Not recommended take the drug when:

• hypersensitivity;
• hypercalcemia;
• hypercalciuria;
• the presence of calcareous stones in the kidney;
• sarcoidosis;
• immobilization.

Side effects

Sometimes it may develop undesirable effects:

• hypercalcemia;
• hypercalciuria;
• arrhythmias;
• nausea;
• vomiting;
• disturbances of consciousness and mind;
• underweight;
• urolithiasis;
• calcium deposits in soft tissue structure;
• loss of appetite, thirst and polyuria.

Instructions on Vagintol (method and dosage)

In the instruction to the drug explains in detail, how to accept Vigantol for newborns. To do this you need to mix in a spoonful of medicine with milk or other liquid.

When prevention rickets   healthy and full-term babies from 2 months of daily administered 1 drop per day. Take the medicine for 5 days. Then make a two-day break. Children 1-2 years is not recommended to take the drug in the summer months. For premature babies with 10 days of life prescribed daily dosage of 2 drops for 5 days, performing two-day break, the summer months are the exception.

During treatment of rickets Vigantol instruction on the application recommends the higher dosages. For example, children from 10 days of life can be taken daily for 2-8 drops.

In other cases, the dose and duration of therapy is determined by a specialist. Pre-installed component failure Vitamin DZ The level of which must be controlled, and in the course of treatment.

Overdose

Typically, overdosing due to the fact that the child's body accumulates excess   Vitamin DZ . At the same time the symptoms of hypervitaminosis D3 include: constipation   or diarrhea, headache, pollakiuria , Thirst, nocturia, anorexia, polyuria , Metal taste in the mouth, weakness, nausea, vomiting and so on. It is also possible the development of more complex disorders: bone pain, clouding of urine, increased blood pressure, itching , Conjunctival hyperemia, mialgia, arrhythmia   and another.

Patients developing prescribe hypercalcemia Which depends on its severity. It is therefore possible: removal of the drug, the introduction of low-calcium diet, the consumption of high-volume liquid appointed vitamin E, ascorbic acid, retinol, thiamine, pantothenic acid .   riboflavin . Severe cases require the in / in a solution sodium chloride 0, 9%, furosemide, calcitonin, electrolytes , Hemodialysis. To exclude an overdose, it is necessary to regularly monitor the concentration of calcium in the blood.

Cooperation

Application of phenytoin, primidona   and drugs of barbiturates increases the rate of biotransformation improver need vitamin D3.

Simultaneous use for a long time antacids , In which are contained aluminum particles and magnesium, may enlarge their concentration in composition blood, and also persists risk Development intoxication.

The combination and Vigantola calcitonin, bisphosphonates   and plicamycin   reduce the efficiency of the drug. And Kolestiramin colestipol   reduce the gastrointestinal absorption of some fat-soluble vitamins, which requires increasing their dosage.

Combined treatment of cardiac glycosides increase the toxic potential because hypercalcemia . Such patients is required control of level of calcium, ECG, adjustments dose of cardiac glycosides. Also, risk of development of hypercalcemia   can increase derivatives benzodiazepine.

Allowed to combine Vitamin D3 , Its analogues or metabolites, but only in special cases strict control of calcium in blood serum composition.

It is known that thiazide diuretics   inhibit the process of excretion of calcium in urine composition that contributes to the development of hypercalcemia. Thus it is necessary to carry out regular monitoring of blood calcium.

Lowering the effectiveness of this drug observed while treating rifampicin   and isoniazid Since they increase the rate of biotransformation.

Terms of sale

Vigantol prescription.

Storage conditions

For storage of the drug is designed dark, sheltered place away from children at a temperature of 15-25 ° C.

Shelf life

5 years.

Analogs

The main counterparts of the drug are: Akvadetrim, Videhol, vitamin D, Kolekaltsiferol, cholecalciferol   and so on.

Is it better or Akvadetrim Vigantol?

Young patients from the very birth of prescribed drugs that increase the content vitamin D . Pediatricians often offer or choose Vigantol Akvadetrim . Therefore, parents are wondering which of these drugs is better? Experts in the field of Pediatrics advised parents to specify what kind of medication you need to take their child, since in some cases it may be more useful oily solution, while others - water.

Alcohol

The data about the interaction of Vigantola and of alcohol is not contributed by.

Reviews Vigantole

On health care and children's forums found a lot of reviews about the drugs that are prescribed for a lack of   Vitamin D3 . Parents share their experiences on various means, wonder what medicine give other kids.

According to many users, pediatricians prescribe them kiddies aqueous solution Akvadetrim.   At the same time, in some cases, the orthopedic examination, these children are diagnosed rachitic changes. After that, prescribers in oil solutions, for example, or Vigantol Vitamin B2 ergocalciferol.

As the reviews of Vigantole for newborn children is often prescribed this drug. As a result of 1-2 years they do not reveal any pathological changes in bone structure. Also, despite the a high probability of of development of side effects, descriptions undesired reactions on the background of Reception Vigantola in a network are not represented.

Price Vigantola where to buy

Buy in Moscow the drug can be at cost 190-220 rubles. In regions Vigantola price ranges 180-200 rubles.

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