Manin

Description overdue on 27.10.2011

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The main active ingredient is the current glibenclamide . Manin - hypoglycemic drug belongs to the group of second-generation sulfonylureas. It has pancreatic and extrapancreatic mechanisms of action. Glibenclamide stimulates insulin   and increases the effect insulinovydelitelnoe Glucose . Under the influence of the drug increases the sensitivity of pancreatic cells to glucose-dependent insulinotropic polypeptide. Extrapancreatic effect is achieved by increasing the sensitivity of insulin receptors. Manin in therapeutic doses, reduces the risk of complications such as nephropathy, retinopathy, cardiomyopathy, reduces mortality from diabetes. The drug has antiarrhythmic   and cardioprotective   action that allows you to assign it to diabetics with concomitant coronary heart disease. Glibenclamide reduces platelet aggregation, prevents vascular complications of diabetes. The drug works more than 12 hours. The micronized form glibenclamide is rapidly absorbed from the gastrointestinal tract, allowing the drug to be more physiological and gently.

Indications:

Maninah appoint at an inefficiency of of dietotherapy in DM 2-th type. It is used in combination therapy with insulin in the daylight control glucose levels.

Contraindications:

The first type of diabetes, diabetic precoma . coma . ketoacidosis . hyperosmolar coma , Extensive burns, trauma, radiation, infectious diseases, pregnancy, microangiopathy, hepatic, renal failure, bowel obstruction. Be wary appointed to adrenal insufficiency, alcoholism, fever syndrome, diseases of the thyroid gland.

Side effect:

With inadequate diet violations Manin dosing regimen may lead to hypoglycemia . It is also noted fever, weight gain, allergies, arthralgia, dyspepsia, proteinuria, neurological disorders, cholestasia , Disorders of the liver, disorders of the blood, late cutaneous   porphyria , Polyuria, headache, photosensitivity, a violation of taste perception, headaches, fatigue.

Mode of application:

Manin Dose picked individually, taking into account the severity of the disease, the patient's age, blood sugar levels. The average daily dose of 2 mg 5-15. Glibenclamide take three times a day for half an hour before meals.

Overdose:

Increased sweating, hunger, speech, mind, view, tremor , Palpitations, irritability, insomnia, depression , Brain swelling and other symptoms hypoglycemia , Coma. Treatment: Take sugar inside. If the patient is unconscious, then enter dextrose intravenous bolus, glucagon, diazoxide. Every 15 min. carry out the control of blood glucose levels. To prevent re hypoglycemia should give the patient foods rich in carbohydrates (digestible). If swelling of the brain appointed dexamethasone Mannitol.

Special instructions:

Requires regular monitoring of blood sugar levels, monitor the daily curve of glucose concentration. At simultaneous reception of ethanol can be celebrated a pronounced gipoglikemiceski effect, headache, diarrhoeic disorder. During the period of treatment is not recommended for a long stay in the sun. When you change the diet, emotional and physical overexertion require dose adjustment Manin. Reduces the rate of reaction when driving.

Drug Interactions:

Antifungal drugs, ACE inhibitors, NSAIDs, fibrates, TB drugs, anticoagulants   coumarin, salicylates , Beta-blockers, anabolic steroids, MAO inhibitors, biguanides, fenfluramine, tetracycline , Chloramphenicol, pentoxifylline Cyclophosphamide, acarbose, pyridoxine, disopyramide, bromocriptine, reserpine, allopurinol . insulin   enhance the effect of Manin.

Agonists, barbiturates, antiepileptic drugs, carbonic anhydrase inhibitors, BCCI, chlorthalidone, thiazide diuretics, Furosemide . baclofen , Glucagon, terbutaline, asparaginase, danazol, isoniazid , Ritodrine, morphine, salbutamol , Diazoxide, danazol, ritodrine, glucagon, thyroid hormones, rifampicin, chlorpromazine, nicotinic acid, lithium salts, estrogens, oral contraceptives weaken effective action Manin. Large doses ascorbic acid , Ammonium chloride reabsorption increase drug enhancing the effect of glibenclamide. In simultaneous reception with drugs, oppressive bone marrow hemopoiesis, is celebrated increase in the risk mielosupression .