Dikloberl

Description overdue on 04.11.2011

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Main, an active substance - diclofenac . Dikloberl belongs to the group of NSAIDs. It has a pronounced anti-inflammatory effects by inhibiting the synthesis prostaglandins . Diclofenac reduces swelling of tissues in inflammation, has analgesic, antipyretic effect. Drug decreases platelet adhesiveness by the action of ADP and collagen. In intramuscular Dikloberla maximum concentration of the basic substance is observed after 20 minutes. When taken orally Dikloberl completely absorbed from the intestine, and the maximum concentration recorded over 2 hours. With the introduction of the suppository Cmax observed after half an hour.

Indications:

Dikloberl prescribed for degenerative, inflammatory diseases of ODA: psoriatic, rheumatoid , Juvenile arthritis   (chronic form), neuralgic amyotrophy , Ankylosing spondylitis . rheumatism , Osteoarthritis, gouty arthritis, when Reiter's disease . Dikloberl relieves pain: bursitis . migraine , Lumbago, toothache, tendinitis . ossalgia , Sciatica, myalgia, radiculitis . neuralgia , Cancer, post-traumatic, post-operative pain. Adnexitis , Tuberculosis, infectious diseases, upper respiratory tract, otitis . pharyngitis . tonsillitis .

Contraindications:

"Aspirin" triad, "Aspirin" asthma, disorders of the blood, ulcerative lesions of the gastrointestinal tract, blood clotting disorders, pregnancy. Suppositories are not prescribed for hemorrhoids , Rectal bleeding, inflammation, trauma rectum and anus. With caution is prescribed for Diklober asthma . anemia , Hypertension, decompensated heart failure, edema syndrome diverticulitis , Liver failure, diabetes-induced acute porphyria, renal failure, elderly patients.

Side effect:

Gastrointestinal tract : Cramps, abdominal pain, diarrhea, abdominal distention , Dyspepsia, increased liver enzymes, peptic ulcers, gastrointestinal bleeding, melena, jaundice, vomiting, thrush , Gepatonekroz,   hepatitis , Pancreatitis, hepatorenal syndrome, colitis Cirrhosis. Nervous system Irritability, headaches, sleep disturbances, diplopia, aseptic meningitis , Anxiety, dizziness, weakness, cramps, depression . Senses : Tinnitus, scotoma, hearing loss, taste perversion, nechekost visual perception. Skin : alopecia , Itching, eczema , Erythema multiforme, toxic dermatitis, urticaria, rash, photosensitivity, toxic epidermal necrolysis. Genito-urinary system : Fluid retention, oliguria, proteinuria, nephrotic syndrome , Interstitial nephritis, azotemia, acute renal failure, papillary necrosis . Forming Organs Anemia, eosinophilia, thrombocytopenia, leukopenia, thrombocytopenic purpura, agranulocytosis. Respiratory system Cough, laryngeal edema, bronchospasm. Allergies: swelling of the tongue, lips, rapid anaphylactic shock .

Mode of application:

Dikloberl taken during or after meals three times a day, 25-50 mg. After achieving the desired therapeutic effect, reduce dosage. The day not more than 150 mg. Dikloberl depot administered in a dose of 100 mg once a day. Dikloberla solution prior to administration diluted in NaCl, administered intravenously (30-180 minutes). Rectal: twice a day 50 mg or 100 mg once

Overdose:

Hyperventilation , Vertigo, dizziness, dyspepsia, bleeding, convulsions , Epigastric pain, disruption of the renal and hepatic systems. Hemodialysis and forced diuresis   ineffective.

Special instructions:

If you want to achieve a rapid effect Dikloberl take half an hour before a meal. It is necessary to be vigilant when administering the drug to patients taking diuretics, renal failure, heart failure with reduced BCC. When long-term therapy required monitoring of the hepatic system, blood picture, analysis of stool for occult blood. The drug reduces the rate of reaction.

Drug Interactions:

Dikloberl increases the concentration of: drugs Li, Methotrexate . cyclosporine . digosksina . It decreases the effect of hypnotics, hypoglycemic, hypotensive, diuretic drugs. Diclofenac increases the toxicity of methotrexate and cyclosporine. At the same time taking ASA sniaetsya drug levels in the blood. Paracetamol, drugs Au increase nephrotoxicity Dikloberla. Tsefotetan, ceftazidime, valproic acid, cefamandole, plicamycin lead to gipoprotrombinemii . Colchicine Ethanol, corticotropin, St. John's wort preparations cause gastrointestinal bleeding.