Description overdue on 06/11/2014
- Latin name: Concor Cor
- ATC code: C07AB07
- Active substance: Bisoprolol (Bisoprolol)
- Manufacturer: MERCK, KGaA (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Concor Cor
- Contraindications
- Side effects
- Instructions for use Concor Cor (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Compatible Losap and Concor Cor
- Price, where to buy
Composition
The composition of one tablet Concor Cor includes hemifumarate and bisoprolol fumarate in a proportion of 2: 1.
Excipients: colloidal silica , corn starch, MCC, crospovidone, magnesium stearate, calcium hydrogenphosphate.
The composition of the shell: macrogol 400, hypromellose, dimethicone 100, titania.
Product form
Concor Cor - tablets covered with a white cover, lenticular, heart-shaped, with a notch at both ends.
The existing forms of release: 10 tablets in a blister, 3 blisters in a pack of paper; 14 or 30 tablets in a blister, 1 blister pack in the paper; 25 tablets in a blister, 1 blister pack in the paper.
Pharmacological action
Renders hypotensive, antiarrhythmic, antianginal action.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Bisoprolol - Selective Beta-blockers Without having sympathomimetic activity and membrane stabilizing action.
Decreases: contents of renin in the blood, the heart's need for oxygen, the heart rate. Blocks in small doses β1-adrenergic receptors It reduces activation catecholamines synthesis cAMP from ATP , Lowers intracellular calcium ion transit, oppressing conductivity and anxiety, inhibits the AV-conduction. At higher doses of β2-adrenergic blocking has effect.
Total peripheral resistance in the first few hours increases, and after 1-3 days comes to the original value, and in long-term assignment is reduced.
The pressure drop caused by sympathetic action on peripheral blood vessels, reduction in blood minute volume braking operation renin-angiotensin system. At hypertension effect appears after 2-5 days.
Antianginalnoe effects caused by a decrease in the heart's demand for oxygen by reducing the number of heartbeats per unit time and contractility, lengthening diastole .
Antiarrhythmic effect associated with the removal of tachycardia . hypertension , Increased activity sympathetic , Increased content cAMP , Braking AV-conduction .
Pharmacokinetics
Bioavailability - 85-90%; meal is not affected. Bisoprolol It is absorbed from the intestine by 90%. Maximum concentration in the blood occurs within 3 h. Linking blood protein - 35%.
Undergoes oxidative transformation of the way. Basic derivatives pharmacologically inactive. Excreted by the kidneys.
Indications Concor Cor
Indications for use of the drug is limited. Persons over age group often suffer Heart Failure Chronic type, from which tablets Concor Cor is prescribed for treatment of this disease.
Contraindications
- Hypersensitivity to bisoprolol or other components of the drug.
- AV-block .
- Acute and chronic (decompensation) heart failure .
- Arterial Hypertension .
- Sick sinus syndrome .
- Bradycardia .
- Sinoatrial block .
- Bronchial asthma or COPD .
- Cardiogenic shock .
- Disturbances in blood level of the peripheral circulation.
- Pheochromocytoma .
- Age 18 years.
- Metabolic acidosis .
Side effects
- General disorders: asthenia , Fatigue.
- From the nervous system: syncope . dizziness .
- Mental disorders: depression , Hallucinations, insomnia .
- From the senses of vision: conjunctivitis , Hearing impairment.
- From the circulatory system: reduced pressure violation AV-conduction , Slowing heart rate, orthostatic hypotension .
- From the respiratory system: bronchospasm . nasal allergy .
- From the muscular system: convulsions .
- From the digestive system: vomiting . nausea . diarrhea . hepatitis .
- Reproductive system: the deterioration potency .
- Skin: itching, rash, redness, alopecia .
- Laboratory indicators: increase in content triglycerides, AST and ALT
.
Instructions for use Concor Cor (method and dosage)
Instruction in medicine recommends taking pills in the morning, orally with water. Do not chew, grind.
Treatment of chronic heart failure means such as Concor Cor requires titration and constant medical supervision. In the titration of the dose can be increased only after the previous dose tolerated satisfactorily.
The maximum dose for the treatment of chronic heart failure type - bisoprolol in an amount of 10 mg once a day.
At the beginning of the treatment while taking half a tablet Concor Cor patient should observe the first 4 hours, by monitoring heart rate, pressure, conductivity performance.
Overdose
Symptoms: bronchospasm, AV-block, bradycardia, hypoglycemia, excessive pressure drop, acute heart failure.
Treatment of overdose: drug discontinuation and symptomatic treatment.
Cooperation
Iodine radiopaque agents and allergens for immunotherapy increases the risk of systemic allergic reactions in patients receiving bisoprolol .
Phenytoin , Means for inhalation anesthesia increases cardiodepressive and hypotensive action bisoprolol .
Nonsteroidal anti-inflammatory agents . glucocorticosteroids and Estrogens inhibit hypotensive the effect of the drug Concor Cor.
Cardiac glycosides, guanfacine, verapamil, reserpine, methyldopa, diltiazem and antiarrhythmics increase the risk of AV-blockade, bradycardia and heart failure.
Nifedipine, diuretics, sympatholytic, clonidine, hydralazine lead to a strong reduction in the pressure.
Tetracyclic and tricyclic antidepressants, antipsychotics, ethanol, sedatives can enhance the oppression of the nervous system.
Ergotamine increases the risk of disturbances of peripheral blood flow.
Terms of sale
To purchase the drug requires a prescription.
Storage conditions
- At temperatures below 25 ° C.
- Keep away from children.
Shelf life
Three years.
Cautions
The drug does not alter the ability to drive.
Analogs Concor Cor
Nebivolol
Biprol
Bisoprol
Lokren
Concor
Niperten
Betaloc ZOK
Betalok
Coronal
Egilok
Nebilet
Atenolol
Metoprolol
The most common analogs Concor Cor: Bikard, Krka bisoprolol, bisoprolol-Richter, Bisoprofar, Dorez, Concor, Coronal and others.
Alcohol and Concor Cor
Concor Cor and alcohol - not recommended combination, since there is a strengthening of the negative effects of ethanol.
During pregnancy (and lactation)
During Lactation or pregnancy the drug can be used with great caution, taking into account all the risks carefully.
Reviews of Concor Cor
Reviews doctors Concor Cor medorientirovannye forums and appreciate the therapeutic effects of the drug, including the delayed period of time.
Compatible Losap and Concor Cor
Frequently asked question. These drugs are generally well tolerated and completely compatible. When used Concor Cor sometimes recommended for morning Losap evening.
Price Concor Cor where to buy
Price package Concor Cor №30 in Russia is 155-190 rubles, Ukraine, the average price - 54 hryvnia.
No comments:
Post a Comment