Description overdue on 10/17/2014
- Latin name: Zhenale
- ATC code: G03XB01
- Active substance: Mifepristone (Mifepristone)
- Manufacturer: Izvarino Pharma Ltd., Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Zhenale (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
One tablet contains: active substance mifepristone - 10 mg plus additional ingredients ( potato starch, carboxymethylstarch sodium, lactose monohydrate, povidone, magnesium stearate ).
Product form
The drug release in the form of circular, convex tablets. Color - yellow with green. The containers or cans on a single tablet, in unit 1 or 2 tablets.
Pharmacological action
Contraceptive . antigestagens .
Pharmacodynamics and pharmacokinetics
The active ingredient of the drug - mifepristone - steroid synthetic tool that significantly reduces sensitivity progestin receptors . The substance does not have a progestin activity It is antagonist of glucocorticoids on competitive mechanisms.
Effect of the drug depends on the phase of the menstrual cycle, during which he entered the body. The tool increases contractility myometrium and stimulates output IL-8 at horiodetsidualnyh cells, wherein the degree of sensitivity of the myometrium to prostaglandins greatly reduced.
As a result, ovum derived from decidua . ovulation not happening, endometrium It becomes thin and weak. And if there is already a fertilized egg its implantation becomes impossible.
When administered orally at 1, 5:00 reaches its maximum drug concentration in blood, bioavailability - about 70%. Almost 99% of the active ingredient binds to proteins in the plasma.
Excretion of the drug is carried out in two phases, first slowly and then 12-72 hours faster. The half-life - 17 hours.
Indications
The tool is used as a Emergency Contraception after already having sexual intercourse (unsuccessful termination, the condom broke, the error in the calendar method, spolzshey condoms, etc.). The maximum effective period of time when the drug exactly podeystvuet- 72 hours.
Contraindications
The pill should not be used:
- if carried out before long-term treatment GSK ;
- at porphyria ;
- for liver or kidney problems;
- at anemia ;
- gipotrofirovannoy function adrenal ;
- at pregnancy ;
- during breast-feeding ;
- allergies on the components of the drug;
- in violation homeostasis organism;
- in severe extragenital pathology.
Side effects
The most common side effects are:
- pain and discomfort in the abdomen, bleeding, worsening of chronic inflammatory processes;
- dizziness and headache ;
- allergy Weakness, hives ;
- hyperthermia , Nausea and diarrhea.
Instructions on Zhenale (method and dosage)
The drug is taken orally, 2 hours after a meal or 2 to.
Before taking you should consult with your doctor.
According to the instructions for use of the pill must be taken within 72 hours after NLA .
Overdose
In case of overdose can occur adrenal insufficiency .
Cooperation
Within 8-12 days after the pills are not recommended NSAIDs .
Alcohol greatly reduces the effectiveness of funds.
Terms of sale
To purchase medicines in pharmacies need a prescription.
Storage conditions
Store in a dry, cool place.
Shelf life
3 years.
Cautions
Zhenale - means of emergency contraception, it is impossible to use several menstrual cycles in a row. In subsequent sexual acts that take place within a month after admission, definitely use barrier methods of protection.
The drug does not protect against a variety of STD and AIDS .
There Zhenale tablets containing 50 or 200 ml of the active substance (for medical abortion ), They can be used only under medical supervision. employee and strict doctor's advice.
The drug has no effect on the reaction rate and concentration.
Dosage 10 g is not capable of causing abortion . In connection with this pre agents should ensure that no pregnancy. If the use of the drug after the pregnancy, it is better to abort any recommended by your doctor. In the event that woman decided to leave the child, there is no guarantee that he will be born and grow up healthy.
Efficacy depends on body weight, while overweight efficiency is reduced.
Analogs
Esmiya
Mifegin
Miropriston
Ginepriston
Mifepristone
Penkrofton
Common analogues Zhenale: Ginepriston, Agesta, Mensofta, Mifegin, Mifepreks, Mifolian, eskapel, Postinor, Gynestril administration, Miropriston, Mifepristone, Penkrofton .
Zhenale or eskapel - which is better?
Eskapel relates to preparations containing progestogens (hormones). Means, unlike the original, effectively only the first 24-48 hours after NLA . Also, when receiving analog increases the likelihood ectopic pregnancy . The cost of drugs is about the same.
Postinor or Zhenale - what to choose?
Postinor also contains progestogens . Efficiency means is highly dependent on the patient's body weight (from the original, the figure below). After receiving analog greater the likelihood of unwanted side effects - bleeding, general ill health, delay the next menstruation. Both products are in the same price category.
Reviews Zhenale
Zhenale - reviews of doctors
Experts believe that the drug is more effective than its predecessors, containing progestogens . Gynaecologists Reviews of Zhenale positive, it is not a hormonal drug. Experts say high performance, regardless of the time elapsed since the NLA (not later than 72 hours). But mifepristone often causes a delay in menstruation.
Reviews Women . taking pills, good. Many people write that are not observed nausea, pain and bleeding as when taking other medications. However, there were some minor irregularities in the menstrual cycle. One of the women after taking the drug still pregnant, but she could not bear a child. If it is not the use of this emergency contraception doctors recommend unwanted pregnancy.
Price Zhenale
Price Zhenale the pharmacy - about 300 rubles per pack.
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