Description overdue on 01/09/2014
- Latin name: Pylobact AM
- ATC code: A02BD05
- Active substance: Amoxicillin (Amoxicillin), omeprazole (Omeprazole), Clarithromycin (Clarithromycin)
- Manufacturer: Ranbaxy (India)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Reviews
- Price, where to buy
Composition
The active substance Omeprazole It is about meprazol . In addition, the drug contains the following additional components: pellets of saccharose and corn starch, povidone, sodium lauryl sulfate, lactose, mannitol, purified talc, sodium hydrogenphosphate.
The capsule shell consists of the following components: a brilliant blue, gelatin, propilpargidroksibenzoat, karmoizin, methyl parahydroxybenzoate. The composition of enteric coating include diethyl phthalate, hypromellose phthalate, isopropanol, titanium dioxide, dichloromethane.
Pills Clarithromycin It contains as active substance Clarithromycin And furthermore the following additional components: colloidal silicon dioxide, stearic acid, croscarmellose sodium, talc purified, magnesium stearate, MCC povidone.
The film coating consists of hypromellose, propylene glycol, titanium dioxide, vanillin giproloza, sorbitan monooleate, quinoline yellow dye, purified talc.
Capsules Amoxicillin They have the active ingredient is Amoxicillin trihydrate . Furthermore, they include the following additional ingredients: microcrystalline cellulose, croscarmellose, magnesium stearate, colloidal silicon dioxide, sodium lauryl sulfate.
The body of the capsule includes quinoline yellow dye, titanium dioxide, coloring agent sunset yellow, Propyl, gelatin, methyl parahydroxybenzoate, sodium lauryl sulfate. A cap has such components as coloring quinoline yellow, methyl parahydroxybenzoate, brilliant blue dye, propyl parahydroxybenzoate, sodium lauryl sulfate, azorubin dye, titanium dioxide, gelatin.
Product form
Package includes AM Pilobakt Omeprazole and Amoxicillin capsules, as well as Clarithromycin tablets.
Pharmacological action
The drug belongs to the anti-ulcer agents.
Pharmacodynamics and pharmacokinetics
One of the components of the drug - Omeprazole - Is a drug that inhibits gastric acid secretion by inhibiting the enzyme, which is contained in the membranes parietal cells gastric mucosa. It also reduces basal and stimulated secretion . After taking the capsules once effect occurs within one hour and lasts throughout the day. The secretory activity after omeprazole recovered after 3-5 days.
Clarithromycin It is antibiotic Belonging to Groups macrolides . It is a semisynthetic derivative erythromycin A . It acts as an antimicrobial agent by inhibiting microbial protein synthesis. When ingested formed metabolite, 14-hydroxyclarithromycin Which is also effective against many microorganisms.
Amoxicillin - A semisynthetic Penicillin That acts as a broad spectrum germicide. It inhibits the synthesis of peptidoglycan during growth and division.
All components of the complex Pilobakt AM have good absorption after oral administration.
Omeprazole absorbed in a very short time. Report mostly in the urine. Its bioavailability - about 35% regardless of mealtime. The maximum drug concentration in plasma - after 30-60 minutes after application. Communication with plasma proteins - 90%. Omeprazole is almost completely broken down in the liver.
Clarithromycin well and in a short time it is absorbed from the gastrointestinal tract. When used on an empty stomach tablets maximum serum concentration is achieved within 2 hours. Eating slows down the formation of metabolites. The absolute bioavailability of the drug - about 50%. The half-life - 3-4 hours. The drug is widely distributed when ingested. Its concentration in tissues than in the serum. Communication with fibers - 70%. Clarithromycin is excreted in the kidneys and feces unchanged and metabolites . The complex Pilobakt AM average value of its maximum concentration is increased by 10% and the minimum concentration - by 15% compared to monotherapy.
Amoxicillin in a short time it is absorbed from the gastrointestinal tract. Its bioavailability - about 80%. Mealtime does not influence the effect of this drug. Means in a short time is distributed in the tissues. Half-life - 60-90 minutes. Relationship to plasma proteins - 20%. Is displayed for about 60% of the drug in the urine in unchanged form, the remainder - with the feces.
Indications
Complex Pilobakt AM prescribed for eradication therapy Helicobacter pylori people suffering from duodenal ulcer .
Contraindications
The drug should not be taken if:
- hypersensitivity to its components, and macrolide antibiotics;
- pregnancy ;
- porphyria ;
- kidney and hepatic insufficiency ;
- childhood;
- Lactation .
Side effects
When using this tool, the following adverse reactions:
- Digestive system Nausea, goiter, flatulence, dry mouth, stomatitis, liver dysfunction, diarrhea / constipation, vomiting, abdominal pain, taste disturbances, coming increase in liver enzymes.
- Locomotor apparatus : Myalgia, muscle weakness, arthralgia.
- Circulatory system : Leukopenia, thrombocytopenia, anemia, neutropenia, thrombocytopenic purpura.
- Nervous system : Excitation, peripheral neuropathy, insomnia, headache, paresthesia, confusion, epileptic reactions, dizziness, drowsiness, ataxia, depression, hallucinations.
- Allergies : Angioedema, urticaria, anaphylactic shock, bronchospasm.
- Other: blurred vision, tachycardia, sweating, gynaecomastia, interstitial nephritis, peripheral edema, fever.
In rare cases, erythema multiforme exudative . skin rash . pseudomembranous enterocolitis . alopecia . photosensitization .
Instructions for use (method and dosage)
The drugs included in the complex Pilobakt AM, taken orally.
Each strip is designed for the reception day and includes two sets of morning and evening (red and blue).
In the morning take capsules of omeprazole, amoxicillin and 2 capsules 1 tablet Clarithromycin. At the evening reception the same dosage.
Capsules and tablets should not be chewed or crush, they must be swallowed completely. The course of treatment is calculated for a week.
Overdose
Drug overdose has not been described.
Cooperation
Omeprazole in combination with Phenytoin . Warfarin and Diazepam can slow their elimination. It also affects the absorption Ketoconazole , Iron salts, and Ampicillin .
In conjunction with increasing the concentration of Clarithromycin Theophylline . Carbamazepine . Phenytoin . Lovastatin . Cisapride . Astemizole . Cyclosporine . Dizopiramid . valproate . Pimozide and Digoxin So strict control dosages. And when taking in conjunction with the Terfenadine possible not only to increase its concentration, but also lengthening QT interval.
In the case of heart disease in history it is not advisable to combine with Clarithromycin Terfenadine . Astemizole and Cisapride . Reception with oral anticoagulants may result in potentiation of their effect. Co-administration with indirect anticoagulants It must be accompanied by the control protrombinovannogo time.
Amoxicillin conjunction with oral contraceptives can reduce their effectiveness.
Terms of sale
The tool is sold in pharmacies by prescription only specialist.
Storage conditions
Pilobakt AM must be kept in a dry place with a temperature above 25 ° C.
Shelf life
Store this medication should be no longer than two years.
Reviews Pilobakt AM
Generally, reviews of Pilobakt AM found mostly positive. Many patients praise the swift action of the drug industry. It is great help for ulcers and it is very rarely gives any side effects.
Price Pilobakt AM where to buy
Price Pilobakt AM just above 1,000 rubles. In some pharmacies cost can be less.
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