Description overdue on 08/12/2014
- Latin name: Monopril
- ATC code: C09AA09
- Active substance: Fosinopril (Fosinopril)
- Manufacturer: BRISTOL-MYERS SQUIBB (Italy)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Monopril (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet Monopril depending on dosage may contain 20 or 10 mg fosinopril sodium as the active substance.
Additional material: crospovidone, microcrystalline cellulose, lactose, polyvinylpyrrolidone, sodium stearyl fumarate.
Product form
Monopril - a white, round, biconvex tablets, odorless, with a notch at one end and engraved "609" or "158" on the other.
Produced by:
- 14 tablets of 20 mg per blister, two blisters in the paper bundle;
- 10 tablets of 10 mg per blister, plastic and aluminum foil, one or two blisters in the paper bundle;
- 14 of 10 mg tablets in a blister pack made of plastic and aluminum foil, one or two blisters in the paper bundle.
Pharmacological action
The drug has hypotensive action.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Angiotensin converting enzyme inhibitors. Chemically fosinopril sodium - Fozinoprilata ether sodium salt.
Fozinoprilat It is a selective blocker of competitive angiotensin-converting enzyme . After inhibition of ACE, it prevents the transformation angiotensin first type angiotensin the second type having vasopressor action. This leads to a decrease in the content of angiotensin a second type in the blood - this leads to a decrease in its vasoconstrictor activity and secretion loosening aldosterone .
Fozinoprilat hampers the exchange of bradykinin and therefore the antihypertensive effect is enhanced. Reduced pressure is not accompanied by a decrease or an increase in circulating blood volume, renal and cerebral blood flow, blood supply to organs. After an internal reception antihypertensive effect occurs within one hour, becomes maximum after 2-5 hours and lasts about one day. A few weeks necessary to achieve the maximum therapeutic effect.
Antihypertensive effects of thiazide diuretics and fozinoprila They complement each other.
The drug reduces the sensitivity to physical activity, decrease the severity of heart failure.
Pharmacokinetics
After oral administration the absorption from the intestine reaches 30-40% and is independent of the meal. The maximum plasma concentration occurs within three hours. The interaction with blood proteins is 95%.
Enzymatic hydrolysis of the drug in the liver and intestinal mucosa. Fozinoprilat It appears equally through the digestive tract and the kidneys. The half-life is close to 11 hours.
Indications
Indications Monoprix:
- heart failure ;
- hypertension (both as monotherapy and as part of a combined treatment).
Contraindications
- Angioedema .
- Hypersensitivity to any component of the formulation.
- Age 18 years.
- Pregnancy and lactation.
Be wary of:
- hyponatremia ;
- Bipolar renal artery stenosis ;
- desensitization;
- aortic stenosis;
- condition after undergoing a kidney transplant;
- renal failure ;
- Systemic connective tissue disorders;
- hemodialysis;
- cerebrovascular diseases;
- coronary heart disease ; Heart Failure Chronic type of grade 3-4;
- diabetes ;
- hyperkalemia ;
- suppression of hematopoiesis in bone marrow;
- gout ;
- in old age;
- state, accompanied by a decrease in circulating blood volume.
Side effects
The most likely side effects of Monopril.
- From the circulatory system: chest pain, fainting, orthostatic hypotension , Hot flushes, arrhythmia .
- From the digestive system: vomiting, dyspepsia, pancreatitis , Increase content ALT and AST . hepatitis .
- From the nervous system: sensory disturbances, fatigue.
- With the genitourinary system: oliguria, proteinuria , Increasing the concentration creatinine and urea .
- From the side of respiratory system: sinusitis, pharyngitis , Cough, bronchospasm .
- From the musculoskeletal system: pain in joints and muscles.
- Allergic reactions: photosensitization . itch . rash . angioedema .
Instructions for use Monopril (method and dosage)
Instructions for use Monopril recommends taking the drug inside. The dosage is adjusted individually.
Hypertension . Starting dose - 10 mg once a day. Pick up the dose should be watching the dynamic pressure reduction. The standard dose is in the range 11-40 mg once a day. If sufficient hypotensive effect is not possible to further designate diuretics .
Heart failure . The initial dose of - 5 mg up to two times per day. Over time, the dose is permitted to increase up to 40 mg per day.
Overdose
Symptoms: severe reduction in pressure, bradycardia, shock , Disruption of water and mineral balance, acute course renal failure, stupor.
Treatment: stop taking Monopril, gastric lavage, the use of sorbents, vasopressor agents , Intravenous administration of saline, then symptomatic and supportive therapy. Hemodialysis ineffective.
Cooperation
Simultaneous use with antacids reduces the absorption of fozinoprila , So they should be consumed with an interval of 2 hours.
In a joint application with lithium salts increased risk of toxicity lithium .
Nonsteroidal anti-inflammatory agents inhibit antihypertensive Monoprix and the action of these drugs.
When using the drug with diuretics may develop an excessive pressure drop.
Formulations containing potassium and potassium-sparing diuretics increase the likelihood of hyperkalemia .
Fosinopril activates hypoglycemic effect insulin and derivatives sulfonylureas ; increases the risk of leukopenia when used with cytostatic agents, immunosuppressants, allopurinol, procainamide.
Estrogens inhibit antihypertensive Monoprix effect.
Terms of sale
The drug is available by prescription.
Storage conditions
Store in a dry place in a temperature range of 15-25 degrees. Keep away from children.
Shelf life
Two years.
Cautions
Does not require correction dose received fozinoprila the elderly. Safe use in children has not been established.
You must be careful when driving, since it is possible the emergence of dizziness, especially in the initial stages of treatment.
Analogs of Monoprix
Renitek
Charter
Fozikard
Amprilan
Ramipril
Perindopril
Prestarium
Perineva
Capoten
Berlipril
Akkupro
Diroton
Enap
Enalapril
The most common analogs Monoprix: Fozikard . Fozinap, Fozinotek, Teva-Fosinopril.
Babies
The drug is contraindicated for use in children.
During pregnancy (and lactation)
Gestation and lactation a contraindication for treatment Monoprilom.
Reviews Monoprile
Reviews Monoprile indicate that the drug regimen should be adjusted in each case depending on the nature of the disease and individual characteristics. Based on these estimates, we can conclude that the drug is more effective in the complex therapy.
Price Monoprix where to buy
Price Monopril 20 mg №28 in Russia is around 309-430 rubles, Ukraine - 173-273 hryvnia.
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