Description overdue on 07/12/2014
- Latin name: Parlazin
- ATC code: R06AE07
- Active substance: Cetirizine (Cetirizine)
- Manufacturer: EGIS Pharmaceutical factory JSC (Hungary)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Parlazina (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Reviews
- Price, where to buy
Composition
Cetirizine dihydrochloride - The active ingredient of the drug. Drops also contain the following adjuvants: glycerol, sodium saccharin, methyl parahydroxybenzoate, glacial acetic acid, propylene glycol, sodium acetate trihydrate, propyl parahydroxybenzoate, purified water.
Tablets Parlazin incorporate such additional substances as Colloidal anhydrous silica . lactose monohydrate . magnesium stearate . MCC . Their shell contains hypromellose, macrogol 400, titanium dioxide, ariavit "Sunset" yellow.
Product form
Method of production of the drug - pills and drops .
Pharmacological action
Antiallergic means.
Pharmacodynamics and pharmacokinetics
Active component of the drug is a selective antagonist of H1-histamine receptors . It has antihistamine action and belongs to the group of piperazine . It affects cell inflammation by blocking factors chemotaxis of eosinophils and preventing migration eosinophils . It reduces congestion eosinophils in the skin, as well as reactions to histamine . It inhibits other inflammatory cells infiltration .
Parlazin prevents and relieves symptoms allergies It is protivoekssudativnoe and antipruritic properties. In addition, it reduces the permeability capillaries , Removes spasms of smooth muscles and prevents swelling .
Preparation action begins 20 minutes after application. The maximum effect is achieved in an hour. The action of the drug lasts for days.
Absorbent the drug is rapidly and completely. Meals have only a minor impact on its operation.
The degree of coupling protein - 93%. Not biotransformed in the liver. Half-life generally about 8 hours in children - shorter (5-6 hours, depending on the age), and the elderly, on the contrary - is longer by about 50%. In addition, it can increase in the presence of renal failure .
60% of the active substance is excreted in the urine in unchanged form within a day. Another 10% of the drug is released over the next 4 days. Since feces derived 10% in 5 days. The drug passes into breast milk.
Indications
The drug is given to those who suffer from allergies (seasonal and chronic outbreaks). It prevents its manifestation, reduces discomfort, making sluggish. Since this tool helps with hives . angioedema . dermatitis . hay fever . You can apply at Parlazin asthma as a component of complex therapy.
Contraindications
You can not use the medicine if:
- pregnancy ;
- children aged up to one year (up to 6 years for tablets);
- breast-feeding ;
- hypersensitivity to the components.
Precautions should be used drug in chronic renal failure severe to moderate, and in the elderly. In both cases, a dosage adjustment.
Side effects
As a rule, the tool is well tolerated. Side effects may include: drowsiness . headache . dizziness , Nausea and other adverse reactions from the gastrointestinal tract, increased fatigue, migraine , Dry mouth, anxiety .
Manifestations of the side effects can be reduced by dividing the daily rate by two steps.
It is also possible hypersensitivity reaction to one of the components of the drug, for example, vascular edema or rash But they occur in rare cases.
Instructions for use Parlazina (method and dosage)
Prior to use of the drug it is necessary to consult with your doctor.
Adults appoint 10 mg per day. Instructions on pills Parlazin reports that it is 1 tablet per day. Take needed orally While drinking plenty of fluids. This dosage is also calculated on 20 drops. The medicine should preferably be taken at night. The daily dosage can be equally divided into two steps.
Children from 2 to 6 years is prescribed 5 mg per day. For those taking drops Parlazin, instruction on the application reports that the daily dosage is designed for 10 drops. It's also half a tablet. The dose can be divided into two steps. Children from 1 to 2 years should receive 5 drops (2, 5 mg) twice a day. And for children aged 6 to 12 years: 5 mg 2 times a day for the reception in the morning and evening (10 drops or poltabletki). Furthermore, they can take 10 mg once a day (preferably in the evening), this corresponds to a tablet or 20 drops.
Instructions on Parlazin recommends that elderly patients and people with renal failure to reduce the daily dosage is 5 mg. Tablets should be taken orally . Drops to receive water soluble.
Overdose
In applying the drug in high doses may fatigue and drowsiness . Children tend to primarily occur anxiety and irritability . When you receive an increased dose can appear only once delays in urinating and constipation .
In case of overdose should be cause vomiting, stomach wash. Symptomatic therapy. Hemodialysis is not effective, and specific antidote does not exist.
Cooperation
When combined with drugs Theophylline at a dose of 400 mg of a decrease in the total clearance Parlazina active substance of 16%.
Terms of sale
The drug is sold in all its forms without a prescription.
Storage conditions
The tablets should be stored in the tool away from children at a temperature of 25 ° C.
In the form of drops of medication should be kept protected from sunlight, out of reach of small children. Optimum temperature 25 ° C.
Shelf life
A preparation in the form of tablets stored no longer than two years. Do not use it beyond the expiration date.
Drops out of 4 years. Open the vial may be held for no longer than 4 weeks.
Reviews Parlazine
According to reviews, the tool quickly to cope with Allergies It has a convenient dosing and a very pleasant taste. It is easy to use even when allergies in young children. Reviews of drops for children also reported that they often advise the pharmacy pharmacists or pediatricians prescribe. What particularly like their parents, is that this tool is included in the list of free drugs for children up to 3 years, and the packaging is completely safe for the kids.
On the negative side reviews of Parlazine sometimes talk about the appearance of adverse reactions. For some it means simply is not suitable as it does not have any effect. Perhaps, in this case more appropriate to use Neo Parlazin . In addition, patients have noted that it is quite expensive means to be used simply as a preventive measure. All the more so after opening the package, the droplets are kept short.
Price Parlazina where to buy
Parlazina price may vary depending on the form of. The cost of the tablets 5 pieces per pack - about 65 rubles. Price Parlazina in packaging designed for 10 units - 120 rubles. A tablet of 30 pieces in one pack cost about 260 rubles. Price drops an average of 260 rubles.
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