Description overdue on 09/11/2014
- Latin name: Neurobex Forte
- ATC code: A11DB
- Active substance: Thiamine nitrate, or vitamin B1 + Pyridoxine hydrochloride or vitamin B6 + cyanocobalamin or vitamin B12 (Thiamine + + Ryridoxine Syanocobalamin)
- Manufacturer: Balkanfarma AT-Dupnitsa, Bulgaria
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Neurobeks Forte (method and dosage)
- Overdose
- Cooperation
- Cautions
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
The preparations contain the active ingredients: thiamine nitrate - 100 mg pyridoxine hydrochloride - 200 mg cyanocobalamin - 300 micrograms.
Auxiliary components: Avicel PH101, talc, magnesium stearate and aerosil.
Coated tablets consists of methocel E5 and E15 Premium, polyethylene glycol 6000, titanium dioxide (E171), liquid silicone AK 200/350, dye Sunset Yellow 19% (E110) and quinoline yellow dye 11% (E104).
Product form
Available Neurobeks Forte as a slightly convex tablets in a foil envelope orange. The package includes a 30 or 60 pieces.
Pharmacological action
Neurobeks Forte is a multivitamin complex that includes in its membership vitamins Group B.
Pharmacodynamics and pharmacokinetics
The effect of this drug due to properties characteristic of its constituent vitamins.
Getting in the human body, thiamin undergoes phosphorylation, transformed into kokarboksilazu - Coenzyme participating in most enzymatic reactions. Thiamine is necessary for the full implementation of the carbohydrate, protein and fat metabolism, carrying nerve impulses in the synapses. With a lack of this substance observed hoarding Breast and pyroracemic acid That is the main cause of polyneuritis, Korsakoff's syndrome, Wernicke's encephalopathy , Abnormality of the heart, digestive tract, and so on.
Importance pyridoxine It is in direct support of the nervous system. Undergoing phosphorylation vitamin B6 It is converted to coenzyme required for metabolism amino acids and other enzymes located in the nerve tissues. Also this component is involved in the biosynthesis of neurotransmitters : norepinephrine, epinephrine, serotonin, histamine, gamma-aminobutyric acid . The reason for the deficit pyridoxine Malnutrition is, variations in the gastrointestinal tract, taking certain medications, which are its antagonists . It may evolve glossitis, stomatitis, convulsions, peripheral neuritis, anemia and other violations.
Cyanocobalamine participates in the process of hematopoiesis, maturation erythrocyte Biochemical reactions that provide the vital activity - production of nucleic acids, proteins, the transfer of methyl groups exchange amino acids, lipids and carbohydrates . Also noted a beneficial effect on the nervous system, the replication and growth of cells. On the lack of B12 may indicate symptoms that affect activities of the hematopoietic and nervous systems that can lead to serious complications.
B vitamins that make up the complex are water-soluble substance that prevents their accumulation in the body.
Absorption pyridoxine and thiamine dose-dependent and occurs in the upper intestine, and then uniformly distributed in the body.
Cyanocobalamine It absorbed in the upper intestine and stomach, which advantageously determines the presence of intrinsic factor. Receipt of this vitamin in the fabric performs transport protein Transcobalamin II.
The process of metabolism thiamine, pyridoxine and cyanocobalamin in the liver.
Withdrawal of the drug from the body is through the intestine, bile and small part with the help of the kidneys.
Indications
The main indications for Neurobeks Forte are:
- various forms polyneuropathy - Diabetic, alcohol, drug and toxic;
- sciatica, lumbago;
- neuritis, neuralgia;
- plexitis;
- radicular syndrome Which cause degenerative changes of the spine and so on.
Contraindications
Not recommended to prescribe the drug if:
- acute thromboembolism;
- polycythemia, eritremii;
- lactation, pregnancy;
- the age of 18;
- hypersensitivity.
Side effects
When taking these pills may experience nausea, itch . tachycardia and urticaria.
Instructions on Neurobeks Forte (method and dosage)
It should be noted that Neurobeks Fort instructions for use recommends only accept adult patients. The daily dose is - one tablet 1-3 times to the reception. Take tablets after meals, as a whole, with some liquid. As a rule, the treatment specialist sets, but on average it could be 2-3 weeks.
Overdose
In cases of overdose often develops: jitters, heart pain, tachycardia.
This is the treatment of gastric lavage, reception Activated Carbon , The use of other symptomatic treatment. Also remember that isoniazid - It antidote vitamin B6.
Cooperation
The simultaneous use of the drug and levodopa it lowers the efficiency of anti.
Admission with anticonvulsants, for example, phenobarbital, carbamazepine, phenytoin May cause deficiency thiamine.
The combination colchicine, biguanide and Neurobeks Forte reduces absorption cyanocobalamin.
During treatment with this drug should refrain from receiving the other multivitamin complexes that make up the B vitamins
Cautions
Caution is advised to take this set of patients with complicated forms angina and decompensated heart failure.
Reception of high doses of the drug should not continue for more than 4 weeks. The fact that increased dosage of vitamin B6 can cause peripheral sensory neuropathy Which eliminates the abolition of the drug.
Terms of sale
The drug belongs to the media without prescription.
Storage conditions
For storage of vitamin preparations meant dark, dry place inaccessible to children at a temperature of 25 ° C.
Shelf life
2 years.
Analogs
Neurobeks
Milgamma
Milgamma Compositum
Neyrorubin
Such actions also possess drugs: Neurobeks, Neurobeks Neo Milgamma, Aevitum, Citoflavin, Neyrorubi n and others.
Alcohol
The combined use of Neurobeks Forte and ethanol can dramatically reduce the absorption thiamine Almost 30%.
Reviews of Forte Neurobeks
Various vitamins and vitamin complexes are very popular in the society. As a rule, they are taken by women. At the same time reviews of Forte Neurobeks show that it is quite effective drug to normalize overall health, and provides significant support in certain cases.
According to experts, the effectiveness of this tool confirmed practical application. However, one receiving vitamins may not be enough, because the body often requires an integrated approach: proper nutrition, an active lifestyle, the use of suitable cosmetics and so on.
To support health after suffering diseases should not appoint themselves the vitamins alone, as often it is necessary to take into account their interaction with drugs. Therefore, the choice of vitamin complexes is best done together with your doctor.
Price Neurobeks Forte, where to buy
The cost of the drug at pharmacies in Ukraine is 107-120 UAH.
In Russia, the online pharmacy you can buy Neurobeks Forte as low as 320 rubles.
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