Description overdue on 11/30/2014
- Latin name: Aleron
- ATC code: R06AE09
- Active substance: levocetirizine hydrochloride
- Manufacturer: Emcure Pharmaceuticals (India)
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Synonyms
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As part of the tablets contained levocetirizine dihydrochloride as active ingredient, and also further constituents: lactose monohydrate, magnesium stearate, corn starch, sodium starch glycolate (type A), microcrystalline cellulose, colloidal silicon dioxide.
Product form
Aleron is available in tablet form, which covers the shell. In a blister pack - 10 tablets in cardboard packaging - 1 or 3 blisters.
Pharmacological action
Antiallergic agent, which belongs to the group of antihistamine medications 3 generations. The active substance Aleron, levocetirizine , R-enantiomer of cetirizine. This substance - active substance hydroxyzine. Medicine provides antipruritic, antiallergic, antiexudative, anti-inflammatory effect on the body. It is also noted pronounced antihistamine influence. Levocetirizine blocks peripheral histamine H1-receptors and prevents histamine release due to the stabilization of mast cell membranes. There is a high selectivity with respect to levocetirizine H1 histamine receptors, expressed by the blocking effect in relation to them.
For serotonin and M-cholinergic receptors drug has no effect.
To achieve clinical effects, rather twice less levocetirizine compared with cetirizine because levocetirizine forms a bond with the receptors expressed. Under the influence of the drug decreases production of chemokines and proinflammatory cytokines, inhibits adhesion and chemotaxis of eosinophils, the expression of adhesion molecules. Under the influence of levocetirizine is reduced IgE-dependent release of histamine, prostaglandin D2, leukotriene C4. The drug is also a depressing effect on the skin and trombotsitoaktiviruyuschy factor.
As a consequence, tablets Aleron can significantly alleviate the severity of a variety of allergic reactions (including nasal allergy ). People who suffer from seasonal allergies, can use this medicine as a way to prevent allergic reactions.
The tool is effective in forms cold urticaria At asthma . This levocetirizine does not suppress the central nervous system, it does not affect toxic to the heart.
Pharmacokinetics and pharmacodynamics
After oral agent is rapidly absorbed from the gastrointestinal tract, its absorption of the impact of food intake has almost no, only to some extent reduces the rate of absorption. The level of bioavailability of levocetirizine is 100%. The highest concentration of the active substance in the blood after 0, 9-1 hour, the blood is bound to proteins by 90%. A small part of the substance is metabolized in the liver, thereby forming an inactive metabolite. Half-life of the body - 7-10 hours. During the 96 hours it is completely eliminated from the body. Mainly eliminated via the kidneys, a small portion (approximately 13%) is derived from the human body through the intestines.
Indications
Appointed for the treatment and prevention of allergic diseases of acute and chronic. The drug is indicated for such diseases:
- conjunctivitis Allergic rhinitis;
- hives;
- hay fever;
- angioedema ;
- allergic dermatitis, in which the observed symptoms of burning, itching, rashes on the skin and mucous membranes.
Contraindications
You can not apply for the treatment of Aleron with such diseases and conditions:
- high level of sensitivity to the integral means and a piperazine derivative;
- renal failure, severe;
- galactose intolerance, malabsorption of glucose and galactose;
- up to 6 years.
Side effects
Likely side effects in the treatment of drug:
- Cardiovascular system : A sense of palpitations.
- CNS : Severe fatigue, drowsiness, headache, weakness, aggression, convulsions, anxiety.
- Hepatobiliary System : Hepatitis.
- Sight : Blurred vision.
- The immune system : Anaphylaxis, swelling;
- Respiratory system : breathlessness .
- GI Nausea, dry mouth.
- Skin : Urticaria, rash, itchy skin.
- Other manifestations : Abdominal pain, body weight gain, myalgia.
Instructions for use (method and dosage)
Instructions on Aleron provides that funds designated for adult patients as well as for children who have turned 6 years old. The tablets should be taken orally with a glass of abundant liquid. The dosage and duration of treatment determines the doctor depending on the diagnosis. Typically, 1 tablet of 5 mg once a day. The biggest dosage for an adult - 10 g of the drug per day.
Instructions for use Aleron provides that after brief contact with an allergen treatment lasts 7 days, if a person suffers from hay fever, the course of therapy may last for 3-6 weeks. If there is such a need, the course of therapy may last up to 6 months. The drug Aleron Neo take similarly.
People who suffer from renal impairment, the dose should be adjusted. When violations of the functions of the liver is practiced in the usual dosage.
Overdose
At high doses it means there was a strong state of drowsiness or overstimulation, which was subsequently replaced by sleepiness. It is necessary in the event of an overdose the patient to rinse the stomach, give him enterosorbent and then symptomatic treatment.
Cooperation
There was no interaction when used simultaneously levocetirizine and means, whose metabolism is associated with cytochrome P450. But multiple dose theophylline to some extent reduces the clearance of levocetirizine. It does not simultaneously receive Aleron and sedatives. Levocetirizine does not increase the impact of ethanol.
Terms of sale
Aleron is available without prescription.
Storage conditions
Aleron should be stored in a dry, dark place, and the temperature should not exceed 25 degrees Celsius.
Shelf life
You can store the drug for 2 years.
Cautions
Carefully appointed people suffering from renal insufficiency, elderly patients. Do not drink alcohol during treatment Aleron.
It is not recommended to interact with dangerous machinery, and transport control during treatment with this drug.
Synonyms
Ksizal
Analogs
Parlazin
Ksizal
Cetirizine
Tsetrin
Zodak
Zyrtec
There are a number of funds that are analogues of the drug Aleron. This medication Neo Aleron . Alerzin . Glentset . Tsezera . Ksizal . Tsetrilev and etc.
These drugs have a similar effect, but their use in specific diseases is possible only after the permission of a specialist.
Babies
There is no exact data on the efficacy and safety of Aleron for children under the age of six. Therefore, funds are designated only for children after 6 years.
During pregnancy and lactation
Sufficient data on the use of funds in the pregnancy and Lactation no. Aleron assigned pregnant cautiously only if the potential efficiency is higher than the potential risk. Levocetirizine passes into breast milk, so the period of treatment should stop breastfeeding.
Reviews Aleron
Feedback on Aleron rare. However, those who used these pills for treatment, noted that the drug effectively relieves allergy symptoms and relieves people suffering from such symptoms.
Price Aleron where to buy
Cost tablets Aleron is from 220 rubles in Russia you can buy it on request to Internet pharmacies. In Ukraine, the drug can be found in any drugstore. Price Aleron in Kharkov and other cities is 25 UAH. 10 tablets.
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