Description overdue on 10/13/2014
- Latin name: Solu-Medrol
- ATC code: H02AB04
- Active substance: Methylprednisolone (Methylprednisolone)
- Manufacturer: PFIZER MFG. BELGIUM, N.V. (Belgium)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions Solu-Medrol on
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- Newborns
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One vial of the drug Solu-Medrol contains 250, 500 or 1000 mg methylprednisolone .
Excipients: sodium phosphate, monobasic sodium phosphate monohydrate.
Solvent: benzyl alcohol Water.
Product form
Solu-Medrol - a lyophilisate for the manufacture of a solution for injection in the form of a porous mass or a white powder.
250, 500 or 1000 mg of the powder in the vial, the vial one paper packaging.
Pharmacological action
Solu-Medrol has glucocorticoid action.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Solu-Medrol - form metilirednizolona for intramuscular or intravenous administration. Metilirednizolon It penetrates the cell membrane and binds to specific receptors in the cytoplasm. As a result, it activates the transcription of mRNA and synthesis of various enzymes. Have a strong effect on the process of inflammation and immune response, as well as protein, carbohydrate and fat metabolism.
The therapeutic effects of the drug:
- suppression phagocytosis ;
- reduction of immunoactive cells in the inflammatory focus;
- reduction in vasodilation;
- stabilization of lysosomal membranes;
- decrease the synthesis prostaglandins .
Pharmacokinetics
After applying methylprednisolone sodium succinate actively hydrolysed to form a free methylprednisolone . Maximum concentration in the blood occurs within 55-60 minutes after use. The clinical effect occurs within 5-7 hours after use. The half-life of the drug is 3-4 hours. Relationship to plasma proteins - 50-90%. The drug appears in hemodialysis.
Indications
- Acute nonspecific peritendinitis .
- Adrenal insufficiency and its complications.
- Subacute thyroiditis .
- Systemic lupus erythematosus .
- Ankylosing spondylitis.
- Adrenal hyperplasia.
- Periarteritis nodosa.
- Post-traumatic osteoarthritis.
- Rheumatoid arthritis.
- Synovitis at osteoarthritis .
- Bursitis .
- Epicondylitis .
- Psoriatic arthritis.
- Acute gouty arthritis.
- Systemic dermatomyositis.
- Goodpasture's syndrome.
- Erythema multiforme.
- Bullous dermatitis herpetiformis.
- Bronchial asthma .
- Seborrheic dermatitis.
- Contact dermatitis.
- Irit and iridocyclitis .
- Exfoliative dermatitis.
- Reactions hypersensitivity to drugs.
- Serum sickness.
- Eye shape Herpes .
- Optic neuritis.
- Keratitis .
- Allergic conjunctivitis.
- Ulcerative colitis .
- Loeffler's syndrome.
- Rear uveitis and choroiditis.
- Symptomatic sarcoidosis .
- Hemolytic anemia.
- Leukemia and lymphoma in adults.
- Spinal cord injury in the acute period.
- Congenital aplastic anemia.
- Swelling of the brain.
- Multiple sclerosis .
- Tuberculous meningitis.
- Trichinosis .
- Organ transplantation.
Contraindications
- System fungal infections .
- Hypersensitivity to the drug.
- The simultaneous use of a vaccine with Solu-Medrol in immunosuppressive doses.
- Lactation.
It is not recommended to use the drug in patients with myocardial infarction .
Side effects
- From the mineral metabolism: the delay of water and ions in the body, hypokalemic alkalosis , Sodium retention, increased excretion of potassium.
- From the circulatory system: changes in blood pressure, congestive heart failure , Arrhythmias.
- From the musculoskeletal system: myopathy, osteonecrosis, weakness, pathological fractures, osteoporosis . neuropathic atrophy, myalgia, vertebral compression fractures, arthralgia, tendon ruptures.
- From the digestive system: peptic ulcer . pancreatitis , Gastric bleeding, peritonitis . esophagitis Perforation, abdominal pain, dyspepsia . diarrhea Vomiting.
- The increase of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in blood.
- Skin: skin striae, angioedema . petechiae and ecchymosis , Reducing the pigmentation of the skin, rash, hirsutism, erythema, urticaria.
- On the part of metabolism: slow down the process of ossification and growth in children, increased appetite and sweating.
- From the nervous system: increased intracranial pressure, dizziness , Affective disorders, seizures, amnesia, mental disorders, psychotic disorders, anxiety, personality changes.
- From endocrine system: hypopituitarism, Cushing's syndrome, increase in demand insulin in patients with diabetes , Changes in the menstrual cycle, lipomatosis, diabetes.
- From the senses: cataract . glaucoma . exophthalmos, secondary ocular infections.
- Laboratory findings: hypocalcemia, elevated levels of blood urea dyslipidemia, increase of calcium in the urine.
- On the part of the immune system: infectious diseases, reaction hypersensitivity, bronchospasm.
- Other: fatigue, weakness.
Instructions Solu-Medrol on
The drug may be administered intravenously and intramuscularly to prepare a solution for the pre-specified by the scheme. Children must be administered low dose (but not less than 0, 5 mg / kg / day).
In addition to the primary therapy-threatening conditions: 30 mg / kg body weight / drip. The introduction of such doses is allowed to repeat after 4-6 hours within no more than two days.
Recommended treatment regimens
Systemic lupus erythematosus 1 gram per day / in for three days.
Rheumatic diseases 1 gram per day / for a period of not more than 4 days, or one month in grams / in for six months.
Edematous syndrome in glomerulonephritis 30 mg / kg every other day for four days or 1 gram per day in / for 3-7 days.
Multiple sclerosis 1 gram per day in / for 3-5 days.
Such doses must be administered for at least half an hour. In the terminal stage of cancer diseases (palliative care): 125 mg daily / once a day for no more than eight weeks.
Overdose
The syndrome of acute overdose has not been described. In chronic drug overdose may experience symptoms encountered in Cushing's syndrome .
Symptomatic therapy. No specific antidote. The drug is derived by dialysis.
Cooperation
Methylprednisolone could strengthen or weaken the effect of indirect anticoagulants.
Solu-Medrol may influence anticholinergics and cause severe myopathy.
Solu-Medrol increases the concentration of glucose in the blood, therefore it is necessary to adjust the dosing regimen hypoglycemic agents .
Aminoglutethimide can suppress adrenal function, and inhibit the endocrine changes caused by long-term drug therapy.
Diltiazem . ethinylestradiol , grapefruit juice, C iklosporin . tsiklofosfamil, macrolides slow metabolism Solu-Medrol and increase its concentration in blood.
Nonsteroidal anti-inflammatory agents when combined with Solu-Medrol increase the incidence of gastrointestinal bleeding.
Terms of sale
The drug can be purchased with a prescription.
Storage conditions
Store at 14-24 ° C. Keep away from children.
The solution preparation is fit for use in the two days of preparation.
Shelf life
Five years.
Cautions
When using Solu-Medrol should be careful to persons driving a car due to the likelihood of changes in the vision, dizziness and weakness.
Analogs
Flosteron
Depo-Medrol
Medrol
Diprospan
Kenalog
Analogues of the drug are: Metipred . Advantan, Metizolon, Sterokort .
Babies
Application of funds in children is possible only if absolutely indicated and under the close supervision of a physician.
Newborns
The drug should not be used in infants.
During pregnancy (and lactation)
During pregnancy or Lactation drug use is prohibited.
Reviews
The drug is positively characterized by doctors and patients when used according to indications and the necessary precautions.
Solu-Medrol price, where to buy
Solu-Medrol Price 1000 mg of Russian 733-1051 rubles, the average price of the drug in Ukraine is close to 640 UAH.
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