Description overdue on 06/20/2014
- Latin name: Fromilid
- ATC code: J01FA09
- Active substance: Clarithromycin (Clarithromycin)
- Manufacturer: KRKA (Slovenia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Fromilid (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Synonyms
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Fromilid as tablets It is composed of clarithromycin (active ingredient), and a number of auxiliary substances: anhydrous colloidal silicon dioxide, propylene glycol, corn starch, microcrystalline cellulose, talc, pregelatinized corn starch, hydroxypropyl methylcellulose, titanium dioxide, quinoline yellow dye, magnesium stearate.
Fromilid granulate for the preparation of oral suspension composition is in clarithromycin (active ingredient), and a number of excipients: Povidone, carbomer, castor oil, hydroxypropylmethylcellulose phthalate, xanthan gum, talc, citric acid, potassium sorbate, titanium dioxide, sucrose, flavoring, silica, colloidal anhydrous.
Fromilid-Uno , Prolonged exposure to the drug is composed of active substance clarithromycin And a number of auxiliary components: polysorbate 80, talc, povidone, sodium calcium alginate, magnesium stearate, sodium alginate, hydroxypropyl methylcellulose, lactose monohydrate, Quinoline yellow dye, titanium dioxide, anhydrous colloidal silica, propylene glycol.
Product form
Available in the form granules Which are used to prepare a suspension, is taken orally. The pellets contained in the vial by 60 mL, which accommodates 125 mg per one dose (5 ml). The bottle is enclosed in a cardboard box, attached to it dispenser.
Tablets Fromilid It covers film coating. One pack contains 14 tablets.
Tablets Fromilid-Uno They are oval, yellow, their covers the film coating. The package contains 5, 7 or 14 tablets.
Pharmacological action
Fromilid - this medicine, antibacterial agent that belongs to the macrolide group. It has a bacteriostatic effect on various microorganisms by inhibiting the production of protein in microbial cells. For some agents it has bactericidal effect.
The drug is effective against intracellular infektantami . Gram-positive and Gram-negative organisms . It also applies to all mycobacteria (exception - M. tuberculosis ) For some anaerobic .
Pharmacodynamics and pharmacokinetics
Antibiotic Fromilid Uno and Fromilid well absorbed after oral upotreleniya. The active ingredient quickly into the tissue, which were hit by inflammation, as well as in body fluids, where it is noted the concentration of which exceeds 10 times the concentration of the substance in the blood plasma.
The main metabolite is 14-hydroxy-clarithromycin . After ingestion metabolized about 20% of the administered dose. If the antibiotic was passed 250 mg clarithromycin Elimination half-life is 4 hours, if the dose was 500 mg, the average half-life is 6 hours. In unchanged form eliminated 20-30% of the material, the remaining amount is allocated as metabolites.
Indications
Fromilid Uno and Fromilid prescribed for the treatment of the following diseases:
- infectious diseases of the respiratory tract ( bronchitis . tonzillofaringit . sinusitis severe, otitis );
- infectious diseases of the skin and soft tissues ( mug . infections in wounds . boil . carbuncle );
- mycobacterial diseases;
- in complex treatment H. pylori infection ;
- preventive measures in relation to people with AIDS .
Contraindications
Do not take the drug in the following cases:
- When the manifestation of high sensitivity clarithromycin , Macrolide or other ingredients of medicaments.
- Can not be combined with reception Fromilid cisapride . terfenadine . pimozide . astemizole .
- The drug is contraindicated in severe kidney disease At porphyria .
Side effects
In most cases the side effects of the drug is expressed softly, his symptoms quickly disappear.
The following manifestations:
- The functions of the digestive tract Nausea, diarrhea, vomiting, abdominal pain, stomatitis, glossitis, taste alteration, elevated liver enzymes, in rare cases - cholestatic jaundice .
- The functions of the immune system : Displays a high sensitivity ( hives . anaphylactic shock and etc.).
- The functions of the nervous system : headache, dizziness . insomnia , Recurrent nightmares.
Instructions for use Fromilid (method and dosage)
The tablets should be swallowed whole Fromilid, drink a little water. Adult patients and children after twelve taking 250 mg twice daily after 12 hours. When treating sinusitis As well as serious infectious diseases to patients assigned to receive 500 mg twice a day every 12 hours. The course of treatment lasts from 1 to 2 weeks.
With H. pylori infection It assigned a part of complex treatment of 250-500 mg twice in 12 hours per day. The treatment lasts one week.
In the prophylaxis and therapy of diseases which are associated with the bacteria Micobacterium complex avium means need to be taken every 12 hours for 500 mg, the physician specifies the duration of treatment. If the need exists, the dose may be increased, however, should not be taken per day more than 2000 mg of agent.
For the treatment of children the dosage is calculated based on the fact that 15 mg of funds per each kilogram of body weight. Fromilid daily dose is divided into two doses every 12 hours. Acceptable daily intake facilities for children is 1000 mg.
Fromilid 125 suspension used to treat children. To prepare a suspension, it is necessary in a bottle with beads add 42 mg of boiled water. Children under the age of 12 shall be appointed at a dose rate of 15 mg agent per kilogram of body weight. The daily dose is divided into two doses every 12 hours. Fromilid slurry 250 is determined if necessary by means of the dispenser. The suspension is necessary to drink water. The day allowed intake of 1,000 mg.
Instructions for use Fromilid Uno 500mg Next: Tablets should be swallowed during the meal and drink some water. What is the dose should be used, and how much should last a treatment is determined individually.
Instructions on Fromilid Uno provided that when children 12 years and adults take 500 mg once a day, making it at the same time. In severe infectious diseases, the dosage may be increased to 1000 mg per day. The treatment lasts from 1 to 2 weeks.
Overdose
In case of overdose may experience those symptoms that are side effects when receiving funds. The person may complain of Headache . pain in the abdomen . vomiting . Sometimes there is confusion. As treatment using gastric lavage, symptomatic treatment is appointed.
Cooperation
When you use both for treatment and Fromilid Warfarin or other anticoagulants should be carefully conduct the control of prothrombin time.
Fromilid not be appointed concurrently with drugs Pimozide . Terfenadine . Astemizole . Cisapride .
If at the same time being treated with drugs fromilid Theophylline . Carbamazepine . Midazolam . Tacrolimus . Digoxin . Lovastatin . Triazolam . Phenytoin . Simvastatin . Cyclosporine , and ergot alkaloids , It is necessary to strictly control the concentration of active substance in the blood of these means.
At simultaneous reception clarithromycin and zidovudine reduced absorption of zidovudine. Fromilid-Uno if the treatment is not recommended to prescribe AZT.
When combined with the reception Fromilid ritonavir Clarithromycin is significantly increased level in serum, while there is a strong decrease 14-hydroxy-clarithromycin .
Under the influence of clarithromycin not change the blood concentration of hormone components of oral contraceptives.
Terms of sale
For sale in pharmacies by prescription.
Storage conditions
Store medicines in a dry place at a temperature not exceeding 25 ° C. Protect children from the drug.
Shelf life
Shelf life and Fromilid Fromilid Uno - 3 years.
Cautions
After treatment fromilid patient may manifest cross-resistance to other antibiotics of microorganisms belonging to the macrolide group. If a person observed minor violations in the kidneys, the dosage of the drug does not change.
With porphyria agent is not appointed.
During treatment Fromilid to change gut microbiota and as a result, the appearance of microorganisms resistant to clarithromycin. People who have seen in the treatment of prolonged severe diarrhea, you should go and study excluded pseudomembranous colitis .
Patients with chronic liver disease must be carefully and regularly monitor the blood serum enzymes.
The tool has no effect on psychomotor reaction while driving or working with the precise mechanism.
Synonyms
Aziklar . Klaritrosin . Protex . Binoklar . Klabaks . Klarbakt . Clarithromycin . Klatsid . Clarithromycin-Verte . Klerimed . Klatsid CP . Lekoklar . Clarithromycin-Health . Klasan .
Analogs Fromilid
Klatsid
Klatsid CP
Rulid
Klabaks
Azitroks
Hemomitsin
Vilprafen
Rovamycinum
Roxithromycin
Clarithromycin
Azithromycin
Midecamycin
Sumamed
In pharmacies sold a number of analogs Fromilid and analogues Fromilid Uno. According to the composition and effects on the human body such analogues considered Erythromycin phosphate . Klatsid . Tetraolean . Klabaks . Kitasamycin . Eriderm . But before you replace any drug Fromilid, it is necessary to consult a doctor.
Babies
If the patient's age less than 12 years, for the treatment appointed Fromilid suspension for children. For the treatment of children under six years of age means not recommended, as the information about its security is not enough.
With alcohol
Simultaneous reception Fromilid and alcohol is not recommended.
During pregnancy and lactation
Not recommended for a treatment for pregnant women. In the first trimester use of agents is contraindicated. If the expected effect of the drug treatment outweigh the possible risks to the fetus and the mother can receive Fromilid in the second and third trimester.
Clarithromycin comes into breast milk, therefore breast-feeding for the treatment of drug should be halted.
Reviews Fromilid
Among those who took a course of treatment, reviews of Fromilid 500 mg most positive. Notes the fact that the agent is effective in the fight against infectious diseases, and that is assigned Fromilid even in emergency situations when there is no time for more research and the search for specific pathogens. The tool has a wide range of actions, so effective in many diseases. It is important to take it at the statutory scheme and find the right dosage for adults and children. As negative moments indicated very bitter taste of the drug, in some cases become an obstacle for the treatment, in particular pediatric patients.
Reviews on Fromilid Uno 500mg also mostly cheers. Side effects are rare, mainly treatment tool allows you to quickly get the expected effect.
Price Fromilid where to buy
The antibiotic can be bought at different prices depending on the dosage, the point of sale. Cost Fromilid 500 mg (14 pieces) in a network of pharmacies on average 560-600 rubles. Fromilid 250 mg (14 pieces) can be bought at the price of 350 to 400 rubles. Ukraine (Kiev, Kharkov and other cities) the price of the antibiotic is 110-120 UAH.
Cost Fromilid Uno 5 pieces per package. It is 240-260 rubles. Cost Fromilid Uno per pack 7 pcs. It is 270-330 rubles. Drug packaging 14 pcs. It will cost an average of 580-600 rubles.
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