Ì

Description overdue on 06.05.2012

Related Articles:

• Amoxicillin, instructions for use
• Instructions on Glyukofazh
• Price tablets Ferrum Lek
• Release form of budesonide

Tweet

Benzodiazepine tranquilizers . The active component acts diazepam . The mechanism of action is based on stimulation of benzodiazepine receptors. The drug has a central muscle relaxant, anticonvulsant, sedative, hypnotic effects. The impact on the amygdala in the limbic system has anxiolytic influence Reducing the severity of anxiety, fear, emotional stress, anxiety. Ì has sedative effects due to the impact on non-specific thalamic nuclei, reticular pharmacy brainstem. The drug reduces symptoms of neurological origin. The medicine inhibits brain stem cells reticular Pharmacy , Causing hypnotic effect   Relanium enhances presynaptic inhibition, providing anticonvulsant effect .  Diazepam does not remove the excitation in the epileptic focus, but inhibits the spread of epileptogenic activity .  Due to the inhibition of spinal polysynaptic afferent inhibitory ways muscle relaxant effect is achieved .  Sympatholytic effect leads to expansion of the coronary vessels, fall in blood pressure .  Ì is able to increase the pain threshold, suppressing vestibuoyarnye, parasympathetic, sympathadrenalic paroxysms .  The medicament reduces gastric acid secretion in the nighttime .  The effectiveness of the drug is 2-7 days of treatment .  Relanium not affect the productive symptoms of psychological origin (affective disorders, hallucinations, delusions) .  In chronic alcoholism, alcohol withdrawal ì leads to a weakening of tremor, agitation, hallucinations, delirium tremens, negativism .  Patients with paresthesias, arrhythmias cardialgia therapeutic effect is recorded at the end of the first week .  Ì produced in the form of tablets, solution, dragee .

Indications:

Relanium prescribed for anxiety disorders , Insomnia, dysphoria , Spastic conditions, skeletal muscle spasm with injuries, arthritis, bursitis, scoliosis, vertebral sidnrome , Chronic course of progressive polyarthritis, with tension headaches, angina, arthritis, rheumatoid pelvispondiloartrite. The drug is indicated for tension, anxiety, alcohol withdrawal, transient reactive states , Tremor of the extremities. The drug is administered in combination therapy in the treatment of psychosomatic disorders, ulcers of the digestive system, hypertension, status epilepticus, preeclampsia, menstrual disorders, menopausal disorders, eczema, irritability, Meniere's disease, poisoning by drugs. Before endoscopic manipulation, surgery Relanium prescribed as premedication . Parenteral Relanium administered for sedation prior to introduction into general anesthesia, myocardial infarction. The drug is actively used in psychiatry, neurology, to facilitate labor, premature placental abruption, premature labor.

Contraindications:

Relanium not prescribed for acute alcohol intoxication , Shock, coma, intolerance diazepam, acute medication poisonings, angle-closure glaucoma, myasthenia gravis, breastfeeding, severe COPD, absences, acute respiratory distress syndrome Lennox-Gastaut, during pregnancy. In epilepsy, spinal ataxia, renal disease, hepatic, cerebral ataxia, drug addiction, hyperkinesia, night apnea , Hypoproteinemia, diseases of the brain organic character, the elderly Relanium prescribed with caution, after prior consultation of experts.

Side effect:

Nervous system:   fatigue, dizziness, drowsiness, ataxia , Attention disorders, unsteadiness of gait, instability, disorientation , Lethargy, incoordination of movements, ecmnesia , Headaches, slower motor responses, tremor, depression, extrapyramidal disorder , Confusion, catalepsy, depressed mood, paradoxical reactions, agitation, hyporeflexia , Misteniya, weakness, ataxophemia , Cramping, suicidal tendencies, irritability, insomnia, severe agitation, hallucinations. Forming Organs : Agranulocytosis, anemia, thrombocytopenia. Digestive system:   hypersalivation, dry mouth, hiccough . heartburn , Nausea, gastralgia, constipation , Decreased appetite, increased levels of liver enzymes. Cardiovascular system:   drop in blood pressure, tachycardia , Palpitations. Urogenital: dysmenorrhea , Violation of libido, violation of the renal system, urinary retention, urinary incontinence . There may be allergic reactions such as itching, skin rash. The impact of the drug on the fetus Relanium: central nervous system depression, teratogenicity, violation of sucking reflex, disruption of the respiratory system. The injection site may develop phlebitis, venous thrombosis . Relanium calls medication dependency , Addiction, respiratory malfunction, diplopia, weight loss, bulimia, depression of the respiratory center. With a sharp lifting of the drug triggered "withdrawal": anxiety, headaches, irritability, anxiety, agitation, anxiety, dysphoria, sleep disturbances, nervousness, depersonalization, hyperacusis, perceptual disturbances, paresthesia, acute psychosis, hallucinations, convulsions, tachycardia, photophobia . Premature babies Relanium cause dyspnea, hypothermia, muscular hypotension.

Overdose:

Manifested confusion, drowsiness, decreased reflexes, paradoxical excitation, deep sleep, decreased response to pain stimulation, stunning, areflexia , Violation of visual perception, sleep apnea, severe weakness, shortness of breath, bradycardia, tremor, nystagmus, collapse, drop in blood pressure, respiratory depression, cardiac, coma. Therapy involves forced diuresis , Gastric lavage, enterosorbents maintaining bodily functions, mechanical ventilation. Specific antagonist flumazenil is used exclusively in the hospital. Flumazenil is not indicated in patients with epilepsy who take benzodiazepines (drug mzhet provoke epileptic seizure). Hemodialysis is not effective in overdose.

Mode of application:

Ì used rectally, intravenously, intramuscularly, .  The dose is calculated depending on the response to the drug, indication, the clinical picture of the main and co-morbidities, the patient's condition .  In psychiatry Relanium prescribed for phobias, dysphoria, hypochondriacal reactions, hysterical reactions, nervousness twice a day for 5-10 mg .  In some cases needs to increase the dose of 60 mg .  Alcohol withdrawal syndrome: the first day three times a day 10 mg of diazepam and then the number is reduced to 5 mg three times a day .  Patients with atherosclerosis, debilitated patients Relanium shown twice a day for 2 mg .  In practice, neurological degenerative diseases, spastic states diazepam administered 2-3 times a day for 5-10mg .  In rheumatology and cardiology: the treatment of angina, three times a day at 2-5 mg; arterial hypertension - three times a day to 5 mg; when vertebral syndrome - 4 times a day to 10 mg .  Myocardial infarction ì is shown in the complex therapy: the initial dose - 10 mg intravenously, and then prescribe medication 1-3 times a day for 5-10 mg .  With Defibrillation   premedication Relanium slowly injected in an amount of 10-30 individual doses. The initial dosage for vertebral syndrome, spastic states of rheumatic origin is 10 mg intramuscularly and then move on to receive the tablet form of the drug at 5 mg 1-4 times a day. With   gestoze , Menopausal disorders, menstrual disorders, psychosomatic disorders in gynecology and obstetrics: three times a day at 2-5 mg. To facilitate the opening of the cervix, facilitating the labor Relanium administered intramuscularly in an amount of 20 mg. Premature detachment of the drug is administered without interruption until the ripening of the fruit.

Special instructions:

Intravenous infusions of the drug must be ì exercise slowly for one minute every five milligrams (equivalent to one milliliter), preferably into a large vein. Not recommended incessant intravenous infusion because of the risk of absorption of the drug and precipitation. Unacceptable use of alcoholic beverages for the entire period of treatment. Long-term therapy, and pathology of the renal and hepatic systems requires level control liver enzymes , Blood picture. Ì Use of the drug in large quantities over a long period of time in patients with a history of drug addiction in addictive. It is strictly prohibited abrupt withdrawal of the drug. When the patient's feelings of fear, thoughts of suicide, anxiety, agitation, aggression, muscle cramps, hallucinations Relanium gradually overturned. Relanium toxic to the fetus, causing the formation of defects during the development.

Drug Interactions:

Relanium dampening impact neuroleptics , Antipsychotics, sedatives, ethanol, narcotic analgesics, Antidepressants , Muscle relaxants on the central nervous system. Inhibitors of microsomal oxidation (erythromycin, oral contraceptives, cimetidine, propoxyphene, propranolol . metoprolol . ketoconazole . fluoxetine , Disulfiram, valproic acid, isoniazid ) Enhance the effect of Relaniuma, extend its half-life. The opposite effect is observed in the application of inducers of microsomal enzymes in the liver system. Antacids   does not affect the completeness of absorption of diazepam, but reduce the rate of absorption. Antihypertensive drugs increase the severity of the fall in blood pressure. In the appointment of clozapine has increased, respiratory depression . In patients with Parkinson's disease Relanium reduces the effectiveness of levodopa. Under the influence of omeprazole is prolonged clearing time Relaniuma.