Description overdue on 08/14/2014
- Latin name: Levolet R
- ATC code: J01MA12
- Active substance: Levofloxacin (Levofloxacin)
- Manufacturer: "Dr. Reddy's Laboratories Ltd." (India)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Levolet P (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- With alcohol
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Each tablet contains 256 Levolet F, 233 mg. 512 or 466 mg. Levofloxacin hemihydrate Which corresponds to 250 mg., And 500 mg. active drug action levofloxacin .
As auxiliary compounds in the drug composition includes corn starch, crospovidone, Avicel PH 101 and Avicel PH 102 (MCC), colloidal silicon dioxide, hypromellose, magnesium stearate.
The shell contains a medicament White dye OY 58900 Opadry (macrogol 400, hypromellose 5 CP and titanium dioxide ).
In a 100 ml. Levolet P solution for infusion contains 512 ml. active compound levofloxacin Hemihydrate As well as such as the auxiliary connections Water for Injection (not more than 100 ml.), dextrose (5000 ml.) hydrochloric acid (0, 117 ml.) And sodium hydroxide (2, 857 ml.).
Product form
The drug release in the form of white biconvex tablets (250 or 500 mg) kapsulovidnoy forms coated with one side embossed «RDY», coated with a specialized coating.
Levolet P may be a transparent or pale yellow solution for infusion.
Pharmacological action
This drug has a broad spectrum of activity antimicrobial , and bactericidal properties.
Pharmacodynamics and pharmacokinetics
Drug compound, a member of the drug blocks topoisomerase II (DNA gyrase) and topoisomerase IV, thus breaking supercoiling Which starts the process of synthesis and "cross-linking" breaks DNA . Thus, the drug is Morphological transformation in the cytoplasm, the cell walls of , and membranes .
The drug is actively fighting anaerobic (Bacteroides fragilis, Veillonella spp.), aerobic Gram-positive (Staphylococcus spp., Corynebacterium diphtheriae.) and gram negative (Escherichia coli, Morganella morganii), and susceptible, moderately susceptible and resistant spoilage microorganisms.
The product is characterized by its linear character at reception. After ingestion of solution Levoleta P acts like a tablet form of the drug. Therefore intravenous or oral method of drug administration can be considered interchangeable.
This drug penetrates rapidly into the tissue of internal organs. Small amounts of drug may deacetylated or oxidized in the liver . Displayed drug compound using kidneys.
Indications
Such antibiotic as Levolet P is recommended for use with these infectious and inflammatory diseases :
- tuberculosis;
- bacterial prostatitis ;
- respiratory tract infections, urinary and kidney , including pyelonephritis ;
- intra-abdominal infections ;
- sinusitis;
- pneumonia;
- infectious diseases skin .
Contraindications
The drug is contraindicated in the presence of patients:
- Hypersensitivity to quinolones As well as the components of the drug;
- epilepsy;
- pregnancy ;
- age 18 years;
- defeat tendons ;
- lactation .
With great care the drug should be prescribed for older people, as well as patients with a deficiency of glucose-6-phosphate dehydrogenase.
Side effects
On the side circulatory, digestive, nervous, cardiovascular, urogenital and musculoskeletal system may experience the following side effects while using the medicine:
- leukopenia;
- anemia;
- nausea;
- goiter;
- stomach ache;
- diarrhea;
- hepatitis;
- loss of appetite;
- tachycardia;
- convulsions;
- vascular collapse;
- dizziness;
- drowsiness;
- depression;
- headache;
- paresthesia;
- trembling of the hands;
- the taste, sight, smell;
- aggravation of porphyria;
- worsening of renal function;
- tendon rupture;
- hypoglycemia;
- muscle aches;
- rhabdomyolysis.
In addition, use may provoke allergic reactions such as itching, rashes and redness of the skin, anaphylactic shock, fever, phlebitis, epidermal necrolysis, vasculitis, urticaria, Stevens-Johnson syndrome, hypersensitivity pneumonitis and others.
Instructions for use Levolet P (method and dosage)
It should be noted that the dosage of the drug, as well as dosing schedule depends primarily on the condition of the patient, the severity of the disease and the sensitivity of harmful microorganisms to the active substances. However, the average duration of treatment will be not more than 14 days.
In accordance with the instructions for use Levoleta 500 mg. and 250 mg. taking pills just before a meal or during breaks between meals, drinking plenty of water and without chewing. As is the case with other antibiotics Applying Levolet P advisable to start after a minimum of 48 hours eradaktsii harmful microorganisms As well as normalization of body temperature.
Adjustment of dosage of the drug is required in cases of treatment of patients with impaired kidney function .
Overdose
Failure to observe the dosage of the drug may manifest symptoms such as nausea, confusion, gastrointestinal mucosal damage, convulsions, increase the interval QT, and dizziness .
Cooperation
Reduces the efficiency of P Levoleta antacid drugs And in addition, preparations containing Sucralfate, a salt of iron, magnesium and aluminum. Should not be used together with the drug Cimetidine, theophylline, corticosteroids, NSAIDs and drugs that affect tubular secretion .
Terms of sale
Buy a cure is possible only on a doctor's prescription.
Storage conditions
This drug is banned frozen and should be stored in a dry place inaccessible to children, protected from light at a temperature not exceeding 25 ° C.
Shelf life
2 years.
Cautions
In order to avoid photosensitivity (skin damage) at the time of treatment should avoid both natural (sun) and artificial (solarium) UV radiation . When colitis , Signs tendinitis or allergic reactions should immediately stop using the drug.
In the presence of history of brain damage , It is worth remembering that in the treatment of patients Levoletom P may occur cramps, at deficiency of glucose-6-phosphate dehydrogenase increases the risk of hemolysis .
If you use this medication if possible you should avoid activities involving a greater concentration of attention, such as driving.
Analogs Levoleta P
Floratsid
Glewe
Avelox
Fleksid
Norbaktin
Tsiprinol
Ofloksin
TSifran
Tavanic
Nolitsin
Ofloxacin
The main structural analogues Levoleta P for an active action of the medicinal compound include:
- Ivatsin;
- Levofloks;
- Glewe;
- Levofloksabol;
- Leflobakt;
- OD Levoks;
- Remedy;
- Tanflomed;
- Ekolevid;
- Fleksid.
With alcohol
Levolet P as well as other antibiotics lose their distinctive properties of drugs with alcohol during treatment.
Babies
The drug may not be used in patients under 18 years of age.
During pregnancy (and lactation)
The drug is forbidden to take in the period Pregnancy and lactation .
Reviews Levolete P
Since the opinion on the effectiveness of the drug patients were divided in free sources can be found quite contradictory reviews Levolet 500 mg., 250 mg. and a solution for difuzy. On the one hand, people are talking about enough budgetary cost of the drug, and on the other - on the impressive list of side effects that give reason to doubt the benefits of the drug.
Price Levolet P, where to buy
Average price Levoleta 500 mg. (1 carton packs of 10 tablets) varies in the range of 300-400 rubles.
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