Description overdue on 09/24/2014
- Latin name: Concor
- ATC code: C07AB07
- Active substance: Bisoprolol (Bisoprolol)
- Manufacturer: Merck KGaA, Germany
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Concor
- Contraindications
- Side effects
- Instructions for use Concor (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet contains 5 mg Concor or 10 mg bisoprolol hemifumarate and bisoprolol fumarate in the ratio 2: 1 as active ingredients.
Excipients: calcium hydrogen phosphate, corn starch, colloidal silicon dioxide, microcrystalline cellulose, crospovidone, magnesium stearate.
The composition of the shell: hypromellose, dimethicone, iron oxide yellow, macrogol 400, titanium dioxide.
Product form
Concor tablets covered with bright orange envelope, heart-shaped, biconvex, with notches on both ends.
Method of production for Concor (dosage 5 mg and 10):
- Ten of these tablets in a blister, five or three such blisters in carton;
- or 25 of these tablets in a blister, such two blisters in a carton;
- or 30 of these tablets in a blister, a blister in a cardboard box.
For Concor 10 mg There is also the form of the following:
- 30 tablets in a blister, three of the blister in a cardboard box.
Pharmacological action
Concor - a drug which has antiarrhythmic, antihypertensive, anti-anginal action.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Medical drug Concor is selective beta 1-blocker Without sympathomimetic action. This drug is also not the honey has a membrane stabilizing effect.
Use of the drug Concor has no effect on the state of the respiratory tract and metabolic processes involving beta-2 adrenoceptor .
INN (international non-proprietary name) of the drug bisoprolol.
It does not have a strong negative inotropic effect. Lowers tone sympathoadrenal Suppresses beta 1-adrenergic receptors heart.
When one-time admission in patients with coronary heart disease without chronic heart failure bisoprolol reduces heart rate, stroke volume, ejection fraction and myocardial need for oxygen. When long-term therapy reduces elevated total peripheral vascular resistance.
The maximum effect occurs within three hours after administration. In appointing bisoprolol once daily its effect lasts for 24 hours. The maximum pressure drop recorded 12-14 days after initiation of therapy.
Pharmacokinetics
Bisoprolol absorbed from the intestine by 90%. Bioavailability - 90%. Receiving no food effect on the bioavailability. Concentrations bisoprolol in the blood plasma taken dose proportional in the range of 5-20 mg. The highest concentration in the blood occurs for 3 hours.
Plasma protein binding is close to 30%. All derivatives are excreted by the kidneys and is not pharmacologically active. The half-life is 11-12 hours.
Indications Concor
Indications for use of the drug:
- congestive heart failure ;
- coronary artery disease ;
- hypertension .
Contraindications
Contraindications Concor:
- acute form congestive heart failure;
- decompensated chronic heart failure;
- AV-block 2-3 degrees;
- cardiogenic shock;
- sinoatrial block;
- bradycardia;
- marked reduction of pressure;
- asthma and COPD;
- metabolic acidosis;
- severe changes peripheral blood circulation;
- pheochromocytoma;
- age less than 18 years;
- allergy to the drug.
Side effects Concor
Reviews of the side effects are not uncommon, the most frequently reported slowing heart rate, hypotension, nausea and deterioration of health.
- From the circulatory system: bradycardia , Deterioration of flow chronic heart failure , Numbness, severe reduction in pressure, orthostatic hypotension .
- From the nervous system and psyche: dizziness, loss of consciousness, headache, depression . insomnia , Nightmares.
- From the respiratory system: fit asthma .
- From the musculoskeletal system: convulsions , Muscle weakness.
- From the senses: hearing loss, conjunctivitis .
- From the digestive system: diarrhea , Nausea, vomiting, increased AST and ALT in blood.
- With the genitourinary system: potency disorders.
- Skin: alopecia .
- Allergic reactions: itching, rash, redness of the skin, nasal allergy .
Instructions for use Concor (method and dosage)
Instructions on Concor tablets prescribed to take the drug orally, once daily, in the morning. Instructions for use drugs also indicates that it should be washed down with a little water, without chewing.
With hypertension and angina dose of medication from the pressure Concor picked individually, taking into account the clinical condition of the patient and the disease. The initial dose of - 5 mg once a day. If it is necessary to increase at 5 mg once a day. In therapy hypertension and angina the highest recommended dose - 20 mg per day.
In chronic course Heart Failure regular regimen includes the use of ACE inhibitors or angiotensin blockers, diuretics, beta-blockers and cardiac glycosides.
A prerequisite for therapy with a stable chronic Heart Failure no exacerbations. The maximum recommended dose for the treatment of this pathology is 10 mg once a day.
Currently there are no sufficient data on the use of the drug in children, from which tablets Concor is not recommended for children under 18 years.
Along with the question of how to take Concor most often heard question is how long can I take the drug? Abstract does not limit the duration of treatment. Reputable online resources such as Wikipedia, and do not give clear guidance on the matter, saying only that the long-term course of treatment is determined by the attending physician.
It is not enough data on the use of the drug in patients with chronic heart failure, complicated diabetes the first type, severe liver and kidney function yl congenital heart disease with severe hemodynamic compromise, from which the medicine Concor in these patients should be prescribed with caution.
Overdose
Symptoms of overdose: bradycardia , Strong reduction in pressure, AV-block, bronchospasm, hypoglycemia and acute heart failure.
Treatment: stop taking the medication, start symptomatic therapy.
With bradycardia shown intravenous atropine . With strong pressure decrease - intravenous vasopressor drugs and plazmozameshchath solutions .
During exacerbation chronic heart failure - Introduction diuretics and vasodilators .
With AV-blockade - Appointment beta-agonists If necessary - to set the pacemaker.
With hypoglycemia - The introduction of the glucose solution.
With bronchospasm recommended the appointment aminophylline . β2-agonists .
Cooperation
Not recommended combinations:
Antiarrhythmics First Class when combined with bisoprolol can reduce conduction and cardiac contractility.
Antihypertensives Adopted with bisoprolol can cause bradycardia , Decreased cardiac output, and vasodilation .
Combinations requiring caution
Antiarrhythmics Class 3 (amiodarone) and parasympathomimetics enhance the AV-conduction disturbances.
β-blockers topical activate systemic effects bisoprolol .
Action hypoglycemic agents enhanced by using them with bisoprolol .
Cardiac glycosides when combined with bisoprolol lead to the development bradycardia.
Nonsteroidal anti-inflammatory agents reduce the hypotensive effect bisoprolol.
Application bisoprolol from non-selective agonists increases vasoconstrictor effects these tools, resulting in an increase in pressure.
Mefloquine when used with bisoprolol It may increase the possibility of developing bradycardia.
MAO inhibitors increase hypotensive effect of beta-blockers.
Terms of sale
Prescription.
Storage conditions
Keep away from children. Store at temperatures up to 30 ° C.
Shelf life
Five years.
Cautions
Not recommended abrupt abolition of the drug and alter the recommended dosage without consulting with a specialist, as this may cause a temporary deterioration of the heart.
Use caution in the following cases:
- diabetes with symptoms hypoglycemia ;
- holding desensitizing treatment;
- Prinzmetal angina ;
- strict diet;
- mild to moderate violation of the peripheral circulation by the arteries;
- AV-block the first degree;
- psoriasis .
Analogs Concor
Nebivolol
Biprol
Bisoprol
Concor Cor
Lokren
Niperten
Betaloc ZOK
Betalok
Coronal
Egilok
Nebilet
Atenolol
Metoprolol
Because of the relatively high price of the drug in patients is often the question arises: what to replace Concor. Bikard, Bisokard, Sandoz bisoprolol, bisoprolol, Apotex, bisoprolol-Maksfarma, bisoprolol-Richter, Bisoprofar, Bisostad, Kordinorm, Concor Cor, Coronal - This is just a small list of things to replace Concor.
There is also a Russian equivalent of Concor - a drug Biprol . The drug and its analogues are in different price categories; price analogs usually below. For example, the above-mentioned substitute Concor Biprol 5 mg №28 will cost 133-145 rubles, which is almost three cheaper drug from Merck same dosage.
Babies
The drug is not recommended for persons under 18 years of age.
With alcohol
Compatible Concor and alcohol frequent topic of discussion of patients receiving the tool. Alcohol is compatible with any little blockers due to the risk of orthostatic hypotension.
During pregnancy and lactation
The drug is not recommended during pregnancy and lactation unless the expected positive effects from the Concor exceed the risk to the child. Reviews in pregnancy do not report complications.
Reviews of Concor
Doctors about Concor tablets on the pressure a whole fit into the picture of the average statistical reports on beta-blockers. The drug has its own advantages and disadvantages.
Forums also contain enough drugs effectiveness evaluations. The most frequently asked question is whether the lower pressure tablets Concor? Also, be aware that the effectiveness depends strongly on the individual characteristics of each patient.
Nebilet or Concor - which is better?
Both drugs belong to the group of beta-blockers. Nebilet from a theoretical point of view has a strong vasodilator effect and with greater frequency causes undesirable effects (headaches) due to excessive vasodilating action. In this case, the drug of choice is Concor.
Egilok or Concor - which is better?
Similar virtually all indicators means. One preparation may be in the process of treatment can be easily replaced by another. 5 mg equivalent to 50 mg Concor Egilok.
Lokren or Concor - which is better?
Compared with Concor Lokren It has a prolonged effect, a greater affinity to the specific receptor and, therefore, the most stable concentration in plasma. Drug prices are comparable.
Coronal or Concor - which is better?
These funds are used interchangeably counterparts with the same active ingredient. Coronal more accessible from a financial point of view, so the choice between drugs should be carried out for reasons of economic expediency and the individual patient.
Bisoprolol or Concor?
The answer to the question "bisoprolol or Concor, which is better? "Identical to the previous answer. These drugs are analogous, but Bisoprolol It has a lower price.
What is the difference between Corinthians and Concor Concor?
The most common question the comparative effectiveness of drugs: differs from Concor Concor Cor ? Both preparations contain the active substance Bisoprolol . The main difference between drugs available tablet dose 2 mg in 5 Concor Cor.
Price Concor where to buy
Price Concor tablets of 10 mg in Ukraine №50 averages 162 hryvnia. In Russia, the price of Concor 5 mg №50 ranges from 306-340 rubles to buy 50 tablets of 10 mg will cost 463-575 rubles. The cost of the drug (5 mg №50) in Moscow starts from 263 rubles.
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