Description overdue on 07/17/2014
- Latin name: Valdoxan
- ATC code: N06AX22
- Active substance: Agomelatine (Agomelatine)
- Manufacturer: "Servier Laboratories Industry", France
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications agomelatine
- Contraindications
- Side effects
- Instructions on agomelatine (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
Tablets containing 25 mg of active substance - agomelatine in a single dose, as well as auxiliary substances: lactose monohydrate, magnesium stearate, corn starch, povidone, colloidal silicon dioxide, sodium carboxymethyl starch and stearic acid.
Foil shell consists of glycerol, hypromellose, iron oxide pigment yellow, macrogol and other components.
Product form
The drug release tablets oblong, covered with colorful foil wrapper with one-sided image of the company logo.
Pharmacological action
This medicine has antidepressant action .
Pharmacodynamics and pharmacokinetics
Agomelatine It is a substance having an antidepressive effect aimed at validated models Some depressions and other irregularities in the nervous system. At the same time preparations started based on it, do not have a strong negative impact on the activities of other body systems.
Receiving agomelatine It helps normalize sleep patterns, lower body temperature and improve the allocation of Melatonin . The drug can be used to treat disorders of the nervous system of varying degrees of difficulty, so may be as short-term and long-term therapy.
As a result, the internal reception absorption occurs quite rapidly and almost completely. The maximum concentration in plasma composition is achieved within 1-2 hours after administration of the drug. When distributing a substance inside the body is almost completely bound to plasma proteins, regardless of the drug concentration, the patient's age or the presence of disturbances in the kidneys. It is noted sufficiently rapid clearance of the drug from the body, primarily as metabolites using the kidneys. A small part of the unchanging substance also excreted in the urine.
Indications agomelatine
Treatment of severe and medium-sized depression adult patients.
Contraindications to the use of agomelatine
- intolerance to the drug;
- hepatic failure ;
- simultaneous treatment with powerful inhibitors of CYP1A2 isoenzyme ;
- patient age of 18 years;
- various forms of lactose intolerance.
In addition, the treatment is carried out with care of elderly patients with chronic diseases of internal organs, mental disorders, and so on.
Side effects
Generally, the manifestation of side-effects observed at the beginning of treatment. Very often patients are concerned: nausea, dizziness, drowsiness, headache, insomnia, fatigue, anxiety, sweating and so on. All these symptoms are not bright intensity and usually do not require additional treatment. Gradually, their expression is reduced and disappears completely.
Instructions on agomelatine (method and dosage)
Tablets are intended for oral administration regardless of food entirely - no crushing or chewing. If you have missed the next dose, additional medication is required, and the next tablet is taken as normal.
At the same instructions for use of agomelatine reports that need to be taken daily to 25 mg or 1 tablet. When for 2 weeks no improvement occurs may increase the dosage prescribed by the doctor.
During treatment it is necessary to perform control of liver function at the initial stage and then periodically throughout treatment. The average treatment course of 6 months or until the disappearance of unwanted symptoms.
Overdose
In the practice of medicine noted isolated cases of overdose agomelatine . This produces undesirable symptoms such as: drowsiness , Stomach pain, worry, anxiety, fatigue, stress, dizziness and so on.
If overdose is negligible, then the state will soon normalized independently, without abnormalities in the cardiovascular and nervous systems disorders in laboratory parameters.
If necessary, symptomatic treatment and control of the general condition of the patient.
Cooperation
Simultaneous treatment with this drug and different isoenzyme inhibitors, for example Fluvoxamine, ciprofloxacin It leads to a considerable slowing down of metabolism agomelatine , And accordingly to increase its concentration. Therefore, holding concurrent therapy with these drugs is contraindicated.
Also Rifampicin That is involved in the metabolism of agomelatine, is able to reduce its bioavailability. It can also occur in patients who abuse tobacco. With regard to the possible impact of agomelatine potential for other types of drugs, it is marginally or not fully understood.
Terms of sale
To purchase this drug requires a prescription.
Storage conditions
No special conditions are required, other than the child protector.
Shelf life
3 years.
Analogs of agomelatine
Despres
Gelarium Hypericum
Negrustin
Trittiko
Azafen
Neyroplant
The main analogue is Agomelatine . There are other analogs of agomelatine, for example - Adaptol and Paxil .
Alcohol
During treatment with agomelatine based, alcohol is contraindicated. The combined use of these funds causes increased inhibition of the function of the nervous system.
Reviews of agomelatine
This tool is often used in clinical practice. This marked his gentle but effective action. Some patients report that the treatment took place successfully without adverse events or reactions of intolerance.
However, there are reviews of agomelatine when disturbed patients: a sense of nausea . bouts of aggression , about tsutstvie appetite . These symptoms persisted not only in the initial stage, so we had to carry out a replacement drug.
In any case, the choice of antidepressant should be approached with particular responsibility and accept only funds that are assigned a specialist in a certain dosage.
Price agomelatine, where to buy
This drug can be bought in Moscow in almost any drugstore. The price of agomelatine varies from 1670 to 2060 rubles.
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