Description overdue on 07/18/2014
- Latin name: Rezalut Pro
- ATC code: A05S
- Active substance: Phospholipids (Phospholipids)
- Manufacturer: R.P.Scherer (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Rezalyuta
- Contraindications
- Side effects
- Rezalyut, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As the main component of which carries out the pharmacological effects of the drug are the rich and low-fat phospholipids . One capsule contains 300 mg of active ingredients. The prevailing active fraction is phosphatidylcholine Mass fraction of which is 76 percent of the total amount of phospholipids. The remaining 24 percent are divided between these polyunsaturated fatty acids as:
- Linoleic acid is an omega-3 - 62 per cent;
- linolenic acid, an omega-6 - 6 percent.
The composition is enriched with the following auxiliaries:
- gelatin;
- mono or diester of glycerol and edible fatty acids;
- 85 percent mono / dialkonat glycerol (C14-C18) - 120 mg;
- purified soybean oil - 138, 5 mg;
- Medium chain triglycerides - 40, 5 mg;
- alpha-tocopherol ( vitamin E ) - 1 mg.
Product form
The pharmacy drug Rezalyut Pro comes in the form of soft gelatin capsules oblong. The capsule itself is transparent, the inner content is a viscous liquid, golden-yellow or yellow-brown. Packed drug in blisters of 10 pieces each. Cardboard packaging can accommodate 1, 3 or 5 contour cell plate.
Pharmacological action
Rezalyut Pro - a pharmaceutical preparation, which belongs to the group hepatoprotectors That is, the primary effect of the drug is aimed at strengthening and enriching the cells of the liver, improved protective functions. The mechanism of action of the active components is repair of damaged cell membranes hepatocytes by endogenous phospholipids shortfall identical in chemical structure of substances.
During clinical studies have shown that the use of exogenous substances as building substrates intensifies the flow of reparative processes That is, the liver cells are recovered with greater speed Receipt of phospholipids from the outside is able to even suspend the damaging factors that can not be a voice for their use in the treatment of destructive diseases of the liver.
It should be noted that in addition to phospholipids the pharmaceutical preparation also comprises alpha-tocopherol in its composition. It a fat-soluble vitamin E The main pharmacological properties of which is antioxidant effect on the cell membrane. Due to its chemical structure tocopherol It binds free radical compound has saved thus cells from their destructive influence.
Pharmacodynamics and pharmacokinetics
Phosphatidylcholine It arrives in the gastrointestinal tract orally . Under the action of digestive enzymes before it breaks lyso-phosphatidylcholine And then is capable of absorbing. The walls of the intestine is re-synthesis of the phospholipid with the participation of their own systems. Further, there are two basic ways metabolism constituents of the pharmaceutical preparation. First of all, the active components to the liver, where the break down to such components as fatty acids . choline and glycerol-3-phosphate . Their excretion corresponds to the removal of phospholipids own.
Another part of the active substance, which is a great percentage of all received phospholipid in lymphatic channel arrives from the intestines and then detected and blood circulatory line . In plasma phosphoglycerides headed phosphatidylcholine firmly bonded to albumin and lipoproteins . In a few hours, these component parts are integrated into the body's own phospholipids, and that becomes the final point of the metabolism of the drug.
Indications Rezalyuta
- fatty degeneration liver of different origins;
- cirrhosis of the liver ;
- toxic or drug-induced glandular organ;
- chronic inflammatory diseases of the liver ( hepatitis );
- hypercholesterolemia (a drug used in case of failure, drug treatment measures, such as increasing physical activity, diet, or other measures to reduce body weight);
- psoriasis ;
- Radiation Syndrome - A symptom complex including cerebral, hematologic and gastrointestinal manifestations under the influence of ionizing radiation on the human body;
- unbalanced diet;
- neurodermatitis .
Contraindications
- hypersensitivity , Hereditary or acquired intolerance constituent components of the drug (or idiosyncrasy to the beans and soy foods, groundnuts);
- antiphospholipid syndrome - A multi-organ disease entities, which is characterized by the generation of immune antibodies to endogenous and exogenous phospholipids;
- in pediatric patients under 12 years old;
- periods of childbearing and breastfeeding .
Side effects
In the treatment according to the pharmaceutical preparation may experience the following adverse effects:
- On the side Digestive System : uncomfortable feeling in the stomach area, epigastric pain . diarrhea .
- Allergic reactions : rash or hives .
- Other: point petechial hemorrhage in the subcutaneous fatty tissue, intermenstrual bleeding women.
Rezalyut, instructions for use (method and dosage)
Capsules are provided for oral . Use should be before a meal without chewing and drinking plenty of water, so as not to damage the capsule. Digestive enzymes are essential for the proper metabolism of phospholipids are found only in the intestines because raskushennaya capsule loses all its pharmaceutical capabilities. Normal dosage of 6 capsules daily consumption - 2 pieces 3 times per day.
The course of treatment Rezalyut About appointed individually by the attending physician, as its duration can vary greatly depending on the therapeutic indications and metabolic properties of the organism. If within two weeks of active conservative therapy did not improve the patient's condition, the treatment is considered to be ineffective, and drug rehabilitation is terminated, in order to find a more powerful pharmaceuticals.
Overdose
At higher concentrations of the drug in the bloodstream can disorders of the gastrointestinal tract or increased side effects, however centralized research on drug overdose Rezalyut Pro was conducted.
Specific antagonist for the drug is not present, because the manifestation of symptoms of overdose used symptomatic drug treatment from the observed responses of the organism (actively used washing gastrointestinal salt solutions, enemas with various pharmaceuticals, artificial methods chelators and evacuation of the stomach).
Cooperation
Clinically significant interactions of the pharmaceutical preparation is quite small, since the main components of the drug components are part of the natural metabolism of the human body.
When used with Rezalyuta anti kumarinovyh (eg, Fenprokumona . Warfarin ) May increase the action of the latter, due to the effect on the liver. If the complex therapy is recommended regular inevitable diagnostic blood tests and adjust the dosage of drugs.
Terms of sale
The drug is in the free market, that is, in pharmacy can be purchased without a special form of the receptor.
Storage conditions
Store this medication out of reach of children at or above 25 degrees Celsius.
Shelf life
2 years.
Cautions
Was prescribed to patients with diabetes It should take into account that 1 capsule Rezalyut Pro contains less than 0, 1 BU (bread units).
The pharmaceutical formulation does not appear to have any effect on the patient's ability to carry out activities or work, necessarily requiring greater attention, coordination of movement and speed of psychomotor reactions, because during the course of conservative therapy is allowed to drive a car or other complex mechanisms.
Analogs Rezalyuta
Rezalyut Pro - a drug to which the components are a natural part of the human body metabolism, easy to reproduce in the laboratory because analogues of the drug is a fairly wide range of products.
Great demand Rezalyuta Russian counterparts, since their price is lower pharmacy costs a pretty penny. So conservative readjustment liver disease therapeutic effect of the pharmaceutical preparation can be replaced by any known means such as: Brentsiale . Livolayf . Lipoid . Fosfontsiale . Essentiale . Essliver .
Of the total number of pharmaceutical products it should be noted separately Essentiale . This is a drug that, thanks to extensive advertising, enjoys perhaps the most popular in the Russian and Ukrainian segment of the market to enhance the glandular body. However, most of the forums on the subject constantly ask the following questions.
Is it better or Essentiale Rezalyut?
The answer does not lie on the surface, to be a more detailed study of the pharmacokinetic ability of both drugs. Phospholipids have some Rezalyuta specificity of action As the main faction is running phosphatidylcholine . His influence aimed at restoration of cell membranes and improve the functioning of hepatocytes.
In Essenciale the main active ingredient is EPL-substance phospholipids Which is a highly purified and rich in polyunsaturated fatty acids fraction. This allows the pharmaceutical formulation act on intracellular structures (in particular mitochondria), and regulate the metabolic processes of oxidative phosphorylation. That is, the components in the physiological sense meet the needs of liver cells.
Summarizing all the above it can be concluded that Rezalyut acts more specifically, showing a maximum protective function against cell structure glandular organ. And wins respectively on such parameters Rezalyut. Indications for use, price and many other indicators - everything gives a few points ahead of Essentiale, of course, if the aim of therapeutic intervention is precisely the strengthening of the cellular structure of the liver, rather than improving the intracellular functioning hepatocytes.
Babies
In pediatric pharmaceutical formulation can be used to achieve 12 years.
With alcohol
Ethanol and its products are exchange damaging factors towards hepatocytes Because you must completely abandon the use of alcoholic beverages during the course of medical treatment, or the desired therapeutic effect of the pharmaceutical preparation and is reached (phospholipids Rezalyuta just cropped action of alcoholic beverages).
During pregnancy and lactation
Use of the drug Rezalyut About contraindicated during periods pregnancy , Lactation and breast-feeding As possible teratogenic the constituent components of the drug, but reliable clinical studies of this issue have been conducted.
Reviews on Rezalyut About
Reviews Rezalyute in the Pharmaceutical Forum characterize the drug on the positive side. People who have applied it, there is a marked improvement in health after a course of conservative therapy as a natural removal of toxic and harmful substances corresponds to normal again, thanks to the restoration of the physiology of the cellular structure of the liver.
Noticeable therapeutic effects and hypercholesterolemia. Rezalyut cleans macro and microcirculation of the products of fat metabolism, prevents the development of atherosclerosis of the blood vessels that nourish allows internal organs and systems with greater force. This is reflected in the improvement of the color of the skin, restoring a healthy appetite, normalization of all possible structures of the body and, of course, a good sense of self.
Doctors about Rezalyute confirm a strong therapeutic effect. In the opinion of qualified experts, the drug should be used as often as possible, because its components are a natural part of the metabolism of the human body, which is manifested in the meager amount of light currently treated side effects and adverse effects of treatment. Also, therapeutic hospital doctors emphasize that the possibility of an overdose of a pharmaceutical preparation is extremely small, which allows for conservative sanitation in large doses, and minimize the duration of therapy.
Price Rezalyut About where to buy
Price Rezalyuta in Ukraine is an exorbitant amount of 380 to 550 hryvnia, depending on the mesh pharmacies, where the drug is sold.
On the territory of the Russian Federation, the cost of the drug is somewhat more forgiving, and fluctuates within 400-600 rubles from. Of course, these prices are much more convenient to order pharmaceutical product on the Internet, as it can be bought already for 250-300 rubles.
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