Arutimol

Description overdue on 19.11.2011

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Antiglaucoma agent belongs to the group beta-blockers . Main, an active substance - timolol.   The drug reduces the synthesis of aqueous humor, strengthens its outflow, and thus a decrease in intraocular pressure. Effect of the drug does not affect the pupil diameter, the process accommodation , Visual acuity, does not distort the quality of night and color vision. Arutimol begins its action after 20 minutes after instillation, peak efficiency is recorded in 2 hours, the effect lasts for hours. It is produced in the form of eye drops, eye gel.

Indications:

Arutimol prescribed for elevated intraocular pressure: secondary (afakicheskaya, uveal, posttraumatic) glaucoma, open-angle glaucoma. In addition, used to treat angle-closure glaucoma (with miotikami) the ineffectiveness of therapeutic interventions in congenital glaucoma (acute increase in intraocular pressure, buphthalmos ).

Contraindications:

Arutimol not used in degenerative processes in the cornea, allergic to timolol. Be wary appoint patients with bronchial asthma, COPD (severe), sinus bradycardia   (Heart rate less than 55), atrioventricular block grade 2-3, decompensated heart failure, atrophic rhinitis, low blood pressure, severe cerebrovascular disease, pulmonary disease, hypoglycemia, diabetes . myasthenia . thyrotoxicosis . Arutimol not indicated during pregnancy.

Side effect:

Before the drug can Arutimol local reactions: violation of tearing, conjunctival hyperemia Edema of the corneal epithelium,   photophobia , Itchy eyes, burning, blepharitis . keratitis Hyperemia century, keratopathy point (reduction of corneal transparency) ptosis Rarely observed diplopia . Among systemic reactions observed paresthesia , Nasal congestion, rhinitis, drop in blood pressure, bradycardia, collapse, atrioventricular block, decreased myocardial contractility. In the presence of heart failure marked worsening of its manifestations, marked hallucinations . myasthenia , Depression, dizziness, drowsiness, reduced potency, bronchospasm , Shortness of breath, pulmonary failure, chest pain, vomiting, dyspepsia, ringing in the ears, decreased psychomotor speed reactions.

Mode of application:

For children of 10 years and Adults: 1 drop into the conjunctival sac twice a day (0.25% solution). Supportive dosage for normalization of intraocular pressure - 1 time per day, 1 drop 0, 25% solution.
Arutimol infants and children younger than 10 liters: 1 drop twice a day 0, 25% solution.

Overdose:

Characterized obscherezorbtivnymi effects ( nausea , Bronchospasm, bradycardia, arrhythmia, dizziness). First aid: rinsing with a solution of NaCl (0.9%) or water.

Special instructions:

It is recommended to give up driving in the dark, and activities requiring adaptation to low light. Prolonged therapy with Arutimol reduces the efficiency of timolol. Every 6 months, you must check the integrity of the cornea, slezovydelenie, the value of the visual field. Monthly measure the level of intraocular pressure. During treatment it is necessary to abandon the soft contact lenses (since settling them preservative formulation). Hard lenses may be worn in 15 minutes after administration Arutimola.

Drug Interactions:

System beta-blockers, pilocarpine , Epinephrine enhances the effectiveness of timolol. It prohibits the simultaneous reception tranquilizers   (antianxiety drugs) and neuroleptics   (antipsychotic drugs). Arutimol enhances the action of general anesthetics and muscle relaxants . Not recommended intravenous diltiazem . verapamil   (lower blood pressure, develop bradycardia, depress AV conduction). Ethanol in combination with timolol sharply lowers blood pressure. Be wary at the same time used oral hypoglycemic drugs,   insulin , Blockers, corticosteroids, psychoactive drugs.