Clarithromycin

Description overdue on 07.02.2012

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Macrolide antibiotics . Drug action is directed to a violation of protein synthesis in the bacterial cell. Clarithromycin affects the intracellular and extracellular pathogens. The lowest activity is shown against Mycobacterium tuberculosis . It is produced in the form of capsules, granules, lyophilisate, powder, in pellet form.

Indications and contraindications:

Clarithromycin effectively is applied at bacterial infections. Respiratory system : SARS . bronchitis . pneumonia . sinusitis . pharyngitis . laryngitis . tonsillitis . Skin : Wound infection, impetigo , Abrasions, folliculitis . The drug is prescribed for chlamydia , Mycobacteriosis, ulcerative lesions of the digestive tract, otitis media. Clarithromycin is contraindicated in porphyria , Intolerance to the components, breastfeeding, pregnancy, concomitant use of terfenadine, pimozide, cisapride. In the pathology of the renal system used with caution, in small doses.

Side effects and overdose:

Senses : dysgeusia   (dysgeusia), short-term hearing loss. Nervous system : Confusion, depersonalization , Psychosis, disorientation . hallucinations , Dreadful dreamings, insomnia, anxiety, of vertigo and headaches. Digestive system : pseudomembranous enterocolitis , Cholestatic jaundice, increased liver enzymes, glossitis, stomatitis, diarrhea, gastralgia, vomiting, nausea, dyspepsia. Perhaps the development of thrombocytopenia , Allergy,   anaphylactic reactions Forming microbial resistance. If overdose is marked confusion, headaches, disturbances in the digestive tract. Timely gastric lavage. No antidote. Therapy posimptomnaya.

Mode of application:

Vzsrolym prescribe the drug clarithromycin twice a day for 250-500 mg. The course of antibiotic treatment is 1-2 weeks. Treatment of severe disease includes, besides receiving a tablet form of the drug has antibiotic intravenous - 500 mg per day, the rate of up to 5 days. Then move on to monotopnuyu, tableted therapy, the overall course of treatment - 10 days. In severe infections, sinusitis take on 0, 5 - 1 gram twice daily for 6 months. For children Clarithromycin is produced in the form of suspensions: 7, 5 mg / kg twice daily. When expressed pathology the renal system dose antibiotic reduce in 2-4 times.

Special instructions:

The presence of chronic liver disease requires regular monitoring of blood parameters. When concomitantly with drugs whose metabolism takes place in the liver, Clarithromycin administered with caution. Simultaneous treatment with indirect anticoagulants , Warfarin requires control prothrombin index . In the pathology of the cardiovascular system is unacceptable concurrent use of cisapride, astemizole and terfenadine.

Drug Interactions:

Application of of medicinal funds, metaboliziruthan with the help of P450   ( digoxin Lovastatin, phenytoin, disopyramide, rifabutin , Cyclosporine, midazolam, triazolam, terfenadine, cisapride, astemizole, theophylline, carbamazepine , Indirect anticoagulants and others) is not allowed in the treatment of clarithromycin. The drug reduces the absorption of zidovudine. It noted the development of cross-resistance between clindamycin,   lincomycin   and clarithromycin.