Description overdue on 08/12/2014
- Latin name: Sedalgin Plus
- ATC code: N02BB72
- Active substance: Metamizole + Caffeine + Thiamine (Metamizole sodium + Caffeine + Thiamine)
- Manufacturer: Balkanpharma-Dupnitza (Bulgaria)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition Sedalgin Plus
The tablet contains 500 mg metamizole Na 50 mg caffeine and 38 to 75 mg thiamine hydrochloride . The composition Sedalgin Plus includes additional components: colloidal silica 2, 5 mg, 11 mg wheat starch, microcrystalline cellulose 45, 75 mg, 12 mg of talc, gelatin 4 mg, 6 mg Mg stearate.
Product form
Sedalgin plus is available in tablet form. The flat, round tablet white color with bilateral facet packed in blisters of 10 pieces. Each carton box 1 or 2 blisters.
Pharmacological action
The drug has anti-inflammatory, analgesic and antipyretic activities.
Metamizol Na It has a weakly expressed anti-inflammatory action, has analgesic effect. The mechanism of action is based on the ability of pyrazolone derivatives inhibit the process of synthesizing prostaglandins by inhibiting cyclooxygenase.
Caffeine It stimulates the nervous system by activating the vasomotor center, the cortex and the respiratory center. The active ingredient reduces the severity of fatigue and sleepiness, increases physical and mental performance. Caffeine enhances the therapeutic effect of non-narcotic analgesics, increasing their bioavailability and increasing permeability gistogematicheskih barriers.
Thiamine It helps to keep the neuro-reflex conductivity, improves metabolism. Also known as vitamin IN 1.
Pharmacodynamics and pharmacokinetics
Performance depends on the components that are part of the drug.
Metamizol Na completely absorbed from the digestive tract in a relatively short period of time. Maximum concentrations recorded through 1-1, 5:00 after taking. The active ingredient is bound to plasma proteins and is metabolized in the liver system. FROM bile Pin 10 Metabolites%, 90% - through the renal system. The half-life is approximately 10 hours.
Caffeine is almost completely absorbed from the digestive tract. The maximum level of active ingredient is observed after 30-40 minutes. Caffeine is able to penetrate into breast milk, pass through blood-brain barrier . The metabolites excreted unchanged via the renal system.
In thiamine absorption after oral administration, and it achieves high numbers carried in the lumen of the small intestine. Digestive enzymes Thiamine Hydrochloride release from the bound state to the suction. The level of thiamine in blood is quite low. The plasma can be detected only free thiamine and its phosphate esters are blood cells: leukocytes and erythrocytes . 40% of thiamine can be detected in the internal organs, and more than 50% - striated muscle. Phosphorylation process is carried out in the liver tissue. Tiamindifosfata has co-enzyme activity, and is the most active phosphoric ester. It accumulates in the kidneys, heart muscle, liver tissue, spleen, brain. Displayed through the renal system, part - through the intestines.
Indications
From what is prescribed Sedalgin Plus? Mainly for relief pain when:
- dysmenorrhea ;
- neuralgia ;
- migraine ;
- polyneuropathy;
- pleksite;
- inflammatory diseases of the locomotor system;
- degenerative diseases of muscle tissue;
- toothache;
- radicular syndrome;
- after surgery.
Contraindications
- thrombocytopenia;
- anemia;
- leukopenia;
- Individual hypersensitivity ;
- expressed atherosclerotic changes ;
- hepatic porphyria;
- breast-feeding ;
- suspected acute surgical pathology;
- NSAID intolerance;
- peptic gastrointestinal pathology ;
- sleep disorders;
- vynashivanie pregnancy ;
- pathological anxiety;
- liver pathology system;
- bronchial asthma ;
- glaucoma ;
- simultaneous treatment of MAO inhibitors;
- hypertonic disease ;
- kidney disease.
With caution is prescribed for combined tool:
- achalasia ;
- Coronary artery disease;
- Arrhythmia ;
- pyloric stenosis of the digestive system;
- hyperplastic changes in the tissues of the prostate;
- bronchospastic reactions;
- hyperthyroidism ;
- heart failure (stagnant);
- reception of medicines which depress the nervous system;
- gastroesophageal reflux .
Side effects
Hematopoietic system:
- Purpura;
- leukopenia ;
- thrombocytopenia (decrease in the number Platelet );
- hemolytic anemia;
- agranulocytosis .
The digestive tract:
- jaundice ;
- vomiting ;
- violation of appetite;
- cholestasis;
- nausea.
Nervous system:
- irritability;
- dizziness ;
- insomnia .
Cardiovascular system:
- arrhythmias;
- feeling palpitations.
Allergic responses:
- redness;
- itching ;
- anaphylactic shock ;
- angioedema ;
- bronchospasm.
In case of other negative reactions the patient should see a doctor, stop taking Sedalgin Plus.
Instructions for use (method and dosage)
The drug is taken orally. Tablets should be washed down with water. When pain syndrome appoint one tablet three times a day. With the ineffectiveness of the number of tablets can be increased up to 6 units per day. In pediatric designate ½ tablets three times a day but not more than four pieces.
Overdose
Manifested rashes on the skin. Less registered tremor of the extremities , Anaphylactic shock, hallucinations , Clinical picture similar to Meniere's disease. A significant excess of recommended doses may result in loss of consciousness, serious changes of the heart, nervous system and blood. Requires Cleaning the stomach and intestines from the remnants of the medication, appointment sorbents Holding posindromnogo treatment. Specific antidote Plus Sedalgin to be developed. When the diagnosis of hemorrhagic gastritis conduct gastric lavage with cold sodium chloride NA (0, 9%) and antacid administered. If necessary, carried oxygenation, lung ventilation is maintained. At seizures introduced Phenytoin . Diazepam intravenously. It is important to maintain the level of liquids and salts at the appropriate level.
Cooperation
Metamizole is able to enhance the toxic effects of other medicines. Medications that increase toxicity Sedalgin Plus and break metabolism components:
- Allopurinol ;
- antidepressants (tricyclic);
- contraceptives in oral form .
Inductors microsomal enzymes (Phenylbutazone, barbiturates) weaken the effect of the drug. Metamizole is able to reduce levels of cyclosporine in the blood. Analgesic effect Sedalgin Plus is enhanced when taking tranquilizers and other sedatives.
Terms of sale
OTC medicines.
Storage conditions
Producer limited temperature storage - up to 25 degrees. Limit children's access to blister.
Shelf life
2 years.
Cautions
Overdose symptoms may also occur when the patient excessive use of foods high in caffeine (coffee, tea). In diseases of the kidneys and liver system, it recommended further examination. The risk of developing allergic response higher in patients hay fever , Bronchial asthma (atopic form). It is unacceptable to take alcoholic beverages in conjunction with taking medication.
Analogs
Revalgin
Andipal
Reopirin
Analgene
Tempalgin
Pentalgin
- Benalgin;
- Baralgin;
- Baralgetas;
- Pentalgin.
Reviews Sedalgin Plus
Doctors often prescribe medication as part of pain therapy. On the forums, patients leave their reviews about Sedalgin Plus, pointing to the good tolerability of tablets and high efficacy in relieving pain.
Price Sedalgin Plus, where to buy
Packing cost depends on the amount of pills and sales area. Price Sedalgin Plus in Russia is 90-120 rubles for 10 tablets, and 150-200 rubles per 20 tablets.
No comments:
Post a Comment