Pimafukort

Description overdue on 06/17/2014

• Latin name: Pimafucort
• ATC code: D07CA01
• Active substance: Hydrocortisone, natamycin, neomycin (Hydrocortisone, Natamycin, Neomycin)
• Manufacturer: Astellas Pharma Europe B.V. (Netherlands)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Ointment Pimafukort, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The amount of biologically active components absolutely does not change depending on the form of a pharmaceutical preparation. As in the cream and ointment stored in the basic relation:

• natamycin - 10 mg;
• Neomycin sulfate   - 3500 units;
• micronized hydrocortisone   - 10 mg.

What really distinguishes the variations of dosage forms to a large extent, this excipients are many more in the cream, which suggests a more selective effect of the drug. So harmonious background active component creates:

• F-emulsifier - 115 mg;
• tsetiol V 150;
• tsetilefirny wax - 60 mg;
• sorbitan stearate - 30 mg;
• macrogol stearate 100 - 20 mg;
• sodium citrate   - 14 mg;
• methyl parahydroxybenzoate - 2 mg;
• Propyl - 0.5 mg;
• Purified Water - up to 1000 mg.

Excipient ointments - it only ointment base in an amount of 976.5 mg (mass fraction contains 95 percent paraffin wax and 5 percent PE).

Product form

On the shelves of pharmacy drug Pimafukort can be found in two varieties:

• white with a yellow tinge cream in aluminum or plastic tubes of 15 grams each. In a cardboard box - 1 tube.
• ointment white to yellow color, 15 grams of a plastic or aluminum tubes (1 tube per pack).

Pharmacological action

Pimafukort - an integrated pharmaceutical formulation, for both drug has antibacterial, anti-   and antifungal effects . Due to the presence of such active components as neomycin sulfate , Which has antibiotic properties, the drug is able to help, even in cases of infection by gram-negative microorganisms, for example,   Proteus, Klebsiella   or Escherichia . Gram-positive bacteria such as staphylo-   or enterococci Also respond well to treatment Pimafukortom.

Natamycin, another active substance preparation is a pharmaceutical group macrolides , Synthetic polyene subgroup, that is, as neomycin, an antibiotic in nature. However Natamycin more active against yeast and Yeast   and dermatophytes. With this component, you can win a family of microorganisms such as Candida . Aspergilus . Trichophyton   and others. Active Natamycin and against protozoa, for example, Trichomonas and Fusari .

Hydrocortisone   completes the three active components of the preparation. This hormone, because the spectrum of therapeutic effects of its most wide:

• reduces the sensation itching ;
• reduces symptoms of inflammation in the pathology of the skin (especially hyperthermia and hyperemia);
• inhibits hypersensitivity reactions;
• suppresses the active processes alteration . exudation and proliferation ;
• It prevents activation phospholipase A2 Thus suspending prostaglandin synthesis and secretion of macrophage chemotactic factor;
• inhibits the activity hyaluronidase ;
• blocks the synthesis and release of sensitized bazo0 and eosinophils;
• inhibit various stages of the local immune process, without causing mitostaticheskogo action .

Therefore, the question " Pimafukort - hormonal or not? "Should not be, because the drug actually contains the active micronized Hydrocortisone Which is the activity of endogenous adrenal hormones. However, counter stereotypical and unfounded rumors and fears, namely hormone-based and creates a diversity of therapeutic effect of the pharmaceutical preparation, which is observed during the conservative treatment of various diseases.

Pharmacodynamics and pharmacokinetics

The pharmaceutical preparation is low adsorptive threshold on intact skin, that is, almost no active ingredients are absorbed into the body if the order does not require the state thereof (bioavailability of hydrocortisone is about 1-3 per cent). However, when applied to a wound defects (scratches, abrasions, ulcers, etc.) or mucosal ability Pimafukorta absorbed increases several times. So eczematous damage absorb 2 times better than the undamaged areas and destruction of an infectious nature - in 4 times.

Indications

From what helps salve Pimafukort listed in the following list:

• Skin fungal infections   - A fungal disease etiology (cause is invasion of fungal microorganisms ) That affect the skin of the human body;
• surface Medicine If the infectious agent is sensitive to existing components of the drug;
• pyoderma - Purulent skin lesions as a result of the invasion of pathological microorganisms;
• complication secondary fungal and / or bacterial infection (e.g. candidiasis );
• otomycosis - Inflammation of the external auditory canal and the ear of the defeat of parasitic fungi that vegetate in the thickness of the skin.

Contraindications

Do not include cream or ointment Pimafukort in the course of medical treatment, if any:

• individual hypersensitivity or intolerance to the components of a pharmaceutical preparation;
• cutaneous Syphilis ;
• Rosacea (people just " rosacea ") - A chronic disease affecting skin due angionevroticheskih disorders and recurrent;
• ichthyosis   (or diffuse keratoma ) - Congenital abnormality reinforced keratinization of the dermis and its appendages;
• anogenital itching   - Unpleasant sensations of discomfort in the genital area and the anus;
• tuberculosis   mainly affecting the skin (extrapulmonary disease);
• acne (ordinary acne ) Regardless of the etiological factors;
• skin reactions after the injection;
• skin diseases Oncology origin;
• viral lesions cover;
• side effects from the pharmaceutical preparations of corticosteroids - perioral dermatitis or striae (strip atrophoderma - stretching the skin in the form of white or purple bands) on the body surface;
• increased fragility of blood vessels in the skin, especially in the treatment site preparation.

Side effects

First of all adverse reactions occur very rarely , About 0.1% cases of conservative treatment cream or ointment Pimafukortom may experience the following side effects:

• withdrawal symptoms when stopped suddenly therapeutic course;
• appearance striae If the drug is used in place of permanent skin folds;
• perioral dermatitis ;
• atrophy or thinning of the skin;
• telangiectasia ("Spider veins") or even purpura ;
• hypertrichosis - Excessive hair growth on the non-core areas of the skin, inappropriate sex and age;
• hypersensitivity reactions in relation to the drug - itching . burning . congestive redness . local dry ;
• Increased intraocular pressure and increased risk of Cataract When using liniments face.

Ointment Pimafukort, instructions for use (method and dosage)

The drug is administered in various forms of release for the treatment of various pathologies. So sharp Medicine advantageously treated with cream Pimafukorta and chronic, sluggish pathology treated with the ointment. Especially effective ointment when applied occlusive dressing   or skin became dry, they were lihenifikatsii (secondary morphological elements of a skin rash as a local thickening, pigmentation and strengthening of the figure).

Applied pharmaceutical preparation is not affected area 2-4 times a day, depending on the extent of the prevalence and severity of the pathological process. Instructions for use Pimafukorta states that the duration of treatment establishes a dermatologist, it usually lasts from 2 weeks to 1 month. It is not recommended to continue treatment for more than 14 days in young children because their skin is still in the process of formation and use of pharmaceutical drug can cause side effects much more quickly than adults.

Overdose

Confirmed information about drug overdose or adverse effects of increased concentrations of the ointment there, but there is a theoretical possibility Valium actions That is damaging the hearing aid as a result of conservative treatment. This probability appears if the therapy otomycosis   Pimafukorta and applying into the ear canal has a crack or perforation in the eardrum. This will open the possibility of exposure to neomycin for the middle ear, which can lead to its damage and partial or complete hearing loss.

Cooperation

Typically, notes   Cross-resistance   with prior treatment such antibiotics , as Kanamycin . Paromomycin . Neomycin . Gentamicin   and other drugs macrolide.

Terms of sale

The pharmaceutical preparation in the pharmacy dispensed only by prescription.

Storage conditions

Pimafukort should be stored in a dry place out of reach of young children and middle-aged, at a temperature no higher than 25 degrees Celsius.

Shelf life

3 years for a cream and ointment for 5 years

Cautions

During use, the drug should be aware of the possibility of adrenocortical suppression   - State, when the vast production of corticosteroids by the adrenal glands, as already circulating in the systemic circulation gidroksikortizon . In this case, you should immediately cease to use Pimafukorta and contact a qualified technician for help.

Active ingredients Pimafukorta (neomycin, Natamycin) are antibiotics So when carrying out medical treatment should follow the general rules Antibiotic :

• Clearly withstand recommendations for duration of medication, so that micro-organisms do not develop resistance certain groups of pharmacological agents.
• Immaculately follow the dosing regimen.
• Self did not stop the course of conservative treatment, unless the reason is not side effects or adverse reactions.

Analogs Pimafukorta

Match code ATC 4th level:

• Gioksizon

Currently, the pharmaceutical market there is no identical counterparts Pimafukort ointment, but there are a combination of drugs , Composed of glucocorticosteroids . antifungal agents and antibiotics in different variations. This is the pharmacological analogs Pimafukorta, because these drugs have similar therapeutic effects and are used to treat similar pathologies:

• Dexa-Gentamicin   ( Gentamicin   and Dexamethasone );
• Oksikort   ( Hydrocortisone and Oxytetracycline );
• Flutsinar   ( Neomycin and Fluocinolone ).

As a rule, the price is different from the analog value Pimafukorta, since such drugs usually do not have a pronounced anti-fungal effect. For example, the price is about 50 Oksikort hryvnia in Ukraine, but the online pharmacies drugs usually cost less.

Babies

Use of the drug for young children (especially for infants   and Newborn ) Is absolutely contraindicated, because the skin in such a young child during the development of his body still in the process of formation, that is, they are gradually adapting to a new and unfamiliar environment. Because undesired reactions or side effects   Treatment can be manifested much earlier, which is fraught with serious consequences, which are primarily cosmetic.

During pregnancy and lactation

When the Pimafukorta in the scheme of conservative treatment of pregnant or nursing women should be aware of the possible Valium actions   Neomycin on developing the baby and mother. It is also not recommended to apply the cream or ointment under occlusive dressing or used drugs for a long time, is not it, you can skip the first occurrence of side effects or adverse reactions of the therapeutic action of the drug.

Reviews Pimafukorte

Reviews Pimafukorte filled with positive emotions. Often there are pleasant impressions of mothers of newborns who are using the cream for the children to get rid of the rash first baby, as the drug has few side effects along with the breadth of therapeutic action.

Often, however, there are also reviews about the futility of using ointments for a long period of time. These patients tend to ignore the recommendations of the doctor and self Pimafukort changing to a cheaper analog of what to do in any case is impossible, because a dermatologist familiar with the pathology of the skin much better.

Also known clinical cases when after applying the ointment case of aggravation of the underlying disease. On the probability of such an outcome notify information insert in carton drug. If the disease has passed the stage of progression should immediately refuse further admission Pimafukorta and turn to the person skilled in the near future.

In the review, the drug frequently asked questions that best cream or ointment, for which there is no single answer, because there are differences in the indications for use of various pharmaceutical forms, excipients, which create the necessary background for the full effect of the active components. Thus the cream effectively treats acute disorders of the skin, while the ointment is better to treat a chronic relapsing disease.

Price Pimafukorta where to buy

The price of the cream Pimafukort, and indeed in the ointment, in the Russian Federation is about 400 rubles. In Ukraine, the price fluctuates Pimafukort ointment in 130 hryvnia, depending on the selected network pharmacies. More profitable to order medication online pharmacies, where the price of medicinal products is several times lower.

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