Diabeton

Description overdue on 26.10.2011

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Main, an active substance - gliclazide . Hypoglycemic agents of the sulfonylureas of the second generation. Gliclazide is a sulfonylurea. It contains azobitsiklooktanovoe ring, which significantly distinguishes the mechanism of action of the biguanide antidiabetic and sulfonamides. The drug also has hemovascular . metabolic   and antioxidant   action. Under the influence of Diabeton reduced blood glucose concentration (blagodaryausilennoy special development of insulin from the beta cells of the pancreas). Patients with diabetes   the second type of drug returns early peak generation   insulin And raise the next phase insulinosekretsii. Increased insulin concentration occurs before a meal or glucose challenge. The antioxidant action and hemovascular drugs reduce the risk of complications of diabetes. Diabeton prevents mikrotrombozov   due to the partial inhibition of aggregation, platelet adhesion, reducing the number of markers of platelet activation. The preparation increases the activity tPa acts on the fibrinolytic activity of endothelial vessel wall. Glikazida antioxidant effect is achieved by reducing the concentration lipid peroxide   in the blood plasma, increased activity dismutase erythrocyte plasma thiols, increased total antioxidant capacity. Gliclazide is metabolised in the liver.

Indications:

Type II diabetes (the ineffectiveness of diet programs and weight loss).

Contraindications:

Diabetic ketoacidosis , Diabetes first type, severe pathology renal and hepatic systems, diabetic precoma, coma Pregnancy. Be wary appoint elderly Diabeton after extensive burns. Do not use in pediatrics.

Side effect:

With inadequate diet, abuse dosage regimen notes hypoglycemia , Hunger, fatigue, headache, sweating, palpitations heartbeat , Insomnia, anxiety , Aggression, inattention, blurred vision,   paresis . tremor , Depression, inattention, aphasia , Sensory impairments, delirium, hypersomnia, convulsions . GIT: dyspepsia, cholestatic jaundice, loss of appetite, increased liver enzymes. Bodies of hematopoiesis: suppression of bone marrow hematopoiesis function. Allergies.

Mode of application:

Diabeton taken orally during meals. The initial dose - 80 mg per day, average - 160-320 mg. The dosage is selected individually. Diabeton dose depends on the severity of disease, age, blood sugar levels.

Overdose:

Disturbances of consciousness, hypoglycemia, coma . It is necessary to introduce a 40% hypertonic dextrose, sugar ingest 2 mg glucagon . Spending control blood sugar every 15 minutes. Take food rich in carbohydrates (digestible). If swelling of the brain appointed dexamethasone Mannitol.

Special instructions:

Decompensated diabetes, surgery is necessary to consider taking insulin. At the use of ethanol increases the risk of hypoglycemia. When emotional, physical overexertion is necessary to adjust the dose Diabeton. The elderly, patients with pituitary-adrenal insufficiency are especially sensitive to hypoglycemic drugs. It slows down the speed of psychomotor reactions.

Drug Interactions:

Blockers H2-histamine receptors, ACE inhibitors, NSAIDs, fibrates, antifungals, coumarin anticoagulants, MAO inhibitors, anabolic steroids, sulfonamides, biguanides, cyclophosphamide, pentoxifylline Theophylline, tetracycline , Reserpine, disopyramide, insulin,   ethanol . allopurinol   Diabeton enhance the effect.

GCS barbiturates , Antiepileptic, adrenostimulyatorov, BCCI, thiazide diuretics, triamterene, Furosemide . baclofen , Diazoxide, asparaginase, triamterene, morphine, isoniazid Terbutaline, ritodrine, glucagon, salbutamol, rifampicin, Estrogens Chlorpromazine, a nicotinic acid   weaken the effect of the drug.