Seduksen

Description overdue on 11.05.2012

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Anxiolytics . Base material diazepam . The drug has anticonvulsant, sedative-hypnotic, central muscle relaxant effects. The active ingredient is a derivative of benzodiazepine. The principle is based on the effects of stimulation of benzodiazepine receptors, which are located in the reticular allosteric Central Pharmacy in the brain stem. The anxiolytic effect on the impact caused by limbic system   (amygdala). Seduxen reduces the severity of anxiety, emotional stress, anxiety, fear. Due to non-specific effects on the nucleus in the thalamus, reticular pharmacy   brainstem manifests sedative effect, reduces the severity of neurological symptoms (fear, anxiety). Hypnotic effect   It manifested through inhibition of reticular cells pharmacy in the brain stem. Seduxen suppresses epileptogenic activity Without having to remove the excitement from the hearth. With increasing presynaptic inhibition is realized anticonvulsant effect. Diazepam can lead to expansion of the coronary arteries and the fall in blood pressure. Seduxen increases the pain threshold, decreases gastric acid secretion at night suppresses paroxysms . Efficacy registered on 2-7 days of use. In chronic alcoholism, drug withdrawal syndrome, reduces the severity of the tremor, agitation, negativism, hallucinations, delirium tremens . When arrhythmias, cardialgia, paresthesia effect is recorded on the seventh day of application. Seduxen produced in the form of pills, a solution, tablet.

Indications:

Seduxen prescribed for insomnia, dysphoria , Anxiety, spastic conditions caused by spinal cord injuries and brain, skeletal muscle in spasm, bursitis, myositis, chronic progressive polyarthritis , Arthritis, rheumatoid pelvispondiloartrite, vertebral syndrome , Headaches, stress, angina. Diazepam is prescribed for transient reactive states, anxiety, tremor, agitation, tension, withdrawal syndrome . Seduxen prescribed for the complex treatment of peptic ulcer disease, hypertension, menstrual disorders, psychosomatic disorders in gynecology and obstetrics, with menopausal disorders, status epilepticus,   gestoze , Meniere's disease, eczema. The drug is prescribed for medicinal poisoning, before surgery, general anesthesia, endoscopic manipulation. Parenteral drug prescribed for motor stimulation in psychiatric and neurological practice, myocardial infarction. Seduxen shown in premature detachment of the placenta, to facilitate delivery, with premature birth For the relief of seizures, with paranoid-hallucinatory states .

Contraindications:

Seduxen not prescribe medication for acute intoxication, acute alcohol intoxication, shock, coma when, diazepam intolerance, severe COPD, myasthenia gravis, when the form-closure glaucoma, absence seizures, acute respiratory distress syndrome Lennox-Gastaut, pregnancy, breastfeeding. With epilepsy   a history of spinal ataxia, seizures, cerebral ataxia, organic brain disease, the elderly, the propensity to abuse drugs, with hypothermia and Sleep apnea   Seduxen used with caution after specialist consultation.

Side effect:

Nervous system:   in elderly patients in the early stages of treatment can be fatigue, dizziness, increased drowsiness, unsteadiness when walking, disorientation , Ataxia, impaired concentration, ecmnesia , Mental retardation, motor reactions, depression, migraine, tremor, euphoria , Catalepsy, weakness, extrapyramidal dystonic reactions, confusion, myasthenia gravis, ataxophemia , Hyporeflexia, paradoxical reactions (suicidal thoughts, fear, aggression, muscle spasms, agitation, hallucinations, irritability). The digestive tract:   nausea, stomachalgia . heartburn , Dry mouth, hiccough . hyperptyalism , Increased levels of liver enzymes, liver malfunctions of the system, disturbances of appetite. Bodies of blood:   anemia, thrombocytopenia , Agranulocytosis, neutropenia, pyrexia. Urogenital:   decreased libido, disturbances in the renal system, dysmenorrhea , Urinary retention, urinary incontinence . Seduxen can trigger an allergic response. The drug has teratogenic effects on the fetus , Depresses the central nervous system, inhibits the sucking reflex, disrupts the respiratory system. Other local side effects recorded venous thrombosis, phlebitis, redness and swelling at the injection site. Seduxen can lead to drug dependence, diplopia, respiratory dysfunction, bulimia. In a dramatic admission of diazepam registered syndrome "cancel" , There is anxiety, headache, irritability, anxiety, sleep disorders, anxiety, agitation, depersonalization, dysphoria, depression, sweating, paraesthesia, hyperacusis, perception disorders, tremor, vomiting, nausea, acute psychosis, hallucinations, tachycardia , Convulsions. Application in term, preterm infants in obstetrics: hypothermia, dyspnea, hypotension, muscle.

Overdose:

Manifested confusion, excessive sleepiness, decreased reflexes, paradoxical excitation, deep sleep, stun, areflexia , Nystagmus, bradycardia, apnea, tremor, dysarthria, drop in blood pressure, depression of the heart and respiratory system, coma, collapse, coma. Timely gastric lavage, the appointment of enterosorbents, forced diuresis. Posindromnaya therapy is aimed at stabilizing blood pressure, maintenance of the respiratory system, mechanical ventilation. Specific antagonist is flumazenil Which is administered in a hospital. Appointment hemodialysis considered ineffective.

Mode of application:

Seduxen administered rectally, intravenously, intramuscularly, orally. The dosage depends on the patient's sensitivity to a drug, the clinical picture of the disease, the patient's condition. For the anxiolytic effects of diazepam administered 2-4 times a day for 2, 5-10 mg. In psychiatric practice, hypochondriacal, hysterical, disforiynyh states, psychosis drug prescribed 2-3 times daily for 5-10 mg. In some cases, the dosage is increased to 60 mg per day. When the drug abstinence syndrome in the first day taken 3-4 times for 10 mg dose is then reduced by assigning the drug 3-4 times 5 mg. In practice, neurological degenerative diseases, spastic states of central origin: 2-3 times 5-10mg. Comprehensive treatment of myocardial infarction: 10 mg intramuscularly and then orally 1-3 times 5-10mg. For sedation if defibrillation : Slow intravenous injection is administered in divided doses of 10-30 mg.

Special instructions:

Intravenous infusion seduksena carried out slowly, preferably in a large vein, per milliliter (corresponding to 5 mg) - 1 minute. Unacceptable holding incessantly intravenous infusion because of the risk of drug adsorption, precipitation. During treatment requires a complete rejection of alcoholic beverages. In severe liver disease, renal system requires regular monitoring of the state of the blood, liver enzymes. Application of high dose for a long time causes medication dependency . Treatment should be terminated gradually to prevent the syndrome of "cancellation", which manifests confusion, anxiety, headaches, tension myalgia, hyperacusis, depersonalization, tactile hypersensitivity, photophobia, seizures,   hallucinations , Paresthesias in extremities. When suicidal thoughts, anxiety, muscle cramps, agitation, aggression therapy Seduxenum gradually stop. Pregnant women are prescribed diazepam only in rare cases, life-saving. Seduxen affects memory, attention, complex contracts.

Drug Interactions:

Seduxen potentiate the inhibitory effect of neuroleptics, ethanol, antidepressants, sedatives, narcotic analgesics, muscle relaxants, drugs for anesthesia on the central nervous system. Erythromycin, cimetidine, disulfiram, oral contraceptives, valproic acid, propranolol . ketoconazole . metoprolol , Propoxyphene, fluoxetine . isoniazid   and other inhibitors of microsomal oxidation increase the effect of the drug, as well as prolong its half-life. The opposite effect is recorded while the appointment inducers of microsomal enzymes . Antacids reduce the absorption rate seduksena, but do not affect the completeness of absorption. Narcotic analgesics can lead to psychological dependence, strengthen euphoria. In the appointment of antihypertensive medicines marked decrease in blood pressure. Clozapine increases respiratory depression. In patients with Parkinson's disease seduksen reduces the effectiveness of the drug L-dopa. In the appointment of omeprazole marked lengthening the time excretion of diazepam. Analeptics, MAO inhibitors, stimulants significantly reduce the activity of diazepam. Seduxen able to increase the toxicity of zidovudine. Rifampicin   reduces the concentration of drug in the blood, increases its excretion from the body. Low dose theophylline diminish, distort sedation. Never mix the drug with the other drugs in the same syringe.