Klaforan

Description overdue on 08/25/2014

• Latin name: Claforan
• ATC code: J01DD01
• Active substance: Cefotaxime (Cefotaxime)
• Manufacturer: Aventis Pharma (UK)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use klaforan (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The preparation contains cefotaxime .

Product form

The drug is sold as a powder for solution for injection, it is in bottles of one piece in the package.

Pharmacological action

The drug has a bactericidal and antibacterial action.

Pharmacodynamics and pharmacokinetics

Klaforan - is antibiotic   third generation. It is known for a wide spectrum of antimicrobial action. It is effective against many Gram-negative organisms Resistant to other Antibiotic . However, there is less activity in streptococci . pneumococci . gonokokkov . staphylococci . meningococcus .

After the introduction of antibiotic   It is rapidly excreted from the body. Generally, it occurs in the urine, but some of the drug is excreted in the bile. Maximum plasma concentration is achieved very quickly - within half an hour after treatment. The degree of binding to plasma proteins - 25-40%.

Indications

Klaforan used for treatment of the following infectious and inflammatory diseases:

• infections of the skin and soft tissues;
• septicemia ;
• endocarditis ;
• infections of the central nervous system;
• respiratory tract infections;
• bone and joint infections;
• bacteremia ;
• urinary tract infections;
• intra-abdominal infections.

Moreover, the drug can be used to prevent infectious complications after surgery in the gastrointestinal tract and the reproductive system.

Contraindications

As contraindications to the use of the funds indicate hypersensitivity to its components, and the local anesthetics , Children up to age 2, 5 years, using intravenous Lidocaine . heart failure . intracardiac blockade   without pacemaker .

In addition, this drug is not recommended for use in pregnancy   and breastfeeding .

Side effects

In the application may appear klaforan allergic reactions   (from the gastrointestinal tract, cardiovascular system, skin, central nervous system, liver) vomiting . diarrhea . nausea , Abdominal pain and injection site.

Furthermore, from the gastrointestinal tract may increase the activity of liver enzymes and / or bilirubin With the hematopoietic system - neutropenia , CNS - encephalopathy With the urinary system - the deterioration of the kidneys.

In rare cases, there interstitial nephritis . agranulocytosis . thrombocytopenia . eosinophilia . hemolytic anemia . arrhythmia .

You may also receive weakness . superimposed infection . fever .

And the treatment of borreliosis   may occur during the first few days Jarisch-Herxheimer . itch . leukopenia . labored breathing , skin rash, fever , Increased liver enzyme levels, and discomfort in the joint.

Instructions for use klaforan (method and dosage)

Those who appointed klaforan, instructions for use involves the introduction of various schemes depending on the severity of the disease (intramuscularly or intravenously). Typically, 1 g of 3 times a day, urinary tract diseases administered the same dose 2 times a day for health 2g taken 3 times a day, with gonorrhea   0 or 5 g 1 taken singly. How many days and stabbing the exact dosage prescribed by the doctor.

Children weighing up to 50 kg, is generally administered from 50 to 100 mg / kg by intravenous or intramuscular injections with an interval between 6-8 hours. In the case of severe infections, the dosage can be increased by 2 times, but in any case does not exceed the dose of two children weighing more than 50 kg of drug is administered in the same dosage as for adult patients.

Before the operation during the induction of anesthesia for the prevention of infections introduced 1 g intravenously or intramuscularly, moreover, the injection was repeated after surgery after 6-12 hours.

Klaforan can also be administered at caesarean section   while clipping on the umbilical vein. In this case done by intravenous injection of 1 g, and after 6-12 hours, it was repeated intramuscularly or intravenously.

Instructions for use klaforan provides the following methods of solution for internal administration:

• intramuscular injections   - 1 g dissolved in 4 ml of pure water and 2 g dissolved in 10 ml of pure water. Furthermore, as the solvent may be 1% solution Lidocaine But strictly forbidden in the case of intravenous administration;
• Intravenous injections   - 1 or 2 g is dissolved in 40-100 ml of clean water or infusion solution. Thrust is slow (about 4 minutes) in order to avoid Arrhythmia . Infusion may be used: water for injection, Ringer solution, 5% glucose solution, and solutions yonosteril Sodium lactate, 12% reomakrodeks , 0.9% sodium chloride, gemaktsel 6% makrodeks . In tutofuzin .

For the preparation and application klaforan necessarily need to ensure aseptic conditions .

Overdose

There is a probability of occurrence reversible encephalopathy   using beta-lactam antibiotics . Treatment is symptomatic.

Cooperation

Probenecid combined with delays Klaforanom excretion and increases plasma concentration cefotaxime .

In addition, there is a possibility that klaforan will potentiate the nephrotoxic effects of drugs that have a nephrotoxic action.

Klaforan solution can not be used together with other solutions antibiotics   in an infusion solution or a syringe.

Terms of sale

The drug is sold by prescription only.

Storage conditions

Keep the medication you need in a cool place that is sheltered from direct sunlight. We can not allow the drug to children. The temperature should be 25 ° C.

Shelf life

The drug should be stored no longer than 2 years.

Analogs

Match code ATC 4th level:

• Cefotaxime
• Cefixime
• Tseforal Soljutab
• Pantsef
• Cefodox
• Supraks Soljutab
• Ceftriaxone

The product has the following analogues:

• Klafotaksim ;
• Intrataksim ;
• Liforan ;
• Kefoteks ;
• Oritaks ;
• Klafobrin ;
• Oritaksim ;
• Spirozin ;
• Taltsef ;
• Tsetaks ;
• Tirotaks ;
• Tsefabol ;
• Tartsefoksim ;
• Tsefantral ;
• Tax-of-bid ;
• Tsefosin ;
• Rezibelakta ;
• Cefotaxime . Cefotaxime Lek . Sandoz cefotaxime . Cefotaxime-Vial . Cefotaxime-Promed . Cefotaxime DS . Cefotaxime sodium . Cefotaxime Elf . Cefotaxime-LEKSVM . Cefotaxime sodium salt .

Cefotaxime and klaforan - what's the difference?

Sometimes the forums ask about Cefotaxime   klaforan and the difference between these drugs and which one is more effective. Experts say that by the action of these drugs - analogues. The difference lies mainly in the fact that klaforan - drug import and Cefotaxime   - Russian. Many patients, however, argue that effective klaforan his Russian counterpart.

Reviews Klaforane

Reviews Klaforane indicate that the tool is very effective in gonorrhea . It is often appointed venereologists. Usually the course is designed for 7-14 days. However, reviews of Klaforane and also report that this tool can cause inflammation at the injection site. As a rule, this is due to incorrect administration of the drug, so that this will need to be monitored closely, especially when children are doing injections.

Price klaforan where to buy

Price klaforan pharmacies may be different. The average price - 140 rubles. In some places, however, the price klaforan be 120 rubles and below.

Get the best price and buy