Zoreks

Description overdue on 08/01/2014

• Latin name: Zorex
• ATC code: V03AB09
• Active substance: Dimercaprol + calcium pantothenate (Natrii dimercaptopropansulfonas + Calcii pantotenas)
• Manufacturer: JSC "Valenta Pharmaceuticals", Russia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Zoreksa (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The composition of the capsules of 150 mg ± 7 mg capsules and 250 mg + 10 mg include the same substance, the difference is only in the ratio.

Each capsule consists of active substances: monohydrate Dimercaprol ( unitiol ) - 150 mg capsules of 150 mg ± 7 mg and 250 mg capsules of 250 mg + 10 mg calcium pantothenate   - Respectively 7 mg or 10 mg.

Also, it is composed of auxiliaries: 113 5 (120 2 in the second embodiment, capsule) mg microcellulose, 9, 1 mg (12 2 mg), citric acid monohydrate, 29, 3 mg (40 2 mg), pregelatinized starch, 30 mg (50 mg) magnesium hydrogen phosphate trihydrate 6, 1 mg (9, 4 mg) povidone 5 mg (8 mg), colloidal silica ( aeroforce ).

The hard gelatin capsule consists of gelatin . titanium dioxide   (E171) and the dye azorubina (E122).

Product form

Zoreks (Zorex) is available in capsule form of 150 mg ± 7 mg and 250 mg + 10 mg. Capsules are packed in blisters made of PVC film and aluminum foil printed lacquered, 2 or 5 pcs. (250 mg + 10 mg) or 10 pieces. (150 mg ± 7 mg).

Every Valium planimetric package of 10 pieces. (150 mg ± 7 mg), and 2 pcs. (250 mg + 10 mg) were placed in a cardboard pack. Blisters 5 pcs. (250 mg + 10 mg) was placed in a two pack of cardboard.

Pharmacological action

Zoreks has complexing, hepatoprotective . detoxification   and antioxidant effect   on the human body.

Very detailed description of the effect of the drug on the body can be found at drug Zoreks (Zorex) - zorex.ru.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Zoreks is complexing the drug, as well as donator of sulfhydryl (thiol) groups . His is detoxification effects (including with respect to the half-life of products ethanol Heavy metals and their compounds, arsenic compounds). During the clinical trials revealed antioxidant   and hepatoprotective effect unitiola .

The presence of active sulfhydryl groups allows unitiol , interact with thiol poisons As well as the half-life of the products of alcohol (alcohol ethanol ) Which are in the blood and tissues, and to form with them the compounds (complexes), which have no toxic effect on the body and excreted in the urine.

In the case of admission into Zoreksa unitiol   It enters the liver. There he builds a high speed connection to physiologically irreversible acetaldehyde. This causes the removal of alcohol, ethyl alcohol or rather from other organs and tissues. The drug also activates the enzyme alcohol dehydrogenase Thereby enhances the process of ethanol oxidation, neutralization of toxic agents that alcohol which performs liver enzyme system .

Calcium pantothenate Present in the formulation Zoreks, has the property to enhance detoxification action that has unitiol. Calcium pantothenate is rapidly absorbed in the intestine and then splits and frees pantothenic acid . This acid is involved in carbohydrate and fat metabolism, has a stimulating effect on the formation of corticosteroids, significantly accelerates the recovery processes.

Pharmacokinetics

Absorption occurs quickly enough. As a result of ingestion of a capsule which contains 250 mg unitiola, its maximum concentration in the blood is achieved in 1.5 hours and is equal to 90-140 mg / l. The drug in the body is on the average 9-11 hours, of which in the gastrointestinal tract - 15-20 minutes.

Calcium pantothenate   Pi is well absorbed in the intestines and gets after absorption is split, freeing the pantothenic acid.

Half life   drug lasts 7, 5 ± 0, 46 hours.

Approximately 60% of the drug excreted in the urine is excreted in the feces.

Indications

Zoreks used in the following cases:

• alcohol withdrawal syndrome   (used for the prevention and treatment of a hangover state);
• chronic Alcoholism   (part of the Assignment of complex therapy);
• acute and chronic poisoning with organic compounds and inorganic substances such as arsenic, mercury, gold, chromium, cadmium, cobalt, copper, zinc, nickel, bismuth, antimony;
• intoxications Caused by the use cardiac glycosides .

Contraindications

Zoreks is contraindicated in:

• severe liver disease during the stage of decompensation;
• severe kidney disease during the stage of decompensation;
• aged less than 18 years;
• increased sensitivity to component drug substances.

The drug should be taken with caution, if dropped arterial pressure .

Side effects

A side effect of the drug may be the occurrence of allergic reactions, but they are infrequent. In rare cases, there is the appearance of pruritus, hives , Rashes on the skin, mucous membrane, mucosal edema,   genital itching . stomatitis . Very rarely have an allergic reaction to the type of angioedema . Stevens-Johnson syndrome . This syndrome is manifested by a sudden fever, malaise, mottled vesicular   or bullous rash   in the skin, genital mucosa, oral cavity to the anus).

If you experience these symptoms, you must stop the medication and seek medical advice. A higher risk of allergic reactions are persons suffering from asthma   or those who have a history of allergy.

Applying too high doses can cause nausea, dizziness . tachycardia , Pale skin.

Instructions for use Zoreksa (method and dosage)

According to the instructions on Zoreks, this medication is taken orally. Drink it should be for 30 minutes before a meal, wherein the capsule should not chew. After taking the drug need to drink a small amount of water.

Dosage depends on the case:

• For prevention hangover   drink 1 capsule (250 mg ± 10 mg) Zoreksa after drinking alcohol the evening before going to bed.
• If necessary, treatment alcohol withdrawal syndrome drug taking 1 capsule (250 mg ± 10 mg), 1 or 2 times during the day. If necessary, the daily dose may be increased up to a dose of Dimercaprol   750 mg, and the number of reception - 3 times per day. The drug should be used from 3 days to a week, until it stops the symptoms of intoxication.
• In the complex in the treatment of Alcoholism   We need to take 1 capsule (150 mg ± 7 mg) Formulation 1 or 2 times per day, for 10 days.
• For the treatment of poisoning caused by arsenic or heavy metal salts, prescribed 300-1000 mg / day of the drug (the calculation is on Dimercaprol ). This amount Zoreksa be taken for 2-3 hours. Treatment is carried out for a long period of time from a week to 10 days.

Overdose

Symptoms of overdose appear in cases of exceeding the required dose of 10 times or more.

The symptoms, the occurrence of which is possible in overdose include: shortness of breath , Development hyperkinesis , Lethargy, weakness, stupefaction, the emergence of short-term seizures.

In case of overdose should be washed stomach, take Activated carbon , Laxatives. Also shown is symptomatic therapy, in severe cases, is necessary to conduct oxygen therapy , Recommended the introduction of dextrose .

Cooperation

Dimercaprol   It has the property of restoring the previously reduced sensitivity to nitroglycerin .

Calcium pantothenate   improves efficiency cardiac glycosides It causes a decrease in the toxic effect of drugs arsenic aminoglycosides Antibiotics streptomycin series   and sulfonamides .

You can not combine Zoreks with medicines that contain heavy metals.

It is not recommended to combine with alkalis, as in this combination drug is rapidly degraded.

Terms of sale

Allowed sold without prescription.

Storage conditions

It should be stored in a dry place, protected from light, at a temperature not exceeding 25 ° C.

The place where the drug is stored, should be inaccessible to children.

Shelf life

3 years.

Babies

Contraindicated for use under the age of 18 years.

During pregnancy and lactation

Data on the use of medications during pregnancy and during lactation is not. Therefore, during pregnancy and breastfeeding is prohibited its use.

Reviews

Reviews Zorekse quite diverse. Most reviews at Zorekse hangover   agree that this drug is effective, but the body's tendency to allergies often manifest side effects.

Price Zoreksa where to buy

Price Zoreksa pharmacies in the range of 121 to 504 rubles depending on the form of.

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