Description overdue on 11/21/2014
- Latin name: Naklofen
- ATC code: M02AA15
- Active substance: Diclofenac (Diclofenac)
- Manufacturer: Krka, Slovenia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for Naklofena (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
One tablet contained 50 mg diclofenac + Corn starch, povidone, magnesium stearate, hypromellose, iron oxide yellow, methacrylic acid and ethyl acrylate as copolymer, lactose monohydrate, microcrystalline cellulose, silicon dioxide, red iron oxide, titanium dioxide, talc, propylene glycol.
As a part of Candles (per suppository): 50 mg diclofenac sodium + Solid fat.
One ampoule means comprises: 75 mg diclofenac , Benzyl alcohol, sodium bisulfite, water, propylene glycol, sodium hydroxide.
Gel for external use It contains (per gram) diclofenac - 10 mg + additional substance (macrogol, isopropanol, anhydrous sodium sulfite, decyl oleate, paraffin oil, carbomer, diethanolamine, propylene glycol, cetomacrogol).
Product form
The drug release in the form of a brown-yellow round tablets. Form - biconvex, smooth. Each tablet is coated enterosoluble film cover. In cardboard packs of 2 packages in the package - 10 tablets.
The drug is produced in the form of a cone-shaped candles of white or white with a yellow tinge. If you divide a candle, you can see the inside of a white or yellowish waxy mass. Rectal suppositories are in strips of 5 pieces, 2 strips are in a carton box.
The solution for intramuscular injection - a clear, colorless or slightly yellowish liquid. The drug produced in vials of 3 ml, 5 vials in a blister or plastic tray.
It is also a means of producing a white, homogeneous gel for external use, the aluminum tubes to 60 grams.
Pharmacological action
Anti-inflammatory, analgesic, antipyretic.
Pharmacodynamics and pharmacokinetics
Thanks to the active components of the composition of the drug - diclofenac , Considered Naklofen NSAIDs . Also analgesic and antipyretic .
The active substance reduces the intensity of synthesis prostacyclin . thromboxane and prostaglandins by inhibiting the activity of enzymes COX-1 and COX-2 . there is a significant reduction prostaglandins in urine synovial fluid and gastric mucosa.
The drug affects not only antiprostaglandinovy phenomenon But also normalizes the increased permeability, microcirculation, inhibits the activity mediators inflammation. Active substance means reduces the overall power of inflammation, inhibits the synthesis process ATP .
Pain relief is due to the ability of the drug to reduce the algogenov bradykinin . Also diclofenac reduces the excitability of the centers responsible for thermoregulation in certain regions of the diencephalon. Even after prolonged use analgesic ability of drugs not reduced.
After 40 -60 minutes after absorption from tablets GI active ingredient reaches its maximum in the blood plasma. With / m introducing a maximum is reached within an hour, using spark - an hour. After applying the gel for topical diclofenac is very quickly reaches its target organs, penetrates into muscle tissue, joint cavity, subcutaneous tissue and joint.
Subject to the rules of use of funds, it does not accumulate in the body. About 90% of the active substance is bound to plasma proteins, penetrates synovial fluid and breast milk. The target organs gets about half penetrated into the body diclofenac .
The drug undergoes hepatic reactions metabolism . Metabolites produced by glucuronic acid with the participation of enzymes cytochrome P450 CYP2C9 . The half - 2 hours. Displays the drug via the kidneys as inactive metabolites in the bile and a small amount (about 1%) - in an unmodified form.
Elderly patients with kidney or liver disease pharmacokinetic figures remain virtually unchanged.
Indications
Indications for use Naklofena quite varied:
- drug used to relieve symptoms of rheumatism . rheumatoid arthritis . seronegative spondioloartite ;
- at gout . arthritis and pseudogout ;
- at arthrosis . spondylosis and other degenerative diseases of the spine;
- treatment bursitis . myositis . tendivita . periarthritis . synovitis ;
- at dysmenorrhea ;
- treatment Permoneydzha disease-Turner ;
- in kidney and liver colitis .
Also the medicine is used for acute migraine pain During and after dental operations for the relief of pain associated with Oncology , Pain after surgery and after trauma ( injuries . sprains, ligament damage ).
The drug is prescribed for infections and inflammations Otolaryngology : The otitis media, pharyngitis, tonsillitis At fever .
Injections Naklofena appointed, if the use of another dosage form is not possible.
Contraindications
The drug is contraindicated:
- in the presence of allergies to diclofenac or other NSAIDs ;
- in the last trimester pregnancy ;
- at stomach ulcer and duodenum (to oral dosage forms);
- at asthma ;
- in the presence of destructive and inflammatory bowel disease (tablets and suppositories);
- beyond coronary artery bypass grafting ;
- bleeding disorders;
- children up to 6 years.
Care should be taken:
- at CHD ;
- hyperlipidemia and dyslipidemia ;
- at diabetes ;
- 1 and 2 trimester of pregnancy;
- smokers often drink alcohol to persons.
Side effects
Upon receiving means may be side reactions:
- pain epigastric , Vomiting, diarrhea and nausea, anorexia , Increased levels of liver enzymes;
- gastritis , Worsening Hemorrhoids Ulcers on the gastric mucosa, jaundice ;
- dry mouth and mucous membranes, stomatitis . pancreatitis ;
- drowsiness . dizziness and headache . paresthesia , Seizures, tremor Irritability;
- vertigo , Hearing and visual impairment, taste;
- hematuria , Renal failure;
- leukopenia . thrombocytopenia . agranulocytosis . anemia ;
- anaphylactic shock , Reduction Blood Pressure , Increasing BP . vasculitis , Palpitations;
- cough . breathlessness . pneumonia ;
- Stevens-Johnson syndrome , hair loss, hives . itch .
The solution for injection can cause irritation and soreness at the injection site pain, edema and redness.
Gel side effects is extremely rare. You may experience photosensitivity , Itching, peeling and swelling on the treated surface. During and after application may feel a burning sensation, hives . eczema Possible anaphylactic reactions .
Instructions for Naklofena (method and dosage)
The duration of intake, dosage form and strength should be determined by the attending physician.
The tablets are taken orally, after or during a meal without sharing with liquid.
Patients whose weight exceeds 45 kg, 50 mg administered by means of two or three times a day. After reaching the desired effect it is recommended to gradually reduce the dose. Max diclofenac received per day is 150 mg.
Candles are administered rectally. The initial daily dosage for adults is 100 mg, the maximum - 150 mg. At the age of 15 to 18 years should be administered no more than 2 suppositories per day.
Injections Naklofena, instructions for use
Injections produced exclusively by intramuscular injection. At one time the maximum amount of the drug - 75 mg 12 hours later can enter the next dose.
Exceptions are patients with renal colic, it is possible to make a prick 2, with an interval of half an hour.
If parallel assigned other preparations containing diclofenac , Remember the maximum daily dose (150 mg).
Do not mix with other drugs Naklofen in vials in the same syringe.
The gel was applied to the affected part of the body and gently rubbed into the skin, 2 or 3 times a day, no more than 10 cm gel. The course of treatment should not exceed 10 days.
For children from 6 to 12 to be applied a strip of less than 3 cm, the frequency of application - not more than 2 times per day.
Overdose
Most often it occurs when taking an overdose of pills.
Symptoms of overdose are: nausea, tinnitus, vomiting . diarrhea . convulsions , Bleeding in the gastrointestinal tract.
As a therapy administered gastric lavage, enterosorbents , Symptomatic treatment.
Cooperation
Concentration Digoxin , Preparations lithium . cyclosporine and Methotrexate It may be significantly increased under the action of the drug.
Effect of antihypertensive and hypnotics means in combination with means decreases.
The drug reduces the effectiveness of hypoglycemic agents .
The drug increases the toxicity glucocorticosteroids . Paracetamol .
Parallel reception acetylsalicylic acid reduces efficiency diclofenac .
Precautions to combine the drug with
- Tsefamandol . Tsefotetanom . Plicamycin . Ceftazidime and Valproic acid ;
- selective serotonin reuptake inhibitor, ethanol, Corticotropin . Hypericum perforatum . Colchicine due to the increased risk of bleeding;
- means causing increased sensitivity to light;
- blockers kanaltsievoy secretion ;
- antibacterial drugs group quinolone .
When combined with funds cyclosporine and preparations of gold nephrotoxicity enhanced.
You can not mix diclofenac and other drugs in the same syringe.
Terms of sale
To purchase medicines need a prescription.
Storage conditions
The drug was stored at a temperature not exceeding 25 degrees away from children.
Shelf life
5 years.
Candles - 4 years.
Cautions
If you take medication for more than 2 weeks, the need to control the level liver enzymes .
If there are signs of liver disease should stop taking money and see a specialist.
While taking the drug may increase existing diseases in history.
Receiving funds may negatively affect women's Fertility .
For elderly patients essentially choose the minimum active and effective dosage.
Before the drug (all formulations except the gel) should avoid driving and other processes requiring high concentrations and reaction rates.
The gel does not apply under the occlusive dressings On open wounds, damaged skin.
After using the gel should be thoroughly wash your hands and avoid contact with the eyes and mucous membranes, avoid exposure to direct sunlight.
Analogs
Diklovit
Artrozilen
Olfen
Fast Fanigan
Feloran
Fastum gel
Nise
Diclofenac
Dolgit
Dolar
Flamidez
Ketonal
Ketorol
Indomethacin
The most common counterparts: Diklak, Diclofenac, Voltaren, Rapten, Naklofen Duo, Almiral, Diclobru, Dikloberl, Dikloreum, Olfen . Indomethacin, Fanigan Fast, Feloran, Fastum gel, Nise, long, Dolar, Flamidez, Ketorol, Ketonal.
Reviews
In preparation wide range of indications, and yet, no matter what kind of disease is not worried Naklofen copes well with this task. Judging by the reviews, the drug quickly and permanently eliminate the pain. Adverse reactions are rare. Most of all - it allergy (itching and skin irritation, hives ) Or side effects from GI (nausea, problems with a chair). Many people like the low cost of funds.
Price Naklofena
Cost Naklofena tablets - About 100 rubles per 20 pieces.
Price Rectal suppositories 70 rubles per 10 pieces.
Cost Naklofena as a solution for injection - 47 rubles per 5 vials of 3 ml.
Topical gel It can be bought for 200 rubles (60 grams).
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