Description overdue on 10/27/2014
- Latin name: Tergynan
- ATC code: G01BA
- Active substance: Ternidazol (Ternidazole), Neomycin sulfate (Neomycine sulphate), Nystatin (Nystatin), prednisolone sodium metasulfobenzoat (Prednisolone metasulphobenzoate sodium)
- Manufacturer: Laboratoires Bouchara-Recordati, France
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications for use: what cures Terzhinan and when it is expedient to appoint
- Contraindications
- Side effects
- Candles Terzhinan: instructions for use
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In addition to the active components of the vaginal tablets Terzhinan include: wheat starch (Amylum tritici), colloidal silicon dioxide (Silicii dioxydum colloidale), sodium starch (type A; Natrii amylum), Magnesium Stearate (Magnesium stearate), lactose (Lactose).
Product form
The dosage form of the drug Terzhinan - vaginal suppositories.
Pharmacological action
Terzhinan - a drug from the group combined antimicrobial, antiseptic and antifungal drugs Used in gynecological practice.
The physiological action and pharmacological properties of the drug due to the activity of its constituent active ingredients. The treatment Terzhinanom a marked:
- trihomonatsidny ;
- antibaktrialny ;
- antifungal ;
- anti-inflammatory effects .
Pharmacodynamics and pharmacokinetics
The action is part of the Terzhinan ternidazola sent to death Trichomonas . Moreover, it provokes death anaerobes and in particular active against facultative anaerobes genus Gardnerella .
Neomycin It is antibiotic from the group aminoglycosides . Its mechanism of action is associated with the ability to permanently break the ribosomal level protein synthesis in cells of pathogenic microorganisms .
Suppressing protein synthesis . neomycin causing disturbances in the transcription of the genetic code and provokes death Microbial cells . It has been experimentally proved that the sensitivity to it, are typically aerobic bacteria : Corynebacterium (C. amycolatum), Listeria (Listeria), and methicillin - Sensitive aurococcus (MSSA).
Furthermore, it was found that the sensitivity to neomycin possess Gram negative bacteria Including including Pseudomonas aeruginosa (P. aeruginosa), generally stable to the action of antibiotic .
Nystatin represents antimycotic agent from the group polyene antibiotics . Communicating with the statement in cell membranes of fungal ergosterol It causes them to be damaged and thus provokes the death of fungi.
Nystatin affects only the eukaryotes . They are susceptible to the fungi belonging to the genus Candida Including strains including Candida albicans and Candida glabrata .
Prednisolone - this glyukokortikostrerodinoe drug . The local application of its therapeutic activity is determined anti-inflammatory . antiallergic and antiexudativ action. The latter is due vasoconstrictor effect of prednisolone .
Included in the vaginal tablets excipients ensure the integrity vaginal epithelial tissue for different infectious and inflammatory diseases And pH-indicators support balance within the physiological range.
The pharmacokinetic characteristics Terzhinan not been studied, due to the low systemic absorption of the drug.
Indications for use: what cures Terzhinan and when it is expedient to appoint
Indications for use of vaginal tablets are accompanied by inflammatory processes infectious diseases vulvar Caused by hit and active vital activity in the vagina sensitive Terzhinanu pathogens .
Thus, vaginal tablets from what are they? The drug is prescribed for women who have been diagnosed:
- vaginitis Provoked by banal pyogenic microflora ;
- chronic recurrent colpitis (nonspecific vaginitis);
- vaginal dysbiosis ;
- Trichomonas vaginitis ;
- vaginitis Flooding caused by fungi Candida albicans ;
- vaginitis mixed nature of origin.
Terzhinan also often prescribed as a preventive measure to prevent the development vaginitis women to be small and major surgery in pelvic organs .
In particular, the drug is used before the birth, the procedure surgical abortion . diathermocoagulation (feasible is the introduction of the tablets both before the procedure and after it), contrast X-ray examination of the uterus and fallopian tube patency ( uterosalpingography ) Before installing IUD and after this procedure, etc ..
Terzhinan also used as a means to prevent complications antibiotic therapy .
The use of candles in the Terzhinan ureaplasmosis
Despite the fact that the active growth ureaplasmosis most often associated with failures in work immune system , Treatment with immunomodulating drugs It may not produce the desired result.
In this situation, recourse to the destination special antibacterial agents or antibiotics . Very often ureaplasma doctors recommend Terzhinan, which operates on a wide range pathogens and provides pronounced antiinflammatory effect .
A valuable feature of the drug is that, provoking the death of bacteria and fungi He thus does not violate the natural microflora of the vagina.
Terzhinan thrush
Terzhinan recommended for the treatment of women who have thrush accompanied suspected of having secondary inflammation and \ or Infection secondary microflora .
In addition to the use of Terzhinan resort in cases where symptoms are so bright that they should be cut short as soon as possible.
In some cases, the drug complex shown as substitute for therapy if previous treatment with other antifungal agents It proved to be ineffective.
Reviews candlelight at thrush Left patients and practitioners, gynecologists, suggest that Terzhinan successfully cures fungal infection , Without provoking the development of undesirable side reactions.
Contraindications
Contraindications to the appointment are Terzhinan allergic reactions and individual intolerance of any of its constituent components. If drug treatment is accompanied Allergies , The physician should replace it with a more appropriate.
Vaginal Tablets are not intended for treatment of patients younger than 16 years old.
Side effects
Terzhinan very rarely provoke side effects. Since candles are used locally, their constituent components are absorbed into the systemic circulation in very small concentrations.
Therefore, in most cases, they are registered only provoke local reactions, which are expressed as allergy symptoms , Sensations of burning, tingling, itching, pain and irritation at the injection site.
Systemic effects during treatment with medication occur in isolated cases. Possible reaction to the use of glucocorticosteroids (and, in particular, prednisolone ) Is a slow process of healing of wounds and fractures, also in individual patients may occur atrophic processes in the mucosa .
Candles Terzhinan: instructions for use
Instructions for use Terzhinan recommends vaginal tablets administered deeply into the vagina of a once a day every day for ten days.
Prior to entering the tablet in the vagina, it must be dipped in water for about 30 seconds (or in a wet hand hold approximately two minutes). If the pill is administered during the day, not at night, after its introduction should not lie down for at least ten minutes.
The best procedure is for the evening. This is due to the fact that after the morning administration Terzhinan may appear yellowish in color separation, which are normal during the course of treatment.
If the goal of treatment is normalization of microflora imbalance in the vagina, and the removal of the symptoms of inflammation , The duration of treatment depending on the clinical picture and the prescription is six to ten days.
If the cause of the drug is thrush , A course of therapy is increased to 20 days. Three days after it is recommended to take follow-up examination and tests that will confirm or complete recovery or point to the need to re-pass the course.
In pregnancy, the dose and duration of treatment is determined by the doctor depending on the clinical situation.
Can I use candles during menstruation?
Very often in patients who have shown treatment Terzhinanom, the question arises whether it is possible to use during menstruation these pills. The instructions to the drug manufacturer indicates that the monthly is not an indication for treatment discontinuation.
Overdose
To date, reports of overdose Terzhinanom not. Since the components of the drug is practically not absorbed into the blood, it is considered impossible to overdose.
Potentially, an overdose of drugs may increase the severity of side reactions. This requires the preparation and appointment of symptomatic treatment.
Cooperation
Drugs and other forms of interaction Terzhinan not identified.
Terms of sale
Prescription.
Storage conditions
Packaging vaginal tablets should be stored at room temperature (not more than 25 ° C).
Shelf life
36 months.
Cautions
The results of studies on the effectiveness of the drug components Terzhinan demonstrated that the concentration of the active ingredients in this preparation for local therapy (but not for ingestion per os) above toxic concentrations, which is determined by the development of resistance to Antibacterial .
In such circumstances, it is assumed that the activity strains of infection Theoretically resistant to the active ingredient, it will be suppressed by high concentrations.
In addition, it is likely that high concentrations of active ingredients can have Terzhinan synergistic (enhancing effect each other) impact on pathogens Which on its action spectrum is much broader than that of each individual active component.
Keep in mind that preparations Nystatin Intended for intravaginal use may damage the latex contraceptives.
Given that the active components Terzhinan potentially slightly absorbed into the systemic circulation It should be remembered that the application of systemic corticosteroids patients diagnosed with osteoporosis . arterial hypertension and heart failure It requires monitoring at the appropriate expertise.
Seeing a specialist is also required under existing or marked in history peptic ulcers . TB . Glaucoma . hypothyroidism , Serious emotional disturbances, myopathy Provoked by the use of glucocorticosteroids . hepatic insufficiency . epilepsy . Diabetes Recently happened myocardial infarction .
Is it better or Terzhinan Polizhinaks?
The action exerted by the drug Polizhinaks It is identical to the action, which has Terzhinan. However, the study, which aims to comparative evaluation of the activity of the components of these two drugs in models in vitro Showed that unlike Terzhinan Polizhinaks no effect on MRSA (methicillin-resistant Staphylococcus olotisty) streptococci and enterococci . However, he showed great activity against Gardnerella vaginalis (G. vaginalis).
Also, women are often asked the question "What is better: Hexicon or Terzhinan? Terzhinan or Penotran? ". Both of these drugs have a similar effect with Terzhinanom, but differ from the latter composition.
That is, the active ingredients of each of these drugs can show different activity for the same Microorganisms . Therefore, to decide which one is better drugs and which would be less effective in each case can only physician.
Terzhinan is an effective means for women. What men?
Gynecologists are constantly reminded of the fact that all infectious and inflammatory diseases For the treatment of which is shown Terzhinan, need to be addressed both by women and by men. To do this, both partners must undergo treatment antibacterial drugs .
Neglect of this point is fraught with the fact that all the unpleasant symptoms that appear when a particular disease will come back. For the entire period of treatment is also recommended to abstain from sex, but some doctors sometimes still allow the partners to conduct the usual sex life.
The main condition - the mandatory use of condoms and the complete absence of any side effects reproductive system (for both women and men).
For example, some women during sexual intercourse (or some time after) may occur strong burning complaints, men are more frequently associated with discomfort and some discomfort.
In any of these cases, the optimal solution is to avoid sexual activity until completion of treatment. It is important to remember that sexual intercourse must necessarily take place only before the next part will be introduced vaginal tablet (not after!).
Analogs Terzhinan
Many patients received the drug from a doctor appointment, try to find an analogue Terzhinan cheaper.
Currently Terzhinan none. For women who are diagnosed bacterial vaginosis or vaginitis It can be assigned a number of drugs, such as: Neotrizol . Polizhinaks or Meratin Combi .
Although they are similar in action with Terzhinanom latter it is unique in its composition and complex impact on the ability of inflammatory and infectious processes Affecting mucous vulvar .
The average price of analogues candles Terzhinan varies from 96 to 120 UAH.
Terzhinan and alcohol
Drinking alcohol during treatment with vaginal tablets Terzhinan not recommended.
Terzhinan during pregnancy and lactation: what candles Terzhinan prescribed to pregnant and lactating women
Instructions on Terzhinan during pregnancy allows the use of the drug during this period of a woman's life, but only under the supervision of a physician, a leading pregnancy.
Tablets are contraindicated in 1 trimester, in 2 and 3 trimester of pregnancy drug, usually prescribed for inflammation of the vagina (vaginitis) Which is not caused by a single pathogen, but several (ie and bacteria And fungi ). This disease is called together, and for its treatment approach combined drugs, which also includes antibiotic And antimycotic agent .
The low degree of absorption in Terzhinan systemic circulation It eliminates the possibility of overdose and the likelihood of transmission components of the drug through the bloodstream to the developing fetus.
Thus, candles Terzhinan during pregnancy do not have a negative impact on the body of the unborn child. Besides taking medication is permitted irrespective of oral preparations, as its active components do not interact with other components of medicines.
Permission is also Terzhinan use during lactation. The main condition of the destination agent is correct diagnosis, confirming the need for treatment. The drug is prescribed in the event that more sparing means and methods do not resolve the itching and burning.
However, like any other drug, Terzhinan pregnant and nursing women should not be used unless absolutely necessary and without prior consultation with the doctor.
Reviews Terzhinane
In his review of candlelight Terzhinan almost all women as the main advantages of this drug note that the latter is very simple to use, available (pills Terzhinan are relatively inexpensive drugs), in most cases well tolerated and rarely provokes the development of complications and undesirable side reactions.
If we talk about the effectiveness of the drug in thrush , The reviews of Terzhinane forums suggest that this drug has proved itself as an effective and safe tool that allows you to quickly cure is activated by any decrease in immunity chronic thrush .
Reviews Terzhinane during pregnancy and breastfeeding indicate that very often the drug is an effective means (even in cases where other drugs have not helped to solve the problem).
Negative reviews are mainly related to hypersensitivity reactions to the drug.
Some women also write that they had begun spotting after the introduction of one or more tablets Terzhinan. Gynecologist also claim that this phenomenon has nothing to do with the use of the drug and to determine the cause of its origin is necessary to pass an additional examination.
Price Terzhinan
Price Terzhinan in Ukraine
The average price of candles Terzhinan №10 in Ukraine - 155-165 UAH. Buy №6 pills can be an average of 88 UAH: Odessa they sell for 80 to 87 UAH Kiev pharmacies - by 90-99 UAH Kharkov price of the drug - 90-92 UAH.
How much are candles in Russia?
Price Terzhinan tablets №10 - from 360 to 405 rubles. The price of candles Terzhinan №6 - from 215 rubles. Find out the exact cost of 6 or 10 tablets can be as specific online pharmacy network, and calling the desired pharmacy.
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