Description overdue on 11/20/2014
- Latin name: Gyno-Tardyferon
- ATC code: B03AD03
- Active substance: Iron sulfate + Folic acid (Ferrous sulfate + Folic acid)
- Manufacturer: PIERRE FABRE MEDICAMENT PRODUCTION (France)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instruction in Guinot-Tardiferon (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The main components: iron sulfate (II) and folic acid . Each tablet contains 256 depot, 3 mg iron sulfate in the form that corresponds to 80 mg of pure iron and 350 mcg of folic acid.
Additional components: dibutyl phthalate, ascorbic acid , Magnesium stearate, castor oil, talc, anhydrous mukoproteoza.
The shell consists of beeswax, titanium dioxide.
Product form
Gyno-Tardiferon is available in tablet form. The tablets have a lenticular shape. Special sheath provides prolonged, sustained drug efficacy with a slow release of active ingredients. The package contains 30 pieces.
Pharmacological action
Combined stimulant of hematopoiesis . antianemichesky medicine .
Ferrous sulfate is a salt of iron, which is directly involved in the process of synthesizing Hemoglobin . Iron is found in myoglobin, enzymes and the hemoglobin. Admission iron salts allows you to quickly make up for the lack of them. If iron deficiency is marked dryness of the skin, heart palpitations, fatigue, dizziness , Marked weakness.
Folic acid take part in the formation of normoblasts, maturation megaloblasts, choline metabolism, synthesis of nucleic acids, amino acids , Pyrimidine and purine. When gestation pregnancy Folic acid protects against teratogenic factors contributing to the normal tab organs and fetal development.
Mukoproteazu obtained from the intestines of animals, it is the high molecular weight fraction of natural origin. Mukoproteaza can enhance the bioavailability of the iron ions. Ascorbic acid promotes the absorption of iron.
Neutral shell tablet provides a gradual absorption of the active ingredients in the small intestine, protecting gastric mucous wall of irritating and preventing unwanted side effects from the digestive tract.
Pharmacodynamics and pharmacokinetics
The bioavailability of iron reaches 10-30%. In the distal part of the small intestine is slow absorption of active ingredients. Folic acid begins to be sucked back in the duodenum. Plasma proteins bind to the iron by 90%. Deposition occurs in the form of ferritin and hemosiderin, part settles into the muscle tissue in the form of myoglobin . Iron output sweat, urine and feces.
Folic acid binds to plasma proteins by 64%. Biological transformation occurs in the hepatic system. Folic acid is derived renal system, in part through the intestines.
Indications
Completion of a lack of iron in the body in:
- anemia ;
- pregnancy ;
- heavy bleeding ;
- unbalanced diet ;
- impaired iron absorption in the digestive tract.
Contraindications
- hemosiderosis (excess Fe in the body);
- obstruction of the digestive tract;
- sideroahresticheskaya anemia ;
- anemia of lead poisoning;
- Specific anemia (megaloblastic, hemolytic, isolated lack of vitamin B12);
- Individual hypersensitivity ;
- stenosis of the esophageal opening;
- age limit - 18 years.
Side effects
The most common adverse reactions are recorded by the digestive tract:
- violations of the chair;
- flatulence ;
- epigastric discomfort;
- nausea;
- discoloration of feces;
- vomiting.
Less marked darkening of the tooth enamel because of the aggressive action of iron, allergic responses ( temperature rise . itch . bronchospasm ). In rare cases, anaphylactic reactions are recorded, hot flushes, weakness, fatigue. Long-term treatment leads to the development of hemosiderosis.
Instruction in Guinot-Tardiferon (method and dosage)
The drug is taken per os. The preferred time - before meals. Recommended drink sufficient volume of liquid water.
To prevent appoint 1 tablet, the multiplicity - every 24 hours. For the treatment prescribed 1 tablet twice per day. Duration of antianemic therapy is determined individually, assessing the severity of the anemia, the effectiveness of therapy, comorbidities, treatment tolerability. After normalization of hemoglobin is not recommended to discontinue therapy. The average duration of treatment of anemia - about 3 months after stabilization of laboratory parameters.
Overdose
Admission sredneterapevticheskih doses can lead to an overdose. The main symptoms: vomiting reflex, nausea; possible death on the background collapse . Lethal dose - 180-300 mg per 1 kg. In the first hours of poisoning celebrated cold sweats, confusion, frequent stools, vomiting blood, drowsiness , Cyanotic skin, melena, shock, heart, drop blood pressure until Tuesday. In some cases the symptoms are recorded hyperventilation , Convulsions, nekrotizirovanie mucous membranes of the digestive system.
Apparent improvement may occur after 4-6 hours, but 12 hours later develop severe clinical picture of shock with displays coagulopathy and liver failure. First aid may consist in the use of milk, raw eggs, which will slow down the absorption of iron by binding with it. Effectively timely gastric lavage carbonate Na, and co-administration of saline laxative.
When explicit overdose prescribe Deferoxamine : 5-10 grams per os (dissolved in water ampoules 10-20). Can be administered parenterally 1-2 gram intramuscularly every 3-12 hours. Acceptable use of infusion - intravenous infusion of 1 gram of the medicament. It is recommended that posindromnuyu therapy. Hemodialysis and peritoneal dialysis found to be effective.
Cooperation
Iron is able to slow the absorption of zinc and Thyroxine . If concurrent therapy is marked malabsorption penicillamine, carbidopa, levodopa, ciprofloxacin. Cholestyramine, antacids, magnesium and calcium, slow down the absorption of iron. The opposite effect is observed at the reception vitamin C . citric acid . Irritation of the medicament is enhanced when taking NSAIDs. It slows down the absorption of iron in the background of chloramphenicol. Recommended withstand hour window between taking the drugs. Antimicrobial agents ( Penicillin . Tetracycline ) Are able to create enough stable complexes with sulfate Fe, which significantly impairs the absorption of iron.
Stimulation erythropoiesis enhanced by treatment with glucocorticosteroids. The pharmacological activity of the drug is reduced when taking Vitamin E . The majority antimicrobials , Antacids, analgesics, sulfonamides, antiseizure medications impair the absorption of folic acid.
Terms of sale
Gyno-Tardiferon can be purchased without a prescription.
Storage conditions
Limit children's admission. Temperature - 25 degrees Celsius.
Shelf life
5 years.
Cautions
Against the background of antianemic treatment may be exacerbated rheumatoid arthritis . Recommended regular haematological monitoring of blood parameters. In patients with diabetes important to note that the preparation contains sucrose . The drug has no effect on the ability to manage complex mechanisms.
Analogs
Ferretab
Foul Maltofer
- Ferretab
- Aktiferrin
- Maltofer
- Ferrum Lek
Gyno-Tardiferon during pregnancy and lactation
The drug is approved for use in pregnancy. In severe anemia, iron deficiency develops simultaneous tissue hypoxia in the fetus and the mother, which leads to negative consequences. Hemoglobin is actively involved in the transport of oxygen, its binding and transport.
With a lack of folic acid increases teratogenic risk , Worsens the prognosis of pregnancy and impaired fetal development. When sufficient folic acid is a full-fledged formation of the nervous system of the fetus, normally developed all the organs and tissues. Iron is capable excreted in breast milk in low concentrations.
Reviews of Gino-tardiferon
Basically its report on the preparation of thematic forums leave expectant mothers. Reviews Positive Pregnancy: medication is well tolerated and quickly compensates for the deficiency of hemoglobin and iron, which is confirmed by laboratory tests. Among the negative reactions future mothers say constipation Darkening chair and dental enamel.
Price Guinot-tardiferon where to buy
Price medication in Ukraine is 115 UAH, Russia - 160 rubles.
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