Pangrol

Description overdue on 02/09/2014

• Latin name: Pangrol
• ATC code: A09AA02
• Active substance: Pancreatin (Pancreatin)
• Manufacturer: Berlin-Chemie AG / Menarini Group (Germany)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Pangrola 10000 (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

In one enteric capsule preparation Pangrol 10000   contains mini-tablets covered with a special membrane, as part of the core containing 153 mg 5. of the active component, either pancreatin.

In addition to the drug present in the composition of such ancillary items as: magnesium stearate   (0, 84 mg.)   Croscarmellose sodium   (5, 1 mg.), hydrogenated castor oil   (1, 7 mg.), colloidal anhydrous silicon dioxide   (0, 84 mg.) And microcellulose   (8, 5 mg.).

The shell of enteric minitablets contained in capsules Pangrola 10000 It consists of a mixture of compounds such as: talc   (5 mg.), 30% ethyl acrylate copolymer dispersion and   methacrylic acid   in a ratio of 1: 1 (25 mg.) triethylcitrate   (2, 5 mg.), 30% simethicone emulsion as dry weight   (0, 01 mg.).

The composition of the body and cap of the capsule consists of the following chemicals: gelatin, titanium dioxide and dyes such as the indigo carmine, Yellow and red iron oxide, and   E104   ( quinoline yellow ).

The chemical composition of a single enteric capsules Pangrol 25000 contains mini-tablet with 356 mg of 1. pancreatin. AT drug core composition contains auxiliary components such as: microcellulose   (19, 7 mg.), sodium croscarmellose (11, 8 mg.) silica   (1, 97 mg.) magnesium stearate   (1, 97 mg.) And hydrogenated castor oil   (3, 96 mg.).

Sheath minitablets is a mixture of the following components: talc   (11, 6 mg.) 30% copolymer dispersion   (in the ratio 1: 1) methacrylic acid and ethyl acrylate (57: 9 mg.) triethylcitrate   (5, 8 mg.) 30% dry simethicone emulsion   (0, 03 mg.).

As part of the lid and body enteric capsules Pangrol 25000   contains the following components: titanium dioxide, gelatin and dyes   ( indigo carmine, iron oxide   yellow and red, as well as   quinoline yellow ).

As part of a single tablet Pangrola 20000   contains pancreatin And lactulose monohydrate, microcrystalline cellulose (MCC), crospovidone, silicon dioxide, magnesium stearate, a copolymer of methacrylic acid and ethyl acrylate, methylhydroxypropylcellulose, simethicone emulsion, talc, Macrogol 6000, polysorbate 80 and sodium carboxymethylcellulose.

Composition three dosage forms of the drug capsules Pangrol 10000 . Pangrol 25000 And tablets Pangrol 20000   different rates of minimum activity of such active compound components of the active compound such as: Protease   (500 IU, 1250 IU and 900 IU) lipase   (10,000 IU, 25,000 IU and 20,000 IU), and amylase   (9000 IU, 22500 IU, and 12).

Product form

Pangrol 10000   and 25000   release capsules (opaque, gelatin, solid) and №0 number 2, respectively, which are cylindrical in shape. Capsule body distinguished by its bright orange, and the capsule lid - yellow-green tint. The contents of the capsules of the drug is a mini-tablet, which also have a cylindrical shape, characterized by a light beige color enteric coating and shiny surface.

As a rule, in carton Pangrola 10000   and   25000   It comprises a polypropylene bottle, which may be 20, 50 or 100 capsules. Pangrol 20000   represent oboevypuklye enteric coated tablets dosage shell having a smooth surface and different gray-white color. Tablets are packaged in blisters and placed in cartons of 20 or 50 pieces.

Pharmacological action

The drug belongs to the group of digestive-enzyme drugs. Pangrol helps fill enzyme deficiency Required for normal operation pancreas And it has on the human body proteolytic, lipolytic , and Amilolitichesky impact .

Pharmacodynamics and pharmacokinetics

Pancreatin   or pharmaceutically active substance contained in the composition Pangrola is a powder, which is obtained in the processing of porcine pancreas. Contained in the powder enzymes   a positive effect on the process digestion and accelerate the breakdown of fats, carbohydrates and proteins, and, moreover, helps in the normalization of pancreas .

Due to the fact that the drug promotes complete digestion of food, medicine relieves the symptoms of digestive disorders such as shortness of breath, arising due to flatulence and fullness, feeling of heaviness and pain in the abdomen, as well as flatulence . The drug stimulates pancreas, small intestine and stomach on the development of human enzymes Involved in the digestive process.

The extract bile , Part of the increases Pangrola emulsification of fats   and acts on the organism choleretic Ie increases activity lipase Thereby improving digestion and absorption of fat soluble essential stomach vitamins E, A and K And fats entering the body with food.

Capsules and tablets are coated Pangrola specialized acid-resistant shell that helps protect the drug from gastric   prior to contact with the drug in small intestine . Capsule shell rapidly dissolves and releases the mini-tablets containing enzymes   which, in turn, are mixed with the contents of the intestine, thus ensuring a necessary level enzymes   and their uniform distribution.

For effective medicinal action of the preparation is important to keep in small intestine   neutral to slightly alkaline pH value . Pangrol of the digestive tract is not absorbed and excreted in the feces.

Indications

Pangrol used as replacement therapeutic treatment of both adults and children in the violation of exocrine pancreas And at a relative enzyme deficiency Caused by diseases such as:

• pancreatic cancer   or narrowing of the duct, combined with the presence of gallstones   or cancer ;
• pancreatitis Including preostrye or chronic stage of the disease;
• Diamond syndrome Shvahmana ;
• intestinal infections ;
• Irritable Bowel Syndrome ;
• disorders of the digestive tract   functional character;
• mukovistsido s .

Everything else, the drug used to prepare for an ultrasound or X-ray study abdomen And to restore normal operation of the pancreas and stomach after surgery, for example after   resection or as part of a therapeutic treatment after irradiation in the presence of symptoms such as diarrhea, no digestion and flatulence .

Contraindications

Pangrol is contraindicated in:

• acute pancreatitis ;
• hypersensitivity   the components of the drug;
• exacerbation of pancreatitis .

Side effects

During the administration of the drug may cause side effects such as:   nausea, bloating and vomiting , and diarrhea, abdominal pain and others disorders of the digestive system . Quite rarely, patients have the appearance of allergic reactions   on Pangrol, which is usually expressed in appearance itching, hives or rash on the skin . If you find the above ailments should stop using the medication and seek medical advice.

Instructions for use Pangrola 10000 (method and dosage)

Capsules and tablets Pangrola take food without chewing and swallowing whole with liquid, preferably normal room temperature water. Dosage determined by a physician and depends on the condition of the patient, the severity of the disease and shape. For preparation in capsules The following average therapeutic doses of:

• adults - 2-4 or 1-2 capsules Pangrol 10000   and 25000   respectively;
• children - an estimated 500-1000 lipase units per kg at every meal.

In accordance with the instruction for Pangrol 20000   Tablets take 1-2 pieces. during direct ingestion. The average therapeutic dose may vary depending on the disease, and also depends on the food, which is included in the diet of the patient. The doctor can increase the daily dosage of the drug containing in its chemical composition Digestive enzymes   within the maximum allowable 15,000-20,000 units lipase   per kilogram.

The duration of treatment depends on the severity and type of disease, and the condition of the patient. If a patient can not accept a whole independently capsule Pangrola (elderly or children), it is possible to pour out its contents (mini-tablets) in a liquid such as water or mixed with food, which requires no mastication (fruit puree). A mixture of food and mini-tablets should be taken immediately and not allowed to store.

When treating Cystic Fibrosis   the dosage depends on the patient's body weight.

Pangrola Initial dosage for children under 4 years of age is 1,000 units lipase   per kg, and for children older than 4 years - 500 units. During the use of the drug in the therapeutic treatment of children should be required to follow a diet to exclude development   steatorrhea .

Overdose

About overdosing and increase the number of enzymes in the treatment of Cystic Fibrosis   may indicate diseases such as hyperuricemia , and hyperuricosuria .

Cooperation

About Pangrola drug interactions with other medications are no reliable data.

Terms of sale

OTC.

Storage conditions

Keep out of the reach of children, at a temperature not exceeding 25 ° C.

Shelf life

• 2 years for capsules Pangrol 10000   and 25000 ;
• 3 years for tablets Pangrol 20000 .

Cautions

When treating Cystic Fibrosis   in patients treated with high doses of the drug may occur fibrosing colonopathy Ie stricture of the ileum, colon and cecum . To avoid changes in the symptoms of the underlying disease to the direct reception Pangrola should conduct medical research that will eliminate the presence of the patient lesions of the colon .

The drug does not affect the ability to drive and does not reduce the rate of reaction when working with potentially dangerous machinery.

Analogs Pangrola 10000

Match code ATC 4th level:

• Mikrazim
• Enzistal P
• Pancreatin
• Penzital
• Ermital
• Creon
• Abomin
• Festal
• Mezim

The main structural analogues of the drug can be considered the following drugs:

• Gastenorm Forte;
• Creon 10000, 25000 and 40000 ;
• Mezim ;
• Mikrazim ;
• Mezim Forte ;
• Panzica ;
• Panzinorm ;
• Pancreatin ;
• Panzinorm Forte ;
• Panzi Forte ;
• Pancreatin-Lect ;
• Pantsitrat ;
• Festal ;
• Pancreatin Forte ;
• Penzital ;
• Enzistal-P ;
• Pancrelipase ;
• Ermital .

Pangrol 10,000 children

Mode dose, duration of treatment and the dosage is determined by the doctor depending on the child's age, health status and disease severity.

During pregnancy and lactation

Although pregnancy and breast-feeding   not included in the list of absolute contraindications to the use of Pangrola reliable results of clinical studies aimed at identifying the effects of   pancreatin   fetal development, no. Because testing pancreatic enzymes   pigs was carried out on animals and was successful, experts exclude the possibility of toxic effects of the drug on the development of the unborn child.

However, the use of Pangrola during pregnancy is possible only in the absence of contraindications, and is justified only if the anticipated benefits of the drug outweigh the possible negative consequences. When breastfeeding is allowed to take this drug.

Reviews on Pangrol 10000

In most cases, patients taking leave positive feedback Pangrole.

The only downside of the drug many consider the complexity of a dosage. As digestive problems are purely individual character, to choose the correct dose of the drug can be a doctor, making it difficult to independently use drugs.

Price Pangrola where to buy

The cost of the drug depends on the formulation of the issue. For example, packaging Pangrol 20000   (50 tablets) can be purchased at an average of 1,000 rubles.

Cost Pangrola 10000   (packaging, 20 caps) on average no more than 250 rubles.

Average price Pangrola 25000   (packing, 20 capsules) is 1000 rubles.

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