Cold Kaffetin

Description overdue on 10/16/2014

• Latin name:
• ATC code:
• Active substance: + Dextromethorphan + Paracetamol Pseudoephedrine + Ascorbic acid (Dextromethorphan + Paracetamol + Pseudoephedrine + Ascorbic acid)
• Manufacturer: Alkaloid AD, Republic of Macedonia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Reviews
• Price, where to buy

Composition Kaffetin Cold

Kaffetin Cold as active substance in each tablet contains:

• 500-555 mg paracetamol   (in the form of granules, which consist of 90% paracetamol And auxiliary substances: 8, 4% prozhelatinizirovanogo starch, 0, 6% povidone, 1% stearic acid);
• 30 mg pseudoephedrine hydrochloride ;
• dextromethorphan hydrobromide ;
• 60-62 mg   ascorbic acid   (used granulate which comprises 97% ascorbic acid and 3% hydroxypropyl methylcellulose).

The film coating is made from Opadry II blue (E132 - indigo carmine), macrogol, polyvinyl alcohol (partially hydrolyzed), titanium dioxide (E171) and talc.

Product form

Cold Kaffetin drug is available as blue, oblong, biconvex, film-coated tablets, each tablet on one side there is the risk.

Every 10 tablets are placed in a perforated blister, which includes aluminum foil and transparent three-layer film. Blisters on 1 piece laid out in cardboard boxes.

Pharmacological action

Cold has Kaffetin antitussive   and analgesic   action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The action of the drug due to the combined effect of the components of the preparation:

• Paracetamol   causes analgesic   and pyretic   action. It blocks cyclooxygenase   in the central nervous system by acting on the thermoregulatory centers and pain. A distinctive feature of paracetamol NSAIDs a virtually complete absence of anti-inflammatory effect. It does not irritate the mucous membrane of the stomach and intestine and does not affect the flow water-salt metabolism Because it does not affect the synthesis of prostoglandinov   in peripheral tissues.
• Pseudoephedrine edema , Thereby reducing nasal secretion and nasal breathing is facilitated.
• Dextromethorphan   cough threshold Thereby reduces dry cough, which is connected to a cold irritation of the nasal mucosa and pharynx.
  Ascorbic acid   - Restores the lack of vitamin C, which is often observed during colds.

Pharmacokinetics

A significant part paracetamol   absorbed in the small intestine, and the maximum plasma concentration   It is achieved in a period of half an hour to one and a half hours after oral administration.
Metabolism of paracetamol (about 90-95%) in the liver: 80% inactive metabolites substance formed by the reaction of conjugation with glucuronic acid and sulfate, and 17% hydroxylated form active substances 8-metabolites, which then occurs conjugation reaction with glutathione in

In case of lack of glutathione metabolites formed may have a blocking effect on the enzyme systems of the liver cells and induce their death. Also participates in the metabolism isoenzyme CYP2E1 . The half of the body is from 1 to 4 hours. Displayed preparation kidneys as metabolites, mainly in the form of conjugates, of which only about 3% are output unchanged. In old age may be reduced drug clearance   and an increase in half-life.

Pseudoephedrine   is rapidly absorbed after administration of the tablets inside, the maximum plasma concentration is reached within 1, 5-2 hours. The half-life of plasma   5 is approximately 5 hours. Metabolism   partly it occurs in the liver - formed active metabolite, which is then excreted from the body in urine.

Absorption dextromethorphan   after it was taken up it occurs quickly, and the maximum blood concentration occurs in about 2 hours after taking the tablets. Metabolism dextromethorphan   Metabolite excreted in the urine unchanged and as metabolites.
Ascorbic acid   absorbed in the gastro-intestinal tract and is rapidly distributed to the tissues. It is oxidized to degidroksiaskorbinovoy acid   (reversible), and some amount of ascorbic acid, In the body, is metabolized into a substance ascorbate-2-sulfate . Excreted ascorbic acid is eliminated in the urine.

Indications

Used for the symptomatic treatment of colds and Flu   (in the presence of headache

Contraindications

• hypersensitivity   to the drug or to any of its components;
• diagnosis hypertension . coronary heart disease   or angina ;
• severe liver or kidney disease, as well as hepatitis ;
• simultaneous use monoamine oxidase inhibitors . Antidepressants , Drugs used in antiparkinsonian therapy   or application monoamine oxidase inhibitors   in the last 2 weeks prior to receiving Kaffetina Kolda;
• congenital deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy ;
• ;
• age less than 12 years.

Caution must be exercised in taking the drug at:

• benign hyperbilirubinemia   (including the Gilbert's syndrome );
• ;
• alcoholism ;
• Arrhythmia ;
• prostatic hyperplasia   (especially if this occurs urinary retention);
• diabetes ;
• hyperthyroidism ;
• asthma ;
• chronic obstructive pulmonary disease ;
• general exhaustion.

Side effects

Side effects of the drug may show different symptoms from virtually all body systems:

• epigastric ; in case of prolonged use of large doses is shown hepatotoxic effects preparation;
• central nervous system - the side effects of the drug is sleepiness , Irritability, agitation; in some cases - dizziness ;
• can be observed   allergic reactions   in the form of skin rashes, pruritus . hives . angioedema ;
• cardiovascular system - sometimes rises arterial pressure , You may receive tachycardia ;
• Forming Organs - occasionally observed development anemia, thrombocytopenia, agranulocytosis,   If the drug is taken for a long time and in large amounts increases the likelihood of developing hemolytic anemia, aplastic anemia, pancytopenia ;
• urinary system - at long term use of the drug in large quantities has Kaffetin nephrotoxicity Which can be shown renal colic , Development interstitial nephritis . papillary necrosis ).

Instructions for use (method and dosage)

Kaffetin Cold intended for ingestion.

Allowed reception and 2 tablets at a time. The interval between doses should not be not less than 4 hours. A single dose should not exceed 2 tablets per day dose should not exceed 8 tablets.

If the temperature is increased more than 3 days from the start of drug administration, and the cough does not go within 5 days, you need to seek medical help.

Overdose

In case of overdose there is cause nausea, ringing in the ears, pain in the stomach rises sweating Skin becomes pale, quickens heartbeat .

In case of overdose the stomach should be washed. Then, should enact weight dose Activated Carbon . If necessary, you need to spend symptomatic therapy.

Cooperation

Simultaneous use paracetamol   large doses enhances the action anticoagulant drugs.

Supplementation relating to Which occurs in the liver ( phenytoin Ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants ) And hepatotoxic drugs increases the formation of hydroxylated active metabolic product of paracetamol, which determines the probability of occurrence   severe intoxication   Even when taking a small dose of the drug.

barbiturates   reduces the effect of admission paracetamol .

Combining Reception paracetamol   in large quantities and salicylates   (especially cases of prolonged simultaneous use) increases the likelihood of Cancer  

Prolonged use of paracetamol and co NSAIDs   increases the risk of analgesic nephropathy   or renal papillary necrosis Noticeably closer the time of the end-stage of development renal failure .

Receiving diflunisal Which has the property to increase the plasma concentration half, resulting in increased risk of   hepatotoxic action drug.

The simultaneous use pseudoephedrine   and other may cause additive effect The combination pseudoephedrine   from monoamine oxidase inhibitors   It can lead to hypertensive crisis . Therefore, use of the drug is allowed no earlier than two weeks after it was discontinued reception monoamine oxidase inhibitors .

Simultaneous reception propranolol   can strengthen pressor effect Exerted pseudoephedrine . Also, in the use of pseudoephedrine may decrease hypotensive action   such as the drugs R ezerpin, methyldopa, mecamylamine and hellebore alkaloids .

Preparations F luoksetin, Amiodarone and quinidine   cytochrome P450 system Thereby creating the conditions for increasing the concentration   dextromethorphan   in the circulating blood.

Terms of sale

Sold under a prescription.

Storage conditions

It should be stored at a temperature not exceeding 25 ° C.

Shelf life

Pass for 2 years.

Cautions

At the time of the drug must be ensured peripheral blood With the functional state of the liver.

During the treatment period, forbidden to drink ethanol   (can lead to liver toxicity of the drug), and caffeine-containing foods and drugs.

The drug affects a person's ability to drive vehicles and to engage in any other types of activities that require concentration, speed of psychomotor reactions.

Reviews

Reviews on the use of the drug a little bit. The tablets have a significant effect, but care should be taken, to take the drug strictly according to instructions. Important lack of patient conditions that are contraindications for the use of the drug.

Price, where to buy

Cold Kaffetin drug can be bought in almost any drugstore. The price is about 160 rubles.

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