Neyromultivit

Description overdue on 11/30/2014

• Latin name: Neuromultivit
• ATC code: A11AB
• Active substance: Pyridoxine (Pyridoxinum), cyanocobalamin (Cyanocobalaminum), thiamine (Thiaminum).
• Manufacturer: G.L.PHARMA, GmbH, Austria

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Neyromultivita
• Contraindications
• Side effects
• Medicine Neyromultivit: instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Neyromultivit children
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition Neyromultivita

The structure Neyromultivita (one film-coated tablets) contains 0, 1 g Vitamin B1   (thiamine hydrochloride; Thiamine hydrochloride), 0, 2 g vitamin B6   (pyridoxine hydrochloride; Pyridoxine hydrochloride), 0, 2 mg B12 (cyanocobalamin; Cyanocobalamin), and a number of auxiliary substances:

• microcrystallic cellulose (Cellulosum microcristallicum);
• Magnesium Stearate (Magnesium stearate);
• povidone (Povidonum).

In composition of the covering a pill shell includes:

• macrogol 6000 (Macrogol -6000);
• Titanium dioxide (Titanium dioxide);
• Talc (Talcum);
• Valium (Hypromellose);
• copolymers of methacrylic acid methyl ester (methyl methacrylate) and ethyl acrylate (ethyl acrylate) in a ratio of 1: 2 (in the form of a dispersion with a 30% concentration).

Product form

Formulation Neyromultivita - biconvex round shaped film coated. Sheath color white or almost white. When cut the color of the tablet varies from white to light pink with a splash of light to dark pink color.

The pharmacy pill comes packed with 20 pieces in blister, single blister is in a carton box.

Pharmacological action

The drug belongs to the pharmacotherapeutic group " Vitamins and vitamin-like agents in combination ". Its action is aimed at stimulate metabolism in the CNS and nerve regeneration .

In addition, its active components - vitamins B1, B6 and B12   - Have analgesic influence , That the allows to use them not only for treatment with vitamin-deficient states But also for the treatment of diseases that are not related to vitamin deficiency or violation metabolism   (eg, pain . psychoses . carpal tunnel syndrome . polyneuritis . mononeuropathies   etc.).

Like other vitamins . B vitamins   - It is essential nutrients, which are formed directly in the body.

Administering a drug vitamins B1, B6 and B12   It allows you to compensate for vitamin deficiency, caused by vitamin deficiency   in the food, and provides the presence in the body required amount coenzymes .

Therapeutic use B vitamins   for different injuries H C is necessary, on the one hand, to compensate for the existing vitamin deficit (which may be due to the increased demand of the body due to disease) and, on the other - to stimulate the natural repair mechanisms.

Combined preparation Neyromultivit contains in its composition neurotrophic active substances B vitamins Which act as coenzymes   in place in central and peripheral NA (nervous system) processes intermediate metabolism .

Active ingredients are characterized as Neyromultivita low-toxic substances So the drug is not associated with a potential risk to humans.

Pharmacodynamics and pharmacokinetics

Exogenous Vitamin B1   by phosphorylation biotransformed in humans cocarboxylase, coenzyme which is a large number of enzymatic reactions and processes catalyzed carboxylation and decarboxylation of alpha-keto acids.

Thiamine   It plays an important role in the regulation carbohydrate, lipid,   and   protein metabolism . In addition, he is actively involved in the processes of neural excitation in synapses .

Action vitamin B6   ( pyridoxine ) Is directed at maintaining normal function peripheral and central NA . The phosphorylated form he is participating in the metabolism of amino acids coenzyme (in particular involved in transamination reactions and decarboxylation).

Pyridoxine   It acts as a coenzyme operating neural tissues   and it is important for the body enzymes And is also involved in the biosynthesis of amino acids of biogenic amines (neurotransmitters). With his participation to synthesize GABA (Namma-aminobutyric acid) adrenaline . histamine . dopamine . norepinephrine .

Cyanocobalamine   is required to maintain hematopoiesis functions In particular it is required for the normal maturation erythrocyte . Cyanocobalamin   is also involved in a number of biochemical reactions, thus ensuring a vital activity as a whole: in the methylation reaction (transfer of methyl groups by SAM for specific regions of DNA), the exchange of amino acids . carbohydrate and lipid metabolism In the synthesis of nucleic acids and proteins .

It also acts on the processes occurring in the NA (in particular, the synthesis of RNA   and DNA ), Lipid composition of cerebroside   (glycosphingolipids) and phospholipids . Methylcobalamin and adenosyl cobalamin that are coenzyme forms B12 , Play an important role in processes replication and growth cells.

B1, B6 and B12   - this water soluble vitamins , So in the body, they do not cumulate. Absorption thiamine   and pyridoxine   It occurs the upper part of the intestinal tract , The degree of dose-dependent.

Absorption and distribution in the body cyanocobalamin   It is determined mainly by the presence of internal factors in stomach and upper gastrointestinal tract .

All active components are metabolized in Neyromultivita   liver .

Derivation function thiamine   and pyridoxine   carried kidney (8 to 10% of these substances is eliminated in unmodified form). Moreover in case of overdose increases substantially excretion of of these substances through the intestines.

Cyanocobalamine   excreted mainly with bile , The degree of removal of substance kidney   is variable and ranges from 6 to 30%.

Indications Neyromultivita

The drug used in neurologic practice as a component of complex therapy. Indications for use of Neyromultivita are:

• trigeminal neuralgia ;
• polyneuritis   of various genesis (including inter alia diabetic and alcoholic polyneuropathy );
• neuritis   (inflammatory disease of the peripheral nerves);
• intercostal neuralgia ;
• ischialgia   (sciatic nerve damage caused by its inflammation or compression) lumbago (lumbar syndrome or lumbar backache, the main symptom of which is a sharp pain in the lower back) and sciatica ;
• plexitis (shoulder, lumbosacral or cervical);
• radicular syndrome   (radiculopathy), developed on the background degenerative diseases of the spine ;
• neuropathy facial nerve a   (including but not limited Bell's palsy   and prozoplegiyu ).

Contraindications

The drug is contraindicated in people sensitive to its components, as well as children under 12 years. Additional contraindications are:

• allergic nature of the disease   (for   Vitamin B1 );
• aggravated gastric ulcer and duodenal ulcer   (for vitamin B6 ; welcome it if this disease can cause gastric hyperacidity);
• erythremia   ( disease Vakeza ) polycythemia . embolism   (occlusion) of a blood vessel by a thrombus bed (for B12 ).

Side effects

In general, Neyromultivit sufficiently well tolerated. However, there were cases when treatment with their patients developed tachycardia , Noted nausea   and emerging allergic reactions , Expressed mainly in the form of rashes on the skin and itching.

When those or other unwanted effects, stop taking the tablets and consult your doctor.

Medicine Neyromultivit: instructions for use

How to accept Neyromultivit?

Neyromultivit for perooralnogo reception. Damage to the integrity of the coating film, which is coated pills, can cause disturbances pharmacokinetic profile of the drug. For this reason it is recommended that pre-milled or chewable tablets.

To achieve maximum therapeutic effect, Neyromultivit should be taken immediately after meals. Wash down the tablets of ordinary drinking water.

The duration of treatment and the dose determined by the physician.

Instructions for use Neyromultivita: dosing regimen

Depending on the condition of the patient, the severity of symptoms and concomitant therapy take one tablet with a multiplicity of methods 1 to 3 times per day.

In elevated a dosage of a medicine should be to accept not longer than 4 weeks in a row.

Babies instructions for use permits reception Neyromultivita only when they reach the age of twelve.

Overdose

The drug in doses exceeding recommended by the manufacturer, provokes increased risk of unwanted side effects.

Specific antidote Neyromultivita have not. If you suspect an overdose, discontinue use of the drug. In cases where there is a need, symptomatic treatment.

Cooperation

5-fluorouracil   inactivates the action thiamine . This effect is due to the ability to 5-fluorouracil   competitively inhibit the phosphorylation of the latter in kokarboksilazu.

Together with the application antatsidnymi means   is deteriorating the absorption of thiamine .

Long-term treatment with loop diuretics   (u, in particular, Furosemide ) That have an inhibitory effect on tubular reabsorption may increase elimination of thiamine   from the body and thus lower the quality.

Against the backdrop of the simultaneous reception with Neyromultivita pyridoxine antagonists   (eg, anti means Isoniazid   and Cycloserine Detoxifying agent penicillamine , Vasodilator hydralazine ) And oral contraceptives   increased demand Vitamin B6 .

In the case of simultaneous application vitamin B6   with the preparation of anti- Levodopa effectiveness of the latter may be reduced.

Terms of sale

The drug belongs to a group of prescription drugs.

Storage conditions

Neyromultivit Store in a dry, dark place. Keep away from children. The temperature should not exceed 25 degrees. Celsius.

Shelf life

Pass to the application within 36 months from the date of issue.

Cautions

The treatment Neyromultivitom in high dosage should not exceed four weeks. Otherwise, at high risk for neurologic .

Absorption thiamine   decreases while its use with alcoholic drinks and black tea. Under the influence contained in some beverages (e.g. wine) sulfites enhanced degradation thiamine .

Due to the fact that the drug contains vitamin B6, patients with gastric ulcer and duodenal ulcer   history, and with the express renal dysfunction   and / or liver   Neyromultivit be used with caution.

Patients with funicular myelosis   (combined degeneration) or pernicious anemia (B12-deficiency anemia) due to the application of B12   clinical picture and laboratory results can lose their specificity.

Patients whose tumors were detected, except in cases involving deficiency B12   and megaloblastic anemia Should not be treated with the drug.

Neyromultivit also used to treat patients with angina   and patients with severe forms of acute or decompensation Heart Failure .

Analogs Neyromultivita

Match code ATC 4th level:

• Revalid
• Gerimaks
• Biovital
• Vitrum Vision
• Vitrum Beauty

Neyromultivita structural analogues (generics) - a drug Angiovit   and Multi-tabs The Complex .

Similar preparations of the mechanism of action - a brewer's yeast autolysate cleaned (in the form of powder for oral suspension), lyophilisate for injection Bevipleks . Pentavit . Yeast brewer's peeled dry   (in the form of a powder for suspension), film-coated tablets Intensive Multi-tabs B solution in / and the / m Medivitan .

Price starts from the unique 100 UAH.

What is better - or Neyromultivit Pentovit?

The main difference between drugs - it is their composition. If Neyromultivit - a combination vitamins B1, B6 and B12 , In addition to them Pentovita composition also includes nicotinamide   ( vitamin PP ) And folic acid   ( Vitamin B9 ).

Accordingly, the range of pharmacological effects in a somewhat broader. Vitamin B9   is required for normal maturation megaloblasts In addition, it stimulates the production of erythrocyte   at bone marrow Takes part in exchange of choline   and purine synthesis . pyrimidine . nucleic acid . amino acids .

Nicotinamide   participates in place in living cells oxidative reactions and provides hypocholesteremic . vazodilatirtee   and gipolipidemicescoe   action.

Both drugs are used to treat Central nervous system . However Neyromultivit is more expensive than its counterpart.

Neyromultivit for the children

According to the instructions, Neyromultivit contraindicated in children under 12 years. This is connected with lack of data about the safety of and therapeutic effectiveness of the drug for the given group patients. However, the drug is often used in pediatric practice.

Reviews physicians suggest that the drug is given not earlier than one year of age, since the content vitamins   it significantly exceeds the daily needs of the child in them about ten times.

Thus, giving the infant or child up to a year the drug can provoke him supervitaminosis .

In cases where an alternative therapy Neyromultivitom no decision on the appointment of the drug to children under one year should be made only after a thorough examination of the child and anamnesis.

From what Neyromultivit pills prescribed to children?

Neyromultivit takes an active part in leaking at the cellular level the processes of metabolism , Restoring when this its functions and improving Item condition NA .

Vitamin B6   It is extremely important for the child's mind as an indispensable source of energy for children: it is involved in   metabolism of amino acids . the synthesis of neurotransmitters As well as transmission of nerve impulses . Cyanocobalamin   It contributes to a better saturation of the tissues and organs of the child with oxygen.

Neyromultivit appoint:

• at elevated neuropsychiatric and physical activity;
• defective and malnourished children;
• when different kinds neuralgia .

The dosage for children Neyromultivita

The recommended dose for children Neyromultivita - three pills a day, one at the reception three times daily after meals. The drug is recommended to drink a small amount of liquid.

If the drug is prescribed the child up to a year, a single dose of are cutting to 0, 25 pills with multiplicity of applications two times a day. In those cases, if the child is too small and not able to swallow the tablet, it may be crushed in a spoon and mix with formula or breast milk.

How to to adult patients, to children take the drug allowed not to longer than in within four weeks. Otherwise, the child increases the risk of neurological complications of type.

Do not give medicine to a child just before bedtime, as it can improve excitability of the central nervous system , May be a consequence of which insomnia   the baby.

Reception if pregnancy and lactation

Pregnant and lactating women Neyromultivit recommended.

Reviews Neyromultivit

Reviews Neyromultivit forums you can find a wide variety. The majority of patients report that treatment of severe pathologies   using only Neyromultivita alone will not give a positive result, it is better - as is recommended by guide - prescribed the drug in the complex therapy.

The main mass of of positive of reviews about the Neyromultivit is left people are, to use This tool for the prevention hypovitaminosis   and elimination of the consequences of mental, emotional and physical overload.

Almost every such withdrawal marked efficacy in hair loss, problems with nails and fatigue. Athletes also taking these   vitamins , Much faster restore forces after tedious workouts.

Reviews Neyromultivit children indicate that the drug improves work NA , Relieves irritation, eliminates neuroses It improves memory and promotes better assimilation of the material. However, many mothers say unpleasant odor tablets, because of which the child takes the medicine with great displeasure.

Price Neyromultivita

Price Neyromultivita in Ukraine

In the Ukrainian pharmacies, the average cost of the drug - 63-65 UAH.

Price tablets Neyromultivit in Russia

In drugstores Russia buy a vitamins can be for 160 rubles.

Get the best price and buy