Prothionamide

Description overdue on 25.05.2012

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Anti-TB drugs.   Active substance emionamidu close to their chemical structure. The mechanism of action is based on blocking the process of synthesizing mikolievyh acids , Which represent essential component of structure of cell wall causative agent of tuberculosis - mycobacteria. Prothionamide possess antagonist properties of nicotinic acid. High doses of the drug can interfere with the process of synthesizing a protein in a cell mycobacteria. The drug is bacteriostatic influence against intracellular microorganisms extracellularly located on breeding Mycobacterium tuberculosis, including drug influences the atypical forms. Complete cross-resistance observed between the drugs and protionamid ethionamide. The medicament is issued in the form of tablets.

Indications:

Prothionamide prescribed for tuberculosis: extrapulmonary, pulmonary form, ulcerative, infiltrative and exudative processes. The drug is prescribed for sustainability microflora to first-line anti-TB facilities, as well as registration of their poor tolerability.

Contraindications:

Prothionamide do not appoint at pregnancy, acute form of gastritis, cirrhosis , Of peptic ulcer disease the digestive system, when ulcerative colitis . In severe renal pathology system in diabetes   Prothionamide used with caution.

Side effect:

Endocrine system:   gynecomastia, hypoglycemia in patients with diabetes, reduced potency, hypothyroidism . dysmenorrhea . The digestive tract:   "Metallic" taste in the mouth, diarrhea, disorders of the hepatic system, vomiting, hyperptyalism Nausea. Nervous system : Anxiety, depression, insomnia, drowsiness,   peripheral neuropathy , Paresthesia, fatigue, headache, agitation, optic neuritis. Cardiovascular system:   orthostatic form of hypotension, weakness, tachycardia. Available rashes, allergic reactions.

Mode of application:

Prothionamide taken after a meal inside. The daily dosage for adults is 0, 5-1 gram, taking in three steps. Therapy begins with 250 mg per day with gradual increase in the daily dose of 250 mg. Patients weighing less than 50 kg and the elderly over 60 years Prothionamide administered 250 mg twice a day, and the daily dose should not exceed 750 mg. The duration of therapy is designed for 8-9 months. For children the dose is calculated according to the scheme of 10-20 mg / kg per day.

Special instructions:

TB treatment drug Prothionamide begins after determining the sensitivity of microorganisms. The dose is calculated based on the tolerance and individual characteristics of the organism. Requires monthly control over the functioning of the hepatic system.

Drug Interactions:

The concentration of the drug Prothionamide increases while the body is isoniazid . The drug is compatible with TB drugs, cycloserine, pyrazinamide , Isoniazid.