Metodzhekt

Description overdue on 09/22/2014

• Latin name: Metoject
• ATC code: L01BA01
• Active substance: Methotrexate (Methotrexate)
• Manufacturer: Oncotec Pharma Produktion (Germany)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Metodzhekt (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
• Price, where to buy

Composition

Active ingredient Methotrexate   disodium; Additional ingredients:   sodium hydroxide, water for injection, sodium chloride.

Product form

Pre-filled syringes graduated to 25, 20, 15, 10, 7, 5 mg. 1 Syringe neutral colorless glass (type 1) and packed with a plastic needle in blister placed in a cardboard box.

Pharmacological action

Metodzhekt has   antitumor effect . In addition, the drug has immunosuppressive effect .

Pharmacodynamics and pharmacokinetics

Cytostatic anti-cancer drug group antimetabolites It converts dihydrofolic acid into tetrahydrofolic. Inhibits the release and restoration DNA   and cell mitosis . Its effects are especially sensitive cells bystrorazmnozhayuschiesya malignant tumors Embryonic and epithelial cells of the intestinal mucosa, urinary bladder, oral cavity. It also has an immunosuppressive action.

The plasma protein binds about half the dose of methotrexate. Time education the greatest concentration of 0, 5-1 hours. Food slows absorption of the drug. Period finite half life is about 6-7 hours, depending on the patient and the dose can vary (3-17 hours). The half-life is increased up to 4 times in patients   ascites , Pleural effusion.

About 10% of the volume is metabolized in the liver. Withdrawal takes place in most cases in an unmodified form, mainly via the kidneys. Approximately 6-21% 2-4% methotrexate and 7-gidroksimetotreksata excreted with bile . Enterohepatic circulation occurs in a distinct manner.

In renal insufficiency excretion of methotrexate significantly delayed, and information about the reasons for the delay is absent.

Indications

• polyarthritis   patients with complex shapes chronic arthritis in the active phase;
• severe psoriasis and psoriatic arthritis in adult patients, in the absence of response to conventional therapy;
• Juvenile rheumatoid arthritis .

Contraindications

• high sensitivity to methotrexate or other components of the vehicle;
• abnormal liver function;
• abuse alcohol ;
• renal insufficiency activities;
• dysfunction of the blood:   leukopenia Thrombocytopenia;
• chronic and acute infections in severe stages: tuberculosis Expressed immunodeficiency . HIV infection ;
• active phase peptic ulcer   intestines;
• pregnancy   and period breast-feeding .

Care must be taken in the following diseases:

• ascites;
• dehydration ;
• diseases associated with the obstruction of the digestive tract;
• chronic renal failure;
• diseases of viral or bacterial origin (currently or recently transferred) parasitic and infectious nature: herpes , Viremicheskaya phase herpes zoster . stomach ulcer . amebiasis , Inflammation and infection of the oral mucosa;
• vomiting, and diarrhea ;
• ulcerative lesions of the duodenum;
• old age.

Side effects

The most common and common side effects when using the drug may be noted Metodzhekt reciprocal response hematopoietic system and digestive system.

Digestive system:

• increase in transaminases;
• stomatitis;
• nausea;
• lack of appetite;

Often recorded:

• diarrhea;
• mouth ulcers .

More rarely observed:

• vomiting (possibly with blood);
• cirrhosis   and fatty change in the liver ;
• sharp hepatitis   as well as the disruption of the liver;
• erosive or ulcerative lesions of the stomach and intestinal tract;
• pancreatitis .

Hematopoietic system:

• leukopenia, and anemia;
• pancytopenia .

Very rare agranulocytosis It may develop severe bone marrow suppression.
We should also mention allergic and dermatologic reactions to Metodzhekt, including:

• rash and itching;
• baldness ;
• skin rashes and burning;
• discoloration of the nails;
• anaphylactic shock ;
• fever;
• plaques on the skin and allergic vasculitis .

Among drug reaction of the central nervous system, cardiovascular and endocrine systems emit:

• pericarditis ;
• reduction blood pressure ;
• vein thrombosis and blood vessels ;
• Headache   and fatigue;
• depression   and dysgeusia;
• drowsiness   and dizziness.

Respiratory:

• pneumonia ;
• pharyngitis ;
• pulmonary insufficiency;
• bronchial asthma .

Urinary system:

• cystitis;
• renal insufficiency;
• anuria   and painful urination.

Reproductive system:

• inflammation of the vagina;
• discharge from the vagina;
• impotence ;
• menstrual disorders, and very rarely - infertility .

Musculoskeletal system:

• osteoporosis ;
• fractures.

Metabolic:

• diabetes ;
• gipergidro s .

The reaction of the senses:

• conjunctivitis ;
• violation of visual perception;
• tinnitus .

Possible infectious lesions such as sepsis   and histoplasmosis, and neoplasms and appearance lymphomas . In applying the drug at the site of possible burning and education abscess .

Depending on the frequency of use and dose frequency and severity of side effects may vary.

Instructions on Metodzhekt (method and dosage)

The drug should be administered Metodzhekt qualified doctors who are familiar with the properties and characteristics of methotrexate. This preparation is injected subcutaneously, intravenously or intramuscularly depending on the disease and treatment characteristics 1p / week.

The composition of the package includes an injection needle designed for subcutaneous administration, in other cases used needles intended for intravenous or intramuscular administration.

Instructions on Metodzhekt: The recommended initial dose for adult patients with rheumatoid arthritis - 7, 5 mg of material. The dose may be increased depending on the form and severity of the disease, as well as portability substance methotrexate, but should not be greater than 25 mg per week. From the beginning of drug treatment response is observed 1-2 months after the desired results and reduce the dose can be adjusted to the most effective low dose.

For patients suffering from psoriasis and psoriatic arthritis, the dose is 7. 5 mg, and then gradually increased, reaching 25 mg / week; patients with renal insufficiency and elderly patients should be prescribed cautiously Metodzhekt and depending on the growth of creatinine in the body; a minor under 16 years with juvenile chronic arthritis in the form of polyarteritis should enter from 10 to 20 mg / week intramuscularly.

Overdose

Basically toxins affect metotriksata hematopoietic system . For treatment used sodium or calcium folinate introduced into an organism by intravenous or intramuscular injection, their dosage must be at least metotriksata dose. If there is a large overdose, it is necessary to increase the amount of alkali in the urine and to hold hydration the whole body in order to prevent precipitation of methotrexate in the renal tubules.

Cooperation

Upon receipt of alcohol and drugs that are toxic to the liver and hematopoietic system, increasing the risk of structural and functional disorders of the blood and liver.

Application antibiotic agents   in some cases reduce the excretion process of methotrexate, which leads to an increase in its amount in plasma threatening appearance haematological toxicity . Increase time Withdrawal may occur in the application omeprazole . pantoprazole   as inhibitors of the proton pump.

In the appointment of drugs that can cause in the body reduce the amount of folate, it should also be borne in mind that these substances, such as sulfonamides Increase deficits folic acid   in the body and increase the toxic effects of methotrexate.

Beneficial effect folatosoderzhaschih receiving drugs that reduce the amount of toxins MTX, affecting the bone marrow (multivitamin and others.).

Terms of sale

The drug is sold by prescription.

Storage conditions

This drug belongs to drugs Schedule B . It should be stored in a dry, dark place away from children. The storage temperature of 25 ° C. Freeze is impossible.

Shelf life

2 years.

Reviews Metodzhekte

The most common reviews of Metodzhekte forums on the Internet:

• Metodzhekt, as well as some other medications, which include Methotrexate They are among the most effective agents for diseases such as seronegative arthritis , rheumatoid arthritis, coxarthrosis , Psoriatic arthritis, etc .;
• the use and dosage of the drug should be very strictly controlled;
• the effect of the action of the drug is observed from more than 6 months since the start of the application;
• mandatory daily intake of folic acid tablets to reduce the hepatotoxicity of the drug;
• Many patients take Metodzhekt for 5 years or more, maintaining during this period the required dose of medication in the body.

Reviews for psoriasis:   notes effectively enough substance methotrexate with appropriate treatment.

Price Metodzhekta where to buy

Currently, due to the development of medicine and expansion of trade to buy drugs is not problematic, and the price Metodzhekta average varies from 770 rubles to 1,500 rubles per pack. The price Metodzhekt 15 mg in Moscow on average 1160 rubles, and the packaging of the preparation of 20 mg will cost an average of about 1,400 Russian rubles. It is also possible to buy Metodzhekt 15 mg in Moscow, using the Internet.

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