Description overdue on 04/30/2014
- Latin name: NovaRing
- ATC code: G02BB01
- Active substance: Ethinyl estradiol (Ethinylestradiol) + Etonogestrel (Etonogestrel)
- Manufacturer: Organon, the Netherlands
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use NuvaRing ring (method and dosage)
- Video: How to insert the ring
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 ring contains ethinyl estradiol 2 and 7 mg etonogestrel 11, 7 mg; as auxiliary substances: ethylene-vinyl acetate copolymer, magnesium stearate.
Product form
The vaginal ring is a colorless, transparent, smooth, at the junction - transparent area. The waterproof bag made of aluminum foil.
Pharmacological action
Hormonal contraceptive drug.
Etonogestrel - this progestogen It is binding in target organs with progesterone receptors.
Ethinylestradiol - estrogen . The effect of the drug is provided by a combination of various mechanisms, the most important of which is to suppress ovulation.
Use of the drug controls menstrual cycle Reducing pain during menstrualnopodobnoe bleeding and their intensity. This reduces the chance of developing iron deficiency anemia .
Use of the drug reduces the risk Ovarian Cancer and endometrial development ovarian cysts . ectopic pregnancy , Inflammation of the female reproductive system and benign breast pathology.
Pharmacodynamics and pharmacokinetics
Etonogestrel absorbed through the vaginal mucosa and the maximum concentration is reached after about 7 days. The bioavailability of approximately 100%, which is higher than after oral administration of etonogestrel. The substance is metabolized in the liver and excreted in the urine and bile. The half-life of metabolites - 6 days.
Ethinylestradiol also penetrates through the vaginal mucosa into the blood. The maximum concentration is reached after 3 days. The bioavailability is approximately 56% and is comparable with oral administration. It is metabolized in the urine and bile, half-life is about 36 hours.
Indications
Contraception.
Contraindications
- arterial and venous thrombosis . thromboembolism and predisposition thereto;
- heart disease complications of thrombosis;
- migraine ;
- diabetes with vascular changes;
- pancreatitis ;
- severe liver disease;
- malignant and benign tumors of the liver;
- hormone-dependent cancers (breast and reproductive system);
- vaginal bleeding of unknown origin;
- pregnancy ;
- Hypersensitivity to any of the drug substance (active or auxiliary).
If you experience any of these states to stop taking the drug immediately.
Assign with caution in such cases:
- the presence of a family history of venous or arterial thrombosis ;
- major surgical intervention and interference in the lower limbs, prolonged immobilization;
- obesity with a body mass index of more than 30;
- thrombophlebitis ;
- hypertension;
- smoking (especially women over 35 years old);
- violation of lipid metabolism;
- heart disease ;
- auricular flutter ;
- diabetes;
- liver dysfunction;
- cholelithiasis ;
- hemolytic uremic syndrome ;
- chorea ;
- otosclerosis hearing loss;
- systemic lupus erythematosus ;
- angioedema ;
- ulcerative colitis and Crohn's disease ;
- sickle cell anemia ;
- porphyria ;
- chloasma ;
- case of difficulty, use a vaginal ring: severe chronic constipation Hernia of the bladder and rectum, prolapse of the cervix.
During exacerbation of diseases and deterioration, or if new-onset condition of the above a further question of taking the drug should be addressed with your doctor.
Side effects
In the application may experience the following side effects of NuvaRing, occurring at different rates.
- Infections: vaginal infections and urinary tract, cervicitis .
- Immune System: hypersensitivity.
- Metabolism: increased appetite and weight gain.
- Psychiatric disorders: decreased libido, mood changes, depression .
- Nervous System: headache, dizziness . migraine .
- Bodies of: blurred vision.
- Cardiovascular system: increased blood pressure, thromboembolism , A feeling of "hot flashes."
- Digestive system: nausea, bloating, abdominal pain, diarrhea, constipation, vomiting.
- Skin: acne . itching . rash .
- Musculoskeletal system: pain in the limbs and the back, muscle spasms.
- Urinary system: dysuria , Frequent urination.
- On the part of the reproductive system and breast side effects may occur rings: engorgement and breast pain , Genital itching, dysmenorrhea , Vaginal discharge, amenorrhea Spotting during intercourse, heavy menstruation, uterine bleeding, premenstrual syndrome, burning sensation in the vagina, soreness and discomfort in the vagina.
- The general condition of the body: fatigue, edema.
May also marked discomfort and unpleasant sensations in the vagina.
Instructions for use NuvaRing ring (method and dosage)
Ring administered 1 to 4 times a week into the vagina, where it is 21 days, and then removed. The new ring is inserted after a break of 7 days.
In the 2-3 th day after the removal of the ring starts bleeding, which is associated with the cessation of the drug.
If in the previous menstrual cycle is not used hormonal contraceptives , Contraceptive ring NuvaRing is administered on the first day of menstruation. Installation of up to 5 day cycle, but in this case the first week of the drug is recommended to use a condom.
When changing from a combined oral contraceptive ring is introduced into the last day of the interval between taking hormonal contraceptives. With proper and regular use of combined hormonal contraceptives and confidence in the absence of pregnancy, insert the vaginal ring can be on any day of the cycle.
In the transition from minipill Ring can be used to start any day (the day of removal of the IUD or the day of the next injection). In such cases, the use within 1 week of barrier contraception.
Instructions on the use of NuvaRing allows the ring immediately after the abortion Conducted in the I trimester of pregnancy.
After the II trimester abortion or childbirth are allowed to use to start in the 4th week after abortion or childbirth.
The contraceptive effect may be disturbed when non-compliance, and rules of application.
If during the break to use the ring had sex, pregnancy should be excluded.
When you break the ring hormone secretion does not change. When the ring is usually precipitates from the vagina. It must be replaced by a new one.
How to use NuvaRing
The ring can be independently inserted into the vagina. To introduce you must choose a comfortable position - standing, lifting one leg, squatting, or lying down. When the ring to be compressed and inserted into the vagina.
To remove a ring, it is compressed by the index and middle fingers and removed from the vagina.
Video: How to insert the ring
Overdose
Serious overdose were observed.
There may be slight vaginal bleeding in girls, nausea or vomiting. For the treatment of conduct symptomatically .
Cooperation
Maybe there is an interaction, which manifests itself in the occurrence of acyclic bleeding, with the following medications: barbiturates . carbamazepine . phenytoin . rifampicin . oxcarbazepine . topiramate . felbamate , St. John's wort preparations. During treatment with these drugs, and for 1 month following discontinuation of therapy they need to use a condom.
When antibiotic treatment Ampicillin and tetracyclines You need to use condoms during treatment and for 1 week after discontinuation of the antibiotic, since it can decrease the effectiveness of contraceptives, which contain ethinylestradiol .
The use of suppositories with antifungal drugs increases the risk of damage to the lightly and break the ring.
Hormonal contraceptives may cause changes in the metabolism of other drugs and their concentration in the plasma or peripheral tissues can be increased ( cyclosporine ) Or decrease ( lamotrigine ).
Terms of sale
Prescription.
Storage conditions
Keep out of reach of children and temperatures not lower than 2 ° C and above 8 ° C.
Shelf life
3 years.
Cautions
Hormonal contraceptives may be associated with the development of Venous and arterial thrombosis .
Likely symptoms of thrombosis are:
- pain and swelling in one leg;
- the sudden intense pain in the chest;
- breathlessness or cough paroxysmal character;
- dizziness , Intense headaches;
- sudden loss of vision or double vision;
- speech disorders;
- sudden weakness or numbness of one side of the body or some part of the body;
- traffic violation.
If there are signs of thrombosis hormonal contraceptives to stop immediately and seek medical advice.
The reason for the termination of hormonal contraceptives should be the increase in the severity and frequency of migraine attacks.
Women with hypertriglyceridemia increased risk of pancreatitis.
When predisposition to chloasma is necessary to avoid exposure to ultraviolet radiation of the sun during the application of the ring.
Use of the drug can cause bleeding in the acyclic form of spotting or bleeding occurs suddenly.
Analogs
Septefril
Benateks
Pharmatex
There are analogues of pharmacological group, which includes combined oral contraceptives : Janine . logest . Midian . Novinet . Yarina .
Babies
Safety of drug NuvaRing adolescents up to 18 years has not been studied.
During pregnancy and lactation
The drug NuvaRing is intended to prevent pregnancy.
Use in pregnancy is contraindicated. At its onset - ring removed.
Pregnancy NuvaRing after the cancellation occurs when restoring the natural cycles and normal ovulation.
Use of the drug during breast-feeding is contraindicated.
Reviews of ring NuvaRing
Many women are turning to medical forum with questions about the application of ring NuvaRing. Doctors about NuvaRing mostly as a reliable and efficient means with a minimum of side effects. None of the reviews there was no mention of the occurrence of unwanted pregnancy while taking the drug. Hormonal ring gynecologists is widely used in endometriosis as a deterrent to the development of the disease. Some women report side effects such as discomfort in the vagina, weight gain and headaches.
Price NuvaRing where to buy
Price hormonal ring NuvaRing is about 1,000 rubles. 1 pc. Buy in Moscow pack of 3 pcs. it is possible for 2800 rub. In Ukraine, the average cost of a ring - 220 UAH.
The average price in drugstores in Minsk is 182,200 Belarusian rubles. rub.
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