Description overdue on 11/11/2014
- Latin name: Artrosilene
- ATC code: M02AA10
- Active substance: Ketoprofen (Ketoprofen)
- Manufacturer: Dompe Farmaceutici (Italy)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Artrozilena (method and dosage)
- Overdose
- Cooperation
- Cautions
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
- Part capsules It contains an active ingredient: Ketoprofen Presented in the form of a lysine salt. Additional components: diethyl phthalate, carbopol, povidone, magnesium stearate, polymers of acrylic and methacrylic acid, talc, titanium dioxide, gelatin, indigotine and quinoline yellow.
- Injectable Solution also contains the active ingredient: Ketoprofen - Lysine salt. Auxiliary ingredients: citric acid, sodium hydroxide, sterile water.
- Suppositories Artrozilen It includes in its membership the active substance: Ketoprofen In the form of a lysine salt. Auxiliary components: semi-synthetic glycerides.
- Preparation of gel It includes active substances: ketoprofen - Lysine salt. Additional ingredients: polysorbate, carbopol, TEA, ethanol, neroli and lavender flavor, methylparaben and water are prepared.
- Aerosol It contains the active substance: Ketoprofen - Lysine salt. Accessories: neroli and lavender, polysorbate 80, PPG, benzyl alcohol, PVP, water prepared.
Product form
Artrozilen produced in several pharmaceutical forms, namely in the form:
- Gel for external use 30-50g;
- Capsules for oral administration of 10 pieces in the package;
- injectable solution in ampules of 2 ml in 6 pieces per pack;
- rectal suppositories of 10 pieces in the package;
- outer aerosol 25 ml.
Pharmacological action
For all forms Artrozilena characteristic analgesic, antipyretic and anti-inflammatory effect.
Pharmacodynamics and pharmacokinetics
Manifestations of anti-inflammatory, analgesic and antipyretic effect is provided to inhibit the ability of ketoprofen COX-1 and -2, to inhibit the synthesis of PG. Furthermore, characteristic for the preparation antibradikininovaya activity, stabilization of lysosomal membranes and inhibition of release from the enzymes That contribute to tissue destruction in chronic inflammation. Reduced release of cytokines, slows down the activity of neutrophils.
Application Artrozilena to reduce morning stiffness, joint swelling, increase range of motion.
Included in the preparation of ketoprofen lysine salt, a neutral molecule with a fast dissolving in pH. Therefore Artrozilen practically no irritating effect on the gastrointestinal tract.
Outdoor use spray or gel Provides local anti-inflammatory, anti-exudative and analgesic effect. This shows a high local therapeutic effect on affected joints, tendons, ligaments, muscles. Treatment with the drug articular syndrome allows ease joint pains as at rest and during movement, reduced morning stiffness and swelling of joints. Established that Artrozilen no damaging effect against articular cartilage.
When administered capsules, the active substance is fully absorbed from the gastrointestinal tract, with higher bioavailability of 80%. The maximum concentration is reached after 4-10ch since the reception, depending on the dosage. Thus the therapeutic effect lasts 4-24 hours. The use of food may decrease the concentration of the substance in the body. Inside the body marked by a complete connection ketoprofen plasma proteins. The substance can penetrate blood-tissue barriers, tissue and synovial fluid, where it occurs and distribution. Metabolism ketoprofen in the liver, with the development of glucuronidation subjected esters and glucuronic acid. Withdrawal metabolites It carried out as part of urine and a small part of a stool.
Action manifests injection after 20-30 minutes and is maintained for 18-20 hours. The active substance is fully absorbed by binding to plasma proteins. The drug penetrates the blood-tissue barriers in the body fluids and tissues, uniformly distributed in the body. Metabolism occurs with the participation of the liver enzymes that preferentially excreted by the kidneys within 24 hours.
When using the drug in rectal suppositories manifests its action in 45-60 minutes. The maximum concentration of a substance is directly dependent on the dose received. In the body, ketoprofen fully absorbed by binding to plasma proteins. It noted the penetration of substances through the blood-tissue barriers that are distributed in the tissues and important organs. Metabolism occurs in the liver, with production of ethers and glucuronic acid. Excretion of metabolites occurs in urine composition.
The use of external funds gel and aerosol noted the slow absorption. The effect of the substance is shown for a short time and maintained for 5-8 hours. The bioavailability is approximately 5%.
Indications
The main indications for the use of capsules and suppositories are:
- inflammatory, post-surgical or post-traumatic weak and moderate pain;
- rheumatoid and gouty arthritis ;
- osteoarthritis ;
- spondylitis;
- inflammation of the periarticular tissues.
The injections are prescribed for short-term treatment of acute pain syndromes accompanying:
- diseases of the musculoskeletal system of different origin;
- post-traumatic and post-operative pain associated with inflammation.
Indications for use of the gel and aerosol are:
- diseases of the musculoskeletal system, for example - rheumatoid and psoriatic arthritis, osteoarthritis peripheral joints and spine, ankylosing spondylitis, rheumatic damage soft tissue;
- traumatic soft tissue
Non-rheumatic rheumatic and muscular pain.
Contraindications
- high sensitivity to the drug;
- Aspirin asthma;
- lactation, pregnancy;
- aggravation of gastric ulcer and 12 tiperstnoj ulcer, peptic ulcer;
- diverticulitis;
- acute form of ulcerative colitis, Crohn's disease;
- chronic renal failure ;
- children's age;
- hemophilia and other disorders associated with blood clotting, and so forth.
Aerosol and ointment and is not recommended if:
- weeping dermatosis ah;
- eczema;
- violation of the integrity of the skin.
Use caution is required when treating patients:
- asthma;
- congestive heart failure;
- anemia;
- alcoholism;
- liver failure;
- diabetes and so on.
Side effects
Application Artrozilena can lead to disturbances in the activity of the gastrointestinal tract, liver, nervous system, sensory organs and blood, genitourinary, cardiovascular and respiratory systems.
In addition, it is possible to develop various disorders of the skin and allergic reactions.
When using external preparations - gel and spray, it is possible occurrence of photosensitivity.
In any case, need to consult a specialist.
Instructions for use Artrozilena (method and dosage)
The drug is available in several pharmaceutical forms intended for oral, rectal, parenteral and externally.
Tablets for oral administered daily for one thing at the same time or after a meal. The therapeutic course may last 3-4 months.
Solution w / o or w / administered according to the use ampoule per day. Typically, this form of the drug is used for short-term treatment is not more than 3 days in the hospital. When it is necessary to continue the treatment, it is allowed to use capsules or suppositories.
Rectal suppositories are used every day for 1 piece 2-3. The maximum daily dose should not exceed 480 mg. Elderly patients prescribed daily dose to 2 suppositories.
The outer form of an aerosol and gel Artrozilen instructions for use recommends to put in a small amount every day for 2-3 times. This single aerosol dose of 1-2g. The duration of therapy by a doctor, but it should not be longer than 10 days.
Overdose
Cases of drug overdose Artrozilen not described.
Cooperation
Concomitant use with inducers of microsomal oxidation in the liver - phenytoin, barbiturates, flumetsinolom, rifampicin, phenylbutazone, tricyclic antidepressants increases the production of hydroxylated active metabolites.
It is established that reduces the effectiveness of some Artrozilen urikozuricheskih funds It enhances efficiency a ntikoagulyantov, fibrinolytic agents, antiplatelet agents . side effects mineralocorticoid, estrogen . and antihypertensive and diuretics .
Sharing with NSAIDs, corticosteroids, corticotropin, ethanol can cause the development of ulcers and bleeding gastrointestinal, increase the probability of abnormalities of kidney function.
Together with the application oral anticoagulants, thrombolytics, heparin, cefoperazone . Tsefamandol antiplatelet and tsefotetanom It increases the risk of bleeding.
Furthermore, active drug enhances hypoglycemic effect insulin and hypoglycemic agents, so while the appointment is required recalculation of the dose. Combination with valproate It leads to violations of aggregation Platelet , from verapamil, nifedipine, lithium, methotrexate increases their concentration in the composition of the plasma. Combined with reception santatsidom and kolestiraminom It may reduce the absorption of Artrozilena.
Cautions
In the treatment of capsules, injections and suppositories requires monitoring of peripheral blood, as well as the state of the liver and kidneys.
When you need to determine the 17-ketosteroids, then cancel before the study medication for 48 hours.
The use of ketoprofen often masks the symptoms of an infectious disease.
Impaired renal function and liver require lowering the dosage and careful monitoring of the patients.
Patients suffering asthma , It may be an attack of asthma.
When planning a pregnancy, it is recommended to refrain from using drugs as possible to reduce the likelihood of implantation of the egg.
Aerosol and Gel Artrozilen should be applied to the skin without any damage. It is important that the drug does not get into the eyes and mucous membranes. Avoid manifestations of hypersensitivity or photosensitivity possible if protect the skin from sunlight during the treatment.
Terms of sale
A preparation in the form of capsules and injectable solution prescription. Ointment and Spray Artrozilen are non-prescription drugs.
Storage conditions
For storage of the drug is designed dark place, protected from children at a temperature of 25 ° C.
Shelf life
3 years.
Analogs Atrozilena
Diklovit
Naklofen
Olfen
Fast Fanigan
Feloran
Fastum gel
Nise
Diclofenac
Dolgit
Dolar
Flamidez
Ketonal
Ketorol
Indomethacin
In modern pharmacology developed a number of tools such action. Analogs of this drug: Ketoprofen, Ketonal, Oruvel, Profenid, Knavon, Fastum, Febrofid, Aktron, flexo, Ketoprofen-ratiopharm, Ultrafastin, Artrum, Flamaks, Ketolist retard Alreumant, Asozal, Ostofen, Sinprofen and so on.
Alcohol and Artrozilen
Simultaneous application of the drug and alcohol enhances its effect and increases the risk of bleeding LCD.
Reviews Artrozilene
As the reviews Artrozilen gel, its effectiveness is shown not in all cases. Posts on the forums show that this drug is often prescribed for the treatment of gout . However, the simultaneous use of the gel capsules and bring relief only when the therapy is conducted in the early stages of the disease.
However, this drug is very good for the treatment of pain of traumatic nature, such as bruises . There are reports of how using Artrozilena patients eliminate inflammation of the joints. Of course, if the pain and other undesirable symptoms persist for a long time need to see a doctor rather than trying to choose their own treatment.
Price Artrozilena where to buy
Cost suppositories for rectal use 160 mg of the 10 pieces is 220-370 rubles.
Injectable Solution To put injections in 2 ml ampoules, 6 pieces in a package worth 160-190 rubles.
Tablets or capsules 320 mg of 10 pieces in a pack can be bought for 270-320 rubles.
Cost gel Artrozilen 15% varies between 270-320 rubles.
Cost spray It is 280-300 rubles.
No comments:
Post a Comment