Description overdue on 07/18/2014
- Latin name: Gynoflor A
- ATC code: G02CX
- Active substance: Lyophilizate acidophilus lactobacillus (Lactobacillus acidophilus) and estriol (Estriolum)
- Manufacturer: Invar (Russia); Haupt Pharma Amareg (Germany); Medinova Ltd. (Switzerland)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Gynoflor E, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 tablet E Gynoflor for vaginal use as active ingredients comprising:
- lyophilisate lactobacillus acidophilus groups ( Lactobacillus acidophilus
- theelol - 0, 03 mg.
Auxiliaries existing core are:
- lactose monohydrate - 625, 6 mg;
- microcrystalline cellulose (MCC) - 183, 7 mg;
- carboxymethyl - 30 mg;
- magnesium stearate - 6, 67 mg;
- Sodium dihydrogenphosphate - 4 mg.
Product form
biconvex vaginal tablet (also known as release forms - candles Gynoflor E ) Oval 50 mg each, which are fixed in aluminum foil blisters of PVC or 6 pieces. Tablets white or light beige color with a splash of (possible intermediate shades of these colors). The carton is put 1 or 2 contour cell plate.
Pharmacological action
Components of the pharmaceutical preparation Gynoflor E are part of the physiological mechanism for the maintenance of normal vaginal biocenosis . This is the main purpose of using the drug in the conservative therapy.
Lactobacillus acidophilus - The dominant faction of the microorganisms that live in the vagina of healthy women. They have an antagonistic activity to the malicious and opportunistic pathogenic microflora. The mechanism of the protective function lies in the allocation of micro-organisms bacteriocins and hydrogen peroxide Thus, kept clean genitals.
Also, the beneficial bacteria are able to balance the physiological parameters of the medium for normal metabolic processes. Lactobacilli fermented vaginal epithelium glycogen to lactic acid and, thus, maintain an acidic pH of 3, 8-4, 5.
- Artificially synthesized compound, which by its chemical structure is identical to the female sex hormones estrogens short-acting). Composite component of the drug has a pharmacological specificity of action - has an effect only on the mucous membrane of the vagina. It stimulates growth and proliferation of the epithelial covering of the inner female genitals, thereby improving the operation of a natural barrier against infections of all kinds. Also, this cell structure contains glycogen
A special role in pharmaceutical tablets Gynoflor play and auxiliaries. For example, lactose , Part of the drug can be fermented to lactic acid by lactobacilli in the first period of conservative therapy, when proliferating action estriol It has not yet developed into full force.
Vaginal Tablets are used not only at disproportionate violation of the microflora of the internal environment female genitals, but also in hormonal imbalance . Actively used in times Gynoflor Menopause and menopause Which are usually marked by symptoms such as:
- itch ;
- burning ;
- soreness during intercourse and urination.
By promoting the normalization of the epithelium of the urogenital system, these symptoms are stopped by the action estriol for the coating layers. According to this mechanism Gynoflor pharmacological effects, it may be used as preventive prophylaxis dystrophic .
Pharmacodynamics and pharmacokinetics
After the introduction of the drug into the vagina the constituent components are released gradually, as their decomposition under the influence of internal factors of the environment. Freeze-dried bacteria have only local effect and are not absorbed into the systemic circulation. Their influence is noted after several hours.
Theelol Maximum plasma concentrations observed after 3 hours after administration of the pharmaceutical preparation. Estriol not cumulate (after the re-introduction of plasma concentration corresponds to the amount of unbound estriol ) And does not affect the production of endogenous estrogen series ( Estrogen and Estradiol ), As is the final link of the metabolic chain. Gynoflor output composite components in the urine within 8 hours.
Indications
- resumption physiologically normal microflora After topical or systemic treatment of antibiotic drugs;
- Light to moderate bacterial vaginosis or candidiasis (pharmaceutical preparation can be used both as conservative treatment and prevention of disease prevention);
- no specific vulvovaginitis ;
- urogenital infectious diseases (usually sexually transmitted);
- atrophic vaginitis hormone replacement therapy ;
- Bacterial isolation of unknown origin ( Fluor vaginalis );
- in complex medical treatment against infectious nature to maintain normal microflora women.
Contraindications
- Hypersensitivity, inherited or acquired intolerance to the constituent components of the pharmaceutical formulation;
- malignant neoplasms Dependent on estrogen (in particular in the localization process in the mammary gland, uterus, ovary or vagina);
- diagnosed or suspected endometriosis ;
- hemorrhagic selection from the vagina of unknown origin;
- hyperplasia endometrial ;
- use in girls before puberty (before the onset of sexual activity).
Side effects
Generally, vaginal tablets transferred to the female body good, but in some clinical situations may experience the following adverse effects of treatment:
- burning sensation , Foreign body, feeling the heat or another kind of discomfort after administration;
- allergic reactions - Redness and swelling of the mucous membrane of the vagina or the external genitalia;
- Arterial hyperemia and itching of the vulva .
In case of accidental oral pharmaceutical preparation negative effects will not be observed.
Instructions on candles Gynoflor E It requires a deep vaginal tablets administered into the vagina. It is recommended that the manipulation of the evening, before going to bed, as the night the body's absorption capacity is much higher. For ease of use the tablets are administered in the supine position, with a slight bend of the knees - so the inlet of female genital mutilation as openly as possible, and therefore the use of the drug causes little discomfort.
The course of conservative treatment varies based on the indications for drug treatment:
- To and proliferative effects on epithelia using 1-2 tablets daily for 6-12 days. For more precise recommendations should be obtained from your doctor, as they depend on a variety of indicators of an organism and the type of pathology.
- With the treatment of atrophic lesions during Menopause and menopause dosage of medicament reduced to 1 tablet every day for 6-12 days. Further supportive therapy is even less of a pharmaceutical preparation - Use 1 tablet 1-2 times a week. The duration of the first phase of the therapeutic set according to the individual physician level of hormones over a period of conservative rehabilitation.
At the time of treatment the pharmaceutical Gynoflor recommended abstain from sex or regularly use barrier methods of contraception So that the therapeutic effect of the drug was reduced intake exogenous pathogenic or opportunistic microorganisms.
Overdose
No cases of overdose of pharmaceuticals in clinical practice is not fixed.
Cooperation
Lacto acidophilus Which are one of the major constituents of the drug is extremely sensitive to a wide range of antibiotics Because of local antimicrobial therapy or systemic nature greatly reduces the efficacy of the pharmaceutical.
Terms of sale
Storage conditions
Gynoflor pharmaceutical preparation should be stored in a dry place away from children and to direct sunlight at a temperature of 2-8 degrees Celsius (in any case not be frozen drug, because in this way to lose all the pharmacological properties of the components).
Short Gynoflor storage (no more than two weeks) in the temperature range of 15 to 25 degrees centigrade do not lead to a reduction of its therapeutic effectiveness.
Shelf life
3 years.
Cautions
Components of the drug may Gynoflor E completely soluble under the influence of internal factors of the vagina. In this case, vaginal tablet residues can be found on the bottom or bed linen, but the effectiveness of the drug is not affected (residues are auxiliary substances which fulfill its pharmacological job).
In cases where the notes vaginal dryness Should wet the tablet before it is introduced a small amount of plain water, so as to contribute to its more rapid dissolution. During conservative treatment is recommended for women to use spacers if spark further moistened.
The drug Gynoflor E does not affect the possibility of prolonged concentration, fine motor skills, coordination and the ability to drive vehicles or other potentially life-threatening mechanisms.
Analogs Gynoflor E
Klimaktoplan
Mamoklam
Tazalok
Ovarium Compositum
Klimadinon
Klimadinon Uno
Klimalanin
Cyclodynon
Normal microflora of the internal environment of the vagina - a very important parameter of the physiological functioning of the female reproductive organs, because analogs Gynoflor constitute a large group of pharmaceutical options, which includes as candles and tablets for intravaginal use.
As a rule, individual contraindications therapeutic effect of the drug is replaced by the following medications: Vagisan . Ekofemin . Laktogin or Laktovag .
Synonyms
Vagilak . Vaginorm C
With alcohol
During pregnancy and lactation
Components of the drug have not Gynoflor embriotoksicski . terato- or fetal development, because the drug is allowed to be used during pregnancy and breast-feeding (lactation). However, a conservative therapy first trimester It recommended only under the constant supervision of qualified medical personnel and regular diagnostic assays.
The vast majority of women who used the drug for conservative therapy, recommends the use of vaginal tablets at the slightest deviations of physiological parameters . Their opinion is based on the fact that the constituent components can help to protect and improve nutrition of the vaginal mucosa.
Oddly enough, but the source of the positive reviews on candles Gynoflor E is not a Pharmaceutical Forum, and themed online community for women.
Like the vast majority of women are applied vaginal suppositories, the medical staff is also happy to data drug. In clinical practice, it is not known cases of overdose, and because, even in violation of the therapeutic regimens or high doses of a pharmaceutical preparation adverse effects or enhance the adverse effects are not observed. Positively characterizes Gynoflor and duration of readjustment, because it is a negligible amount of time to restore the normal functioning so important for women officers.
Price Gynoflor Oh, where to buy
Price Gynoflor in the Russian Federation is prohibitive, both so important for the normal functioning of the female reproductive organs of the drug. The cost of the tablets varies within 600 rubles per 6 tablets and 900-1000 rubles per 12 tablets.
Ukraine in this respect, a little more happy, because the price of candles Gynoflor E on its territory is only 90-120 hryvnia.
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