Marvelon

Description overdue on 01/08/2014

• Latin name: Marvelon
• ATC code: G03AA09
• Active substance: Desogestrel (Desogoestrelum) Ethinyl estradiol (Aethinyloestradiolum)
• Manufacturer: ORGANON N.V., Netherlands

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Marvelon: method of use and dosage of the drug
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

In addition to members of the active ingredients Marvelon, each tablet contains adjuvants:

• silicon oxide, colloidal anhydrous ;
• potato starch ;
• lactose monohydrate ;
• stearic acid ;
• povidone ;
• alpha-tocopherol .

Product form

Marvelon available as packaged in blisters to 21 pieces of tablets for oral use. One package may contain one drug, 3 or 6 blisters simultaneously.

The tablets are round, biconvex shape, painted white. On one side there is the marking "TR 5" on the other embossed inscription "ORGANON".

Pharmacological action

Marvelon belong to the pharmacological group hormonal contraceptive drugs   for oral administration.

Through its member desogestrel , Which is used as progestin And ethinyl estradiol , Which is used as Estrogen He has a strong estrogen-progestogen contraceptive effect and prevents unwanted pregnancies.

Besides Marvelon also provokes a number of other positive effects:

• makes menses more regular and less painful;
• reduces the severity of menstrual bleeding ;
• reduces the risk of anemia Associated with iron deficiency in the body;
• reduces the risk of   fibrocystic disease ;
• prevents the appearance of cysts;
• prevents the development of inflammatory diseases in the pelvic area;
• prevents the development of ectopic pregnancy ;
• reduces the likelihood of cancer .

Pharmacodynamics and pharmacokinetics

Contraceptive effect of the drug is determined by its ability to inhibit the active ingredients Ovulation   and to increase the production of cervical (cervical) mucus.

Progestogens   substance desogestrel   promotes inhibition of production of gonadotropic cells of the anterior pituitary luteinizing hormone and follicle-stimulating hormone , Which in turn prevents the normal maturation follicle   and thus blocks the offensive Ovulation .

Besides that, desogestrel :

• It affects the composition of mucus fills the cervical canal and provokes its thickening. As a result - cervical mucus becomes impassable obstacle for sperm .
• It helps reduce Estradiol   to values ​​that are characteristic of the early follicular phase.
• Do not provoke any major disturbances in metabolism carbohydrates   and lipids . In contrast, after treatment desogestrel   plasma concentration is increased Lipoprotein   high density lipoproteins (HDL), and the level of Lipoprotein   low density (LDL) cholesterol remains unchanged.
• It does not have any effect on the blood coagulation system ( hemostasis ).
• It reduces the number of lost blood parameters in women who have previously observed menorrhagia   or, in other words, heavy menstruation Accompanied by higher than normal physiological blood loss.
• It helps improve skin condition in the presence of her acne .
• Promotes normalization menstrual cycle .
• It prevents the development of certain gynecological diseases, including including the nature of the tumor disease.

Ethinylestradiol   It is a synthetically produced hormone agent estrogen series, which in their pharmacological activity similar to the most basic and active for human female sex hormone estradiol .

While taking ethinyl estradiol   in the body:

• there is an increase endometrial tissue   through greater division of its cells;
• stimulated the development of the uterus;
• It stimulated the development of secondary sexual characteristics in women (if they were underdeveloped);
• soften and eliminate the consequences of insufficient gonadal function ;
• reduced performance levels cholesterol   in blood;
• stimulates an increase in blood levels beta-lipoprotein ;
• increases the level of sensitivity to Insulin ;
• normalizes the processes for glucose utilization.

High doses ethinyl estradiol   lead to a reduction, and small - on the contrary - to increase the activity of production of f ollikulostimuliruyuschego hormone (FSH), pituitary .

Desogestrel   when taken orally it is capable of quickly and as fully absorbed from the stomach and intestines. At the same substance in biotransformiroetsa etonogestrel .

Bioavailability desogestrel   It varies from 62 to 81%. Daily taking it provokes an increased concentration of etonogestrel   in serum is approximately two to three times.

Desogestrel   and formed during its biotransformation metabolites excreted by the kidneys in urine.

Etonogestrel   capable of binding to SHBG (globulin responsible for the binding of hormones) by 40-70%, as well as albumin . The free form is from 2 to 4% of the material.

Ethinylestradiol   provokes an increase in the concentration responsible for the binding of hormones globulin   three times, thereby enhancing the SHBG fraction is associated with etonogestrel   and simultaneously reducing the fraction associated with   albumin .

Ethinylestradiol   totally biotransformed in the body, but the process of absorption when administered orally from stomach and intestinal tract is rapid and almost completely. Indicator substances bioavailability is about 60%.

The main mechanism of metabolism ethinyl estradiol   It is   aromatic hydroxylation . Formed during the biotransformation metabolites excreted by the kidneys in urine, as well as together with bile, a ratio of 4: 6.

Indications

Birth control pills Marvelon shown to prevent the onset of unwanted pregnancy .

Contraindications

The main contraindications to the drug - is:

• Available patient now or in award history thrombosis of the large blood vessels   (in particular, veins and arteries).
• Those present at the moment or with a history of clinical manifestations, which is accompanied by thrombosis (eg, angina   or Coronary artery disease ).
• The presence of the patient Diabetes Which is accompanied by vascular lesions.
• Have the patient clearly manifested or present plural risk factors development of venous or arterial thrombosis .
• Those present at the moment or with a history of severe liver disease   (in the cases where the functional characteristics are abnormal liver).
• Those present at the moment or with a history of the disease of tumor nature (the matter concerns both benign and malignancies ).
• The presence of the hormone-dependent patient malignancy in the breast or in the organs of the reproductive system (also for suspected it).
• Vaginal bleeding   uncertain nature of origin.
• Gestation   (or suspected).
• Lactation.
• Migraine Which is accompanied by focal neurological deficit.
• Increased concentration triglycerides   plasma ( triglitseridermiya ).
• Hypersensitivity to any component of the drug.

Side effects

In some cases, while taking Marvelon, some women may experience side effects that are expressed in the form of violations of the functions of individual organs and systems.

So, from the reproductive system are not excluded:

• the probability of occurrence of genital tract intermenstrual bleeding th;
• violation of cervical secretion;
• and coarsening swelling of the breast ;
• amenorrhea .

The most likely side effects that arise from the gastrointestinal tract - nausea and vomiting .

Central nervous system can respond to the drug by symptoms such as dizziness , Mood lability, headache   or migraine .

In some cases, there may be a delay in the body fluid and fluctuations in body weight. It is also possible:

• appearance chloasma ;
• appearance nodosum (nodosa) erythema ;
• the appearance of rashes on the skin;
• reduction or complete portability tolerability of contact lenses;
• increased risk of acute blockage of a blood vessel by a thrombus.

Instructions on Marvelon: method of use and dosage of the drug

Marvelon for oral administration. Tablets are recommended to take one, at one and the same time of day, with liquid squeezed small amounts of liquid, strictly following the order indicated on the package.

The duration of the course is 21 days. Further continue taking the drug seven days after the end of the first year. This is due to the fact that during these seven days of a woman's menstruation should occur.

Most often, it begins in the second or third day after taking the last tablet, and in some cases may not be completed before the start of the new course of taking the pills Marvelon.

If hormonal contraception have not been applied during the previous menstrual cycle , Taking pills is recommended to start with the first day of a new menstrual cycle.

It is also allowed to start taking the drug in the range between 2 and 5 days of the cycle. However, it is important to remember that the contraceptive effect occurs only after seven days. For this reason, in the first week of receipt of the first menstrual Marvelon pill it is recommended to combine with the use of non-hormonal methods of prevention pregnancy .

In the transition to the other after taking Marvelon hormonal contraceptives , The drug is optimal to start the next day after taking the last pill previously used tools.

In the transition to estrogen-progestin   on contraception progestin   means which include minipill . Implants and contraceptives in the form of injections, reception Marvelona begin:

• on any given day, if previously used for contraception minipill ;
• on the day of removal implant If previously used this method of contraception;
• on the day of the alleged next injection if you have previously applied for contraception injection therapy .

And in each of these cases during the first week of the course taking the pill should be supplemented by additional methods of contraception.

Women who have had abortion   in the first trimester of pregnancy is allowed to begin taking the drug immediately, without the need for additional contraception.

After delivery And after abortion   during the second trimester pregnancy , Courses start on the 21 th or 28 th day. If you start taking Marvelon at a later date, during the first week of the course it is combined with the use of barrier contraceptives.

Moreover, if a woman after delivery   or procedures abortion   before you start taking the tablets have already taken place have sex, you should exclude the possibility of the onset of a new pregnancy .

In accordance with the instructions for use when Marvelona Missed pills reliability of contraception remains unchanged for the next 12 hours. A woman should take the tablet as soon as when she thinks of her subsequent tablets are taken on the usual scheme, and at the usual time.

If the interval between doses tablets than 12 hours kontratseptsionny effect of the drug is reduced.

If the pass occurred during the 1st week course of treatment with Marvelon, the woman should take the tablet as soon as when she remembers about it (even if it involves the simultaneous reception of two tablets).

In the future course of continuing the scheme described above at the usual time, but using the pill supplement barrier contraceptives . In those cases where the previous week the woman had unprotected sex, it is important to take into account the fact that she could get pregnant at this time.

Moreover, the more missed tablets and the closer woman pause in taking the drug at the time of sexual intercourse, the greater the chance of pregnancy is considered.

If you took a pass on the 2-week course of treatment with Marvelon, are encouraged to take the next pill at once, the woman to remember it, then continue on the course of the scheme described above.

If during the week before missed doses taken daily, the need to use additional methods of contraception is not. If gaps in the past week have been or are currently woman misses more than one pill, you should use barrier contraceptives   for 7 days.

If there was a pass for the 3rd week course of treatment with Marvelon, reliability Contraception   It can be reduced due to a break in the subsequent dosing. To avoid this, as well as the need to use an additional barrier contraceptive, it is recommended to resort to an adjustment of the dosage regimen.

An obligatory condition is the lack of gaps in the pill during the previous 7 days. Otherwise, after the resumption of the course of taking the pills should be combined with other methods of contraception.

The woman should take the missed pill as she remembered about it, even if it involves the simultaneous reception of two tablets. The further course continue on the usual scheme.

New drug packaging begins when the previous end, then there is a break between packs is not done. The probability of occurrence vaginal bleeding   before the end of the second package is considered extremely low. However, it is possible that some women may appear slight smearing, and sometimes quite abundant selection even during the course of treatment.

Another option adjustment schemes use Marvelona involves discontinuation of the current package and maintaining a seven-day interval before the next. It should take into account the days that were in the blanks.

If the gap in the employment drug is accompanied by lack of menses This may be indicative of pregnancy . Therefore, before you resume the course to exclude the possibility of it.

If the intake of Marvelon developing a side effect such as vomiting , Absorption of the drug may be incomplete. In such situations, one should resort to the recommendations relating to the crossing receive the regular pill.

If a woman does not want to change the usual regimen, manual recommends that more tablet of the drug (or more tablets) from another pack.

If you want to delay the onset of menstrual bleeding, continue to take Marvelon without making the usual seven-day break between packs. Postpone menstruation   thus it is possible at any time interval before the end in the second tablet container.

In this period can be observed little or abundant bloody vaginal discharge . As usual pattern starting to take the drug after holding seven-day tablet-free interval.

If you want to move the start of the day menstrual cycle   with alleged in the case of following the usual scheme of the drug to another, provided the instruction break between packs to reduce the required number of days.

The shorter the interval, the higher is the risk of a lack of menstrual bleeding during the break, and the risk of heavy vaginal discharge while receiving Marvelona the second pack.

Overdose

AND desogestrel   and ethinylestradiol   They are substances of low toxicity, so the risk of endangering the health of women, the symptoms of an overdose is assessed as very low.

If you accidentally while taking a few pills Marvelon in some cases may occur:

• vomiting ;
• nausea ;
• slight bloody vaginal discharge   (young patients).

Antidote   to the drug does not exist. When a patient shows signs of an overdose symptomatic treatment .

Cooperation

Kontratseptsionny Marvelona effect is suppressed with a combination of the drug with:

• rifampicin ;
• hydantoin derivatives ;
• carbamazepine ;
• grizeovulfinom ;
• isoniazid ;
• topiramate ;
• primidone ;
• oxcarbazepine ;
• felbamate ;
• barbiturates .

In addition to reducing the effectiveness of funds may also experience heavy bleeding from the vagina .

Oppression contraceptive effect contributes to the simultaneous reception of Marvelona antibiotics Belonging to penicillin series . antibiotics   from the group tetracyclines . neomycin . chloramphenicol . charcoal   and its analogues, drugs, providers laxative effect .

In turn, reduces the therapeutic effectiveness of Marvelon:

• coagulants Intended for oral administration;
• preparations anxiolytics ;
• tricyclic antidepressants ;
• caffeine ;
• theophylline ;
• antidiabetic   drugs;
• clofibrate ;
• GCS ( glucocorticosteroids at).

Terms of sale

Holiday preparation is carried out with a prescription.

Storage conditions

Keep Marvelon is recommended in a dry place inaccessible to children, sheltered from sunlight. The optimal temperature - 2-30 ° C.

Shelf life

The drug retains its pharmacological properties over 3 years. The use after the expiry date is prohibited.

Analogs

Analogs of the drug Marvelon:

• Regulon ;
• Three-Mercy ;
• Mersilon ;
• Novinet .

Each of these combination preparations comprising   desogestrel   and ethinyl estradiol   and, by and large, their main difference from each other is the price. For example, assigning Marvelon patient, the doctor may recommend it as an alternative to medication Regulon .

If the question arises, what is better - or Marvelon Regulon

. hormonal imbalance   acne menstrual cycle .

. libido .

pregnancy  

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