Loratadine

Description overdue on 26.11.2011

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Allergy medication. Loratadine blocks H1-histamine receptors over time. Blocks production leukotriene C4   and histamine   from mast cells. The drug is easier for allergies, prevents its development. In addition to the anti-allergic effect, loratadine has protivoekssudativnoe and antipruritic effect. The drug relieves spasm of smooth muscle tissue, prevents the development of edema, reduces the permeability of the capillary walls. Antiallergic action develops in half an hour after receiving the drug in the body, the maximum effect is recorded through 8h, duration - day. Loratadine is not addictive, does not affect the central nervous system. The drug does not pass through blood-brain barrier . It is produced in the form of tablets, syrup and suspensions for oral administration.

Indications:

Loratadine is used for year-round, seasonal allergic rhinitis, hay fever , Conjunctivitis, idiopathic urticaria, itching dermatoses   ( chronic eczema , Contact allergodermia), chronic urticaria, angioedema, allergy to insect bites. The drug is effective in pseudoallergic reactions Caused by histamine release. Loratadine is indicated for the treatment of bronchial asthma (in the complex therapy).

Contraindications:

Loratadine is not indicated during breastfeeding. To use caution in the pathology of the renal system, pregnancy.

Side effect:

Gastrointestinal tract : Anorexia, dry mouth, violation of salivation , Taste perversion, weight gain, dyspepsia, flatulence , Gastritis, stomatitis , Toothache, increased appetite, disorders of the chair. Rarely observed   hepatic necrosis , Hepatitis, jaundice . Nervous system and sense organs : Fatigue, drowsiness, dizziness, impaired concentration, nervousness , Insomnia, anxiety, paresthesia , Tremor of limbs, hyperkinesia, depression , Memory impairment, dysphonia . nictitating spasm , noise in ears, sore eyes , rarely - convulsions . Genito-urinary system : Painful urination, menorrhagias . dysmenorrhea . impotence . the weakening of the libido . vaginitis , Edema. Cardiovascular system : Unstable blood pressure, tachycardia, palpitation, supraventricular tachyarrhythmia. Locomotor apparatus : Arthralgia, back pain, leg cramps, myalgia . Respiratory system : Epistaxis, nasal congestion, pharyngitis , Sinusitis, cough, laryngitis , Hemoptysis, bronchospasm . bronchitis . dyspnea , Upper respiratory tract infection, chest pain. Allergic reactions : Dermatitis, hives, skin rash, redness, itching, anaphylactic shock, angioedema . Other reactions : Asthenia, thirst , Dry skin and hair, fever, malaise, photosensitization , Chills, pain in the breast, alopecia, weight gain, erythema multiforme Increase in the dimensions of the thorax.

Mode of application:

Loratadine taken orally once a day. Adults and children from 12 years: 10 mg. Babies 2-12 l (weight less than 30 kg) - 5 mg. With a weight of over 30 kg dose increased to 10 mg. When liver failure system - 5 mg.

Overdose:

Manifested tachycardia , Drowsiness, headaches. Children may develop extrapyramidal disorders , Palpitations. It is recommended that induction of retching syrup ipecac Reception activated carbon. Hemodialysis is ineffective, there is no antidote.

Special instructions:

Loratadine slows psychomotor reactions, negative impact on attention. In the period of treatment to give up driving vehicles, activities that require high concentration.

Drug Interactions:

Cimetidine, erythromycin .   ketoconazole   and other inhibitors SYR3A4 increase the concentration of loratadine. Phenylbutazone, phenytoin, barbiturates, ethanol, rifampicin . tricyclic antidepressants   and others Inductors of microsomal oxidation   significantly reduce the efficacy of loratadine.