Azithromycin

Description overdue on 14.12.2011

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Antibacterial drugs, azalide . It has bacteriostatic action. The mechanism of action is based on binding to the ribosomal subunit, oppression peptidtranslokazu during the broadcast suppression of the protein in the microbial cell, slowing the growth process, the growth of bacteria. In high concentrations has bactericidal action . Active against intracellular and extracellular pathogens effect on gram-positive, gram-negative flora. Bacteria that are resistant to erythromycin Do not respond to antibiotic therapy with azithromycin. The drug is available in tablet form, capsule form, a lyophilisate, powder, and granules for suspension.

Indications:

Azithromycin prescribed for infection of the upper respiratory tract, ENT diseases: sinusitis, tonsillitis . laryngitis . pharyngitis . otitis media . scarlet fever . The drug is effective in bronchitis , Pneumonias, infections of soft tissue, skin, negonoreyny urethritis . Lyme disease . cervicitis . dermatosis . impetigo , Erysipelas, gonorrheal urethritis , Ulcerative lesions of the gastrointestinal tract (vyzv. Helicobacter pylori).

Contraindications:

Azithromycin is not used in severe renal disease, hepatic systems, allergies to macrolides. With caution is prescribed for adults, pregnant (with a careful reassessment of the possible risks to the fetus and the importance of the therapeutic effect). The drug is not used in pediatrics, breastfeeding.

Side effect:

Digestive system : cholestatic jaundice , Dyspepsia, flatulence, disorders stool, melena, increased liver enzymes, gastritis, decreased appetite, kindidamikoz   the oral mucosa. Cardiovascular system : Chest pain, heart palpitations. Nervous system : Drowsiness, vertigo , Headache, dizziness, neurosis , Anxiety, hyperkinesia Sleep disorders. Genito-urinary system : jade . vaginal candidiasis . For intravenous administration, tenderness, inflammation at the injection site. It is also possible to develop photosensitivity , Fatigue, allergies, conjunctivitis. Overdose manifested by diarrhea, temporary hearing loss, severe nausea, vomiting. Treatment posimptomnoe.

Mode of application:

Azithromycin is taken in tablet form once a day 1 hour before meals or 2 hours after a meal. With infections of the respiratory system 0, 5g a day, 3 days course of treatment. When infection of the soft tissue of the skin   - 1d in the first day, then 0, 5 g per day from the 2nd to the 50th day. Cervicitis, infections of the genitourinary system   - Once 1gramm. Borreliosis : 1gramm the first day followed by 4 days at 0, 5 grams. Ulcerative lesions of the gastrointestinal tract : Three days as part of 1gramm Helicobacter therapy . Pneumonia Intravenously 0, 5 grams, 1 times a day for at least 2 days and then transferred to a capsule form preparation Azithromycin: for 0, 5 g for a week.

Special instructions:

When receiving the pass it is recommended to take the drug as soon as possible, following reception - with an interval of 24 hours. Antacids should be taken at intervals of 2 hours.

Drug Interactions:

Food, ethanol, antacids decrease and slow absorption of the drug. Azithromycin enhance the anticoagulant effect of warfarin increases Digoxin . Dihydroergotamine . ergotamine   enhance the toxic effect develops dysesthesia . vasospasm . Azithromycin reduces the clearance, greatly enhances the pharmacological effect of triazolam, improves concentration, toxicity methylprednisolone . cycloserine , Anticoagulants, felodipine .   Chloramphenicol   and tetracycline   reinforce and lincosamides   weaken the effectiveness of the drug. Azithromycin pharmacologically incompatible with heparin.