Terbizil

Description overdue on 27.01.2012

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Antifungal agent . Terbizin is a broad spectrum antibiotic, belongs to a group of allylamines. Active, active substance is terbinafine . In low concentrations, the basic substance exhibits fungicidal effect, which are susceptible g riba dermatophytes   (Microsporum canis, Trychophyton rubrum, Epidermophyton floccosum et al.), Molds, and dimorphic fungi (Pityrosporum orbiculare). Against yeasts Terbizil and has fungicidal and fungistatic effect. Fungicidal effect is achieved by inhibiting the sterol synthesis in the cells, resulting in inhibition of production   ergosterol And this in turn causes the death of the microorganism. Additionally Terbizil causing inhibition of the enzyme squalene epoxidase . Squalene epoxidase is located in the cell membrane, and the violation of its work leads to an accumulation of squalene in the cell and the death of the fungus. For a man Terbizil a completely is not dangerous, so-as the in the cells of of the human organism terbinafine of such influence does not render. Terbizil produced in 2-forms for topical cream (1%, 1 g terbinafine contains 10 mg) and a tablet containing 125 or 250 mg terbinafine.

Indications:

Mycotic infections   skin and nail, skin diseases and hair scalp fungal origin ( onychomycosis . microsporia , Trichophytosis, athlete Candidiasis skin rubrofitii, mucosal candidiasis); pityriasis versicolor   (only used for topical application form).

Contraindications:

Absolute contraindications for prescribing Terbizil not, the only possible - increased sensitivity to terbinafine. Relative (to appoint Terbizil is necessary cautiously) contraindications: pathology of hepatic system and kidneys, accompanied by violation of functions of the authority and insufficiency. It is necessary to be careful in the presence of disease in the patient forming organs and endocrine diseases, cardiovascular and oncological diseases . No experimental evidence of the safety of terbinafine in pediatric practice, until the age of two drug use under strict indications. It is not necessary to appoint Terbizil breastfeeding, Bremen.

Side effect:

With a frequency of up to 10% are possible violations on the part of the digestive tract : Loss of appetite, nausea, diarrhea, pain in the epigastric region. Terbizil may cause allergic skin reactions (rash, hives). It is noted that in patients receiving the drug, pain in joints and muscles. Nervous system   may react to the drug dizziness. Can a headache. It is rare, but not excluded taste disturbances, up to complete its loss, stagnation in the hepato-duodenal area pankreo-( cholestatic jaundice ), A polymorphic exudative erythema, bullous dermatitis up to toxic epidermal necrolysis ( Lyell's syndrome ) There may be signs of depression forming organs function: agranulocytosis   and   thrombocytopenia , Lymphopenia or neutropenia. In a place of of application is not excluded the appearance of of itching and of a burning sensation of the skin, hyperemia .

Mode of application:

Duration of therapy in many respects determined by the character the disease and its the severity of. In pediatrics in the treatment of children, starting from the third year of life, the dosages of 125 mg, administered once (a day). Adults should apply the dosage of 250 mg is recommended to take the number Terbizila at once. When onychomycosis the duration of effective treatment - from six to twelve weeks, is determined by the rate of growth of healthy nail. Duration of treatment may be determined by other factors: age, presence of comorbidities. Terbizil used in the treatment Tinea pedis   (plantar, interdigital or the type of socks) - the duration of treatment from two to six weeks; in tinea other plots skin course of therapy continues from two to four weeks; diseases of the head mycotic etiology - 4 weeks. Terbizil cream is applied 1-2 times a day. It should be clean and dry before applying the lesions Terbizila. Distribute a thin layer of cream, capturing not only the lesion, but also the surrounding areas of healthy skin. When fungal infections involving diaper rash cream is recommended to cover the bandage.

Special instructions:

Patients with a pronounced oppression function hepatic system and kidneys dose of Terbizila should be to halve the. Overdose is very rare, the main symptoms: headache, sharp pain in the stomach, nausea, ringing in the ears and dizziness. Treatment is aimed at removing the drug from the body: it is necessary to wash out the stomach and give the patient Activated carbon   or other sorbents. Since Terbizil can influence the function of the liver, during the course of antifungal therapy must be controlled transaminases   (hepatic enzymes) in the plasma of the patient. Avoid Terbizila eyes. If you get recommended copious rinsing with running water.

Drug Interactions:

Terbizil affect the clearance of drugs metabolized by the system takes place P450   (tolbutamide, cycloserine , Oral contraceptives), and terbinafine may either accelerate or slow the metabolism of these drugs. Metabolism of Terbizila can accelerate substances that enhance the activity of microsomal enzymes of the liver cells ( rifampicin ). Drugs that inhibit the activity of the enzyme cytochrome P450, slow excretion of terbinafine, which requires adjusting the dose of the latter.