Description overdue on 08/09/2014
- Latin name: Niselat
- ATC code: M01AB
- Active substance: Amtolmetin guatsil (Amtolmetin guacil)
- Manufacturer: Dr. Reddy's Laboratories Ltd. (India)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Nayzilat
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In one tablet of the drug is contained amtolmetin guatsila 600 mg (active ingredient).
Auxiliary substances: monohydrate lactose, gipromelloza, colloidal dioxide silicon, carboxymethylstarch sodium, stearate magnesium.
The composition of the film-coating: hypromellose, titanium dioxide, macrogol 400.
Product form
Nayzilat represents tablets covered Sheath white color, in capsule form, Stock specific smell. 10 such tablets - in a blister pack, two such blisters - in a carton box.
Pharmacological action
It has analgesic, anti-inflammatory, desensitizing, analgesic, gastroprotective action.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics amtolmetina guatsila
NSAIDs, non-selective blocker cyclooxygenase , The predecessor tolmetin metabolic chain. Suppresses bonding Platelet ; blocks cyclooxygenase first and second types, alters metabolism arachidonic acid , Reduces the synthesis of prostaglandins It inhibits the exudative and the proliferative phase of the inflammatory process. Impairs the permeability of capillaries ; normalizes the lysosomal membranes; It slows down biosynthesis or inactivate inflammatory mediators ( histamine, prostaglandins, bradykinin, complement factors, cytokines ).
Blocks reaction bradykinin with tissue receptors, reduces pain in the inflammation. It has impact on thalamic centers that are responsible for pain sensitivity; reduces the content of biogenic amines exhibiting algogenic properties. It eliminates the intensity of pain, reduces morning stiffness, increase range of motion in the joints after four days of starting treatment. Protective effect amtolmetin guatsila on gastric mucosa is by activating receptors Capsaicin in the walls of the digestive tract. This is accompanied by an increase in the synthesis of nitric oxide and to counterbalance the negative effects of inhibition cyclooxygenase .
Pharmacokinetics
Absorption after administration usually rapid and complete. The drug accumulates in the walls of the digestive tract, where for 2 hours maintained its high concentration. Metabolized undergoing hydrolysis by esterases blood metabolites following form: MED5, guaiacol and tolmetin Turning into tolmetin (active metabolite), which has a pharmacological effect in tissues. Associated with the plasma protein by 99%. The half-life is 5 hours. After one day the drug completely excreted with urine (80%) and with bile (20%).
Indications
- osteoarthritis;
- rheumatoid arthritis;
- ankylosing spondylitis;
- bursitis;
- articular syndrome in gout;
- tenosynovitis;
- arthralgia;
- pain;
- myalgia;
- migraine;
- neuralgia;
- headache and toothache;
- tuberculosis,
- the pain at burns and traumas.
Contraindications
- Allergic to tolmetin, amtolmetin.
- Availability asthma , Allergy Aspirin or recurrent polyposis.
- Ulcerative lesions mucous of the stomach and 12-duodenal ulcer .
- Gastrointestinal bleeding in the active phase.
- Cerebrovascular bleeding .
- Bleeding disorders.
- Inflammatory bowel disease ( ulcerative colitis, Crohn's disease ) In the acute phase.
- Heart failure decompensated.
- Severe liver and kidney damage.
- Hypertension.
- The postoperative period coronary artery bypass surgery.
- Intolerance s lactose . deficit lactase, glucose-galactose malabsorption.
- Gestation and lactation .
- Age less than 18 years.
Be wary of:
- hyperbilirubinemia ;
- coronary heart disease ;
- chronic heart failure ;
- cerebrovascular diseases;
- diabetes;
- lesions of of peripheral arteries;
- chronic renal failure;
- in old age.
Side effects
- On the side digestive system Nausea, dyspepsia . diarrhea , Vomiting, constipation, peptic ulcer.
- On the side of the genitourinary system : Urinary tract infection.
- On the side of vision and hearing : Blurred vision, tinnitus.
- On the side Respiratory system : bronchospasm . rhinitis , Shortness of breath, swelling of the throat.
- On the side Nervous System : dizziness . drowsiness . depression .
- On the side circulatory system : Pressure rise.
- On the side hematopoietic system : anemia, thrombocytopenia, leukopenia.
- On the side skin : Rash, purpura . dermatitis . hives . Lyell's syndrome.
- Allergic reactions: anaphylactoid reactions.
Instructions on Nayzilat
Instructions for use Nayzilata prescribes take 600 mg 2 times a day. To save gastroprotective action drug should be used an empty stomach. The maximum daily dose - 1800 mg.
Overdose
Symptoms: nausea, abdominal pain, vomiting, metabolic acidosis . Treatment: gastric lavage perform to take Activated carbon , Spend symptomatic therapy.
Cooperation
The drug lowers the efficiency hypotensive, uricosuric and means diuretics .
Nayzilat enhances the action antiplatelet agents, fibrinolytic agents, anticoagulants , side effects estrogen, mineralocorticoid.
Kolestiramin and antacids reduce the absorption of Nayzilata.
Myelotoxicity funds increase gematotoksicheskim properties of the drug.
Terms of sale
The drug prescription.
Storage conditions
Keep away from children. Store at temperature until 25 degrees in dry dark place.
Shelf life
Two years.
Cautions
Drug treatment should be canceled for 48 hours prior to assay 17-ketosteroids . During therapy is recommended to refrain from dangerous activities that require attention and speed of reaction activities.
Analogs Nayzilata
Naklofen Duo
Olfen 100
Olfen-75
Neurodiclovit
Fanigan
Aertal
Indomethacin
Ortofen
Voltaren
Dikloberl
Ketanov
The drug is synthesized rather recently - analogues Nayzilata is not produced. Vimovo (a combination of NSAID and proton pump inhibitor) is the most similar in action with Nayzilatom.
Babies
The drug is contraindicated in persons under 18 years of age.
During pregnancy and lactation
The drug is contraindicated during pregnancy and breast-feeding .
Reviews about the Nayzilate
In general reviews of Nayzilate leave a positive mark, both in terms of therapeutic efficacy and in relation to the low frequency of side effects.
Price Nayzilata
In Russia, the price Nayzilata in standard packaging reaches 380 rubles, Ukraine, the average price Nayzilata 600 mg №20 is 63 hryvnia.
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