Tetracycline

Description overdue on 18.12.2011

Related Articles:

• Reviews of Depo-Provera
• Instructions on Atoxil bags for children
• Ingalipt during pregnancy
• Coldrex

Tweet

Antibacterial drugs has bacteriostatic effects   on sensitive microorganisms. Tetracycline is active against gram-positive, gram-negative flora, Rickettsia, Leptospira, spirochetes, agents of psittacosis, trachoma pathogens, Trichomonas , Amoebas. The drug is evenly distributed in all organs and tissues, it penetrates into the spinal, ascitic fluid, bile, synovial fluid. Tetracycline bad passes through   blood-brain barrier   (intact). Selective accumulation of the drug occurs in the spleen, liver, teeth, bones, tumor tissues. Good passes through the placenta completely passes into breast milk. Because the body is excreted in the feces, urine, bile intact. Cumulation   It occurs only when expressed violations of the renal system. It is produced in the form of capsules, in the form of tablets, ointments, eye ointments for external application.

Indications:

Tetracycline is prescribed for respiratory infections, bacterial lesions of the urinary tract, soft tissue infections, infections of the skin, necrotizing gingivostomatit , Acne, conjunctivitis, intestinal amebiasis , Actinomycosis, cholera, chancroid, Bartonella, brucellosis , Anthrax, inguinal granuloma, uncomplicated gonorrhea, chlamydia , Typhus, Rocky Mountain spotted fever, rickettsialpox, psittacosis , Plague, listeriosis, yaws, tularemia , Trachoma, syphilis , Relapsing fever,   typhus .

Contraindications:

Tetracycline is contraindicated to use fungal diseases, pregnancy, allergies, breastfeeding, expressed violations of the renal and hepatic systems. Not available in pediatrics before reaching the age of 8.

Side effect:

Hematopoietic system : hemolytic anemia , Thrombocytopenia, neutropenia. Nervous system : Dizziness, headache. Digestive system : glossitis , Dry mouth, constipation , Diarrhea, epigastric pain,   esophagitis , Anorexia, vomiting, nausea, tongue discoloration, increased levels of residual nitrogen, bilirubin, alkaline phosphatase, liver enzymes. Perhaps the development of allergies, photosensitivity , Thrush, intestinal dysbiosis .   vulvovaginal candidiasis , Hypovitaminosis B vitamins . The site of injection can be painful.

Mode of application:

Tablet form: adults 0, 25-0, 5 grams four times a day, or 0, 5-1 grams every 12 hours. The day may be receiving less than 4 grams of the drug tetracycline. Acne : 0, 5-2 grams per day in one to several doses. Melitensis   treated three weeks of 0, 5 grams of the drug every 6 hours., simultaneously injected intramuscularly streptomycin . Uncomplicated gonorrhea : Initial dosage of 1, 5 grams, after which it was reduced to 0, 5 grams taken every 6 hours for 4 days. Syphilis : The early stage of treatment lasts for 15 days, and 30 days later stage, every 6 hours take 0, 5 grams. Rectal infection, endocervical disease, uncomplicated urethral infections associated with Chlamidia trachomatis : Treatment 7 days, every 6 hours at 0, 5 grams. The ointment should be applied twice daily to the affected tissue.

Special instructions:

For the prevention of photosensitivity during treatment is recommended to avoid sun exposure. Long-term treatment requires regular monitoring of the work of hematopoiesis, hepatic system, renal system. Tetracycline with Ca 2+ forms stable complexes in kostnoobrazuyuschey tissue, which is manifested by staining tooth enamel in gray, yellow-brownish tint develops enamel hypoplasia . To prevent hypovitaminosis appoint brewer's yeast, vitamin B, Vitamin K .

Drug Interactions:

Tetracycline reduces prothrombin index   by suppressing the intestinal microflora, require lower dosages anticoagulants . Antibacterial drug reduces the effectiveness of microbicides, which the mechanism of action is based on infringement of cell wall synthesis (cephalosporins, penicillins). Tetracycline reduces the effectiveness of oral contraceptives estrogensoderjath, increases the risk of bleeding. At simultaneous reception with retinol there is an increase in intracranial pressure. Kolestiramin . antacids   reduce the absorption of the drug. Chymotrypsin   by increasing the concentration of drug in the blood increases the circulation time in the organism of tetracycline.