Beklazon

Description overdue on 10/13/2014

• Latin name: Beclazone
• ATC code: R03BA01
• Active substance: Beclomethasone (Beclometasone)
• Manufacturer: NORTON WATERFORD (Ireland)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Reviews
• Price, where to buy

Composition

1 comprises an aerosol dose of 50, 100 or 250 mg of active substance beclomethasone dipropionate . Excipients: hydrofluoroalkane and ethanol.

Product form

The spray is available in cans of aluminum, fitted with a special valve and dosing inhalation device with a cap-protector. The cylinders are designed for 200 doses and packed in cardboard boxes.

AT   Beklazon Eco Easy Breath   cans are in special aerosol inhalator which is activated by an active inhalation. The stack of cardboard is the optimizer and an inhaler with a balloon.

Pharmacological action

Inhaled glucocorticosteroid   having antiallergic and anti-inflammatory effects. The active ingredient prevents the release of neurotransmitters responsible for the inflammatory process; inhibits the process of synthesizing prostaglandins It reduces the amount of generated arachidonic acid , Enhances the production lipomodulina.

Slow infiltration and granulation is achieved by braking macrophages , Reducing the production of lymphokines and inflammatory exudate. The treatment can not restore the sensitivity of the patient to Bronchodilators That makes them much less.

The drug does not have mineralocorticoid effects. Active ingredient relaxes the smooth muscle of the bronchi, improving performance and reducing the external respiratory hyperreactivity bronchial tree. Beclomethasone reduces swelling of the epithelial cells, decreases mucus production of bronchial glands, reduces the number of mast cells in bronchial mucosa. Therapeutic doses Beklazon Eco do not cause systemic reactions common to most of glucocorticosteroids.

Intranasal inhalation can get rid of edema and hyperemia of mucous membranes of the nasal cavity. The therapeutic effect is recorded on the 5-day course of treatment.

Pharmacodynamics and pharmacokinetics

Part of a single dose that is deposited in the respiratory system after inhalation, absorbed lung tissue, wherein the active substance sufficiently rapidly hydrolyzed to form monoprorionata. Last hydrolyzed to beclomethasone.

A small part of the dose is swallowed and gets inside, but is inactivated in the liver system, after the first pass. The drug is metabolized by the liver to polar metabolites . The active component is capable of binding to plasma proteins to 87%.

Indications

Inhaled Beclomethasone is used in primary therapy asthma Especially in the absence of the effect of treatment with sodium cromoglycate and / or bronchodilators. The drug is prescribed for hormone-dependent form of bronchial asthma.

Intranasal drug prescribed for vasomotor rhinitis . hay fever . allergic rhinitis genesis .

Contraindications

Intranasal and inhaled use is contraindicated in:

• kandidomikoz   respiratory system;
• tuberculosis ;
• severe attacks of asthma;
• pregnancy   (I term);
• individual hypersensitivity   to the components.

Side effects

Respiratory tract:

• paradoxical bronchospasm ;
• cough;
• hoarseness;
• eosinophilic pneumonia ;
• throat irritation.

Intranasal application may develop oral candidiasis or perforation of the nasal septum . There are allergic responses :

• swelling of the lips, throat, face;
• erythema;
• hives ;
• itch .

Less registered System answers :

• stunted growth (in Pediatrics);
• osteoporosis ;
• dysfunction   the adrenal cortex;
• glaucoma ;
• cataract .

When registering other negative reactions require medical consultation and removal of the drug Beklazon.

Instructions for use (method and dosage)

The average dose inhalation administration - 400 mg / day. The number of inhalations per day - 2-4. The daily dose of beclomethasone can be increased up to 1 year Children appoint 50-100 mg.

Instructions for use Beklazon Eco nasally: 1-4 times a day with 100 mg.

Overdose

In acute overdose marked dysfunction of the adrenal cortex. After a few days the normal operation is restored adrenal independently, as evidenced by the level of Cortisol .

Chronic overdose of depressing job adrenal system, which requires the monitoring of redundant functions of the adrenal glands.

Cooperation

Other steroids combined with Beklazonom further depress the job adrenal system. Prior therapy with beta-agonists are inhaled can increase the effectiveness of the drug.

Terms of sale

Prescription medication.

Storage conditions

Do not freeze. Cylinders stored away from sunlight. The preferred temperature of - 30 degrees.

Shelf life

3 years.

Cautions

The drug is not intended for the relief (withdrawal symptoms) of acute attacks. The attending physician should be held explanatory conversation, reveal important aspects for patients prophylactic use of inhalers. The optimal therapeutic effect is achieved only with regular and proper use of medications.

Patients who used bronchodilators and have not reached the desired results, the improvement recorded within 1 week of application Beklazona.

In the transition from oral to inhaled corticosteroids forms need to be careful, because long-term therapy disrupts the adrenal system, and the recovery is quite slow. In some patients the abolition Steroids   there is a general malaise, although lung function is significantly increased. It is important to explain to patients that this is a temporary discomfort, and monitor the regularity of inhalation.

Analogs

Match code ATC 4th level:

• Fliksotid
• Budesonide
• Pulmicort
• Aldetsin

• Beklospir;
• Beklat;
• Maple.

Reviews Beklazone (opinion of doctors and patients)

The drug is widely prescribed by doctors, pulmonologists and allergists in the treatment of asthma. Practical release form makes it easy to daily drug use.

In discussion forums, patients leave their reviews about Beklazon Eco, indicating high efficacy and good tolerability. Patients describe the usability line "Easy breathing", which is carried out by means of active inhalation breath. Reviews Beklazon Eco Easy breathing only positive and do not cause doubt in the high quality of the drug.

Price Beklazona where to buy

In Russia, the price Beklazon Eco is 350 rubles (200 doses). Those who appreciate the ease of use, it is recommended to buy Beklazon Eco Easy breathing. The cost depends not only on the region's sales and pharmacy chain, but the dose of the active substance. Price Beklazon Eco Easy Breath of 250 micrograms in Moscow - 1000 rubles.

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