Thursday, August 10, 2017

Mebendazole

Description overdue on 20.03.2012

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 Mebendazole  Worming medication . Effective in trihotsefaleze . enterobioze . The principle of operation is based on permanent impairment of glucose utilization, leading to the depletion of glycogen reserves in the body of the parasite, inhibits synthesizing cellular tubulin , Slows down the process of synthesizing ATP. Mebendazole available in tablet form.

Indications and contraindications:

Mebendazole prescribed for ankilostomidoze, ascariasis, enterobioze, trihotsefaleze, strongiloidoze mixed helminthiasis, gnastomozah, capillariasis, Alveococcosis, multiple nematodes, echinococcosis, taeniasis, trichinosis. Mebendazole not prescribed for Crohn's disease , Breastfeeding, hypersensitive to the components, ulcerative colitis In Pediatrics up to two years, the pathology of the liver.

Side effect:

Epigastric pain, dizziness, allergic reactions, diarrhea, anemia, increased levels of liver enzymes, cylindruria, hematuria, hair loss, eosinophilia, vomiting, leukopenia, hypercreatininemia . The drug adversely affects fetal development.

Overdose:

Diarrhea, nausea, vomiting,   neutropenia , Hepatitis, liver toxicity. Requires gastric lavage, the use enterosorbents.

Mode of application:

Mebendazole taken by mouth, washed down with water. Enterobiasis - a single dose of 100 milligrams. With a high probability of secondary invasion appoint another 100 mg every 2-4 weeks. It is necessary to treat all members of the family, and exposed at the same time. Mixed helminth infections, strongyloidiasis, taeniasis, hookworm, trichuriasis, ascariasis: three days of 100 mg in the morning and evening.


Special instructions:

Long-term use of the drug mebendazole requires control over the state of the liver, renal system, peripheral blood. After taking the pill is unacceptable use of fatty foods, alcoholic beverages, use laxatives . After treatment, be sure to smear the anal region, feces. Worming treatment considered successful in the absence of helminth eggs themselves within 7 days after antiparasitic treatment.

Drug Interactions:

Mebendazole reduces the need for insulin in patients diabetes . Not recommended for use with lipophilic compounds. Inductors metabolism carbamazepine   reduce levels of the drug, and cimetidine increases the concentration of active substance in the blood.

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