Etatsizin

Description overdue on 06/11/2014

• Latin name: Ethacyzin
• ATC code: C01BC
• Active substance: Dietilaminopropioniletoksikarbonilaminofenotiazin (Diethylaminopropionyletoxycarbonylaminophenothiazine)
• Manufacturer: Olainfarm (Latvia)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use etatsizin (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The drug contains as active component hydrochloride dietilaminopropioniletoksikarbonilaminofenotiazina . In addition, it contains further constituents such as methyl cellulose . potato starch . calcium stearate . sugar .

The casing has the following components: calcium carbonate . colorant sunset yellow . sugar . quinoline yellow dye . Titanium dioxide . carnauba wax . magnesium carbonate basic . povidone . colloidal silicon dioxide .

Product form

The drug is sold in round or lenticular tablets are coated yellow.

Tablets are blisters that are contained in cardboard packs.

Pharmacological action

Etatsizin is antiarrhythmic   drug.

Pharmacodynamics and pharmacokinetics

This means inhibits the Na + channel and to a lesser extent, Ca + channels. It slows down the depolarization of the cell infarction . Decreases excitability of the conduction system . automatism . conduction of excitation   and excitability threshold . It has a moderately negative inotropic effect, as well as local anesthetic   effect.

The product is characterized by long antiarrhythmic   exposure. The duration of the effect can be reduced depending on the dosage.

The drug increases myocardial fibrillation threshold   and it does not cause elongation length QT interval on ECG As well as significant reduction in heart rate.

Antiarrhythmic   action at Oral   applying developing, usually after 1-2 days. The duration of treatment depends on the form Arrhythmia , Personal medication tolerability and effectiveness.

Etatsizin quickly absorbed   from the gastrointestinal tract. Maximum plasma concentration is reached after 150-180 minutes. The blood is determined after 30-60 minutes. Bioavailability   It is 40%. Most of the active substance is bound to plasma proteins (90%). The half-life - 2, 5 hours. However, the pharmacokinetics may individually vary. In some cases, it should be specially studied with the purpose of determining optimal plasma concentrations.

Etatsizin intensively processed in the liver. This produces metabolites   from antiarrhythmic   activity. Withdrawal of the drug through the kidneys in the form metabolites . Provided at Lactation   with breast milk. Able to penetrate placenta .

Indications

The drug is used in the following cases:

• paroxysmal supraventricular tachycardia ;
• fibrillation   and ondulyatsiya atria ;
• Ventricular   and supraventricular arrhythmias ;
• warning ventricular   and supraventricular arrhythmia .

Contraindications

Cardiac contraindications to the use of the following means:

• sharp Coronary Syndrome ;
• violation intraventricular conduction ;
• myocardial infarction ;
• expressed   hypotension ;
• expressed conduction disorders ;
• heart failure ;
• cardiomyopathy ;
• cardiosclerosis   after heart attack ;
• cardiogenic shock ;
• significant seredechnyh dilatation cavities ;
• heart rhythm disturbances combined with blockades of conduct His-Purkinje system ;
• ejection fraction   & lt; 40%.

In addition, Etatsizin is contraindicated in:

• significant violations of the liver and kidneys;
• childhood;
• hypersensitivity to its components;
• pregnancy ;
• breastfeeding.

With caution is prescribed for drug sick sinus syndrome . of benign prostatic hyperplasia prostate atrioventricular block   I level, significant violations of peripheral blood circulation, hepatic   and renal failure . angle-closure glaucoma . coronary heart disease . cardiomegaly , Electrolyte imbalance, chronic heart failure (I FC) bradycardia .

Side effects

Side effects with the use of medicines may be as follows:

• cardiovascular system - Stop sinus . decrease myocardial contractility , Violation intraventricular conduction , Decreasing coronary blood flow . atrioventricular block . arrhythmia ;
• nervous system - paresis of accommodation . headache , Staggering when walking or turning the head, dizziness . diplopia . drowsiness ;
• change indicators ECG   - Expansion QRS complex   and P wave Lengthening PQ interval ;
• Gastrointestinal - nausea.

After completion of the side effects are reduced or completely disappear after 3-4 days. When long-term therapy etatsizin adverse reactions are not amplified. They depend on the dosage. Most often seen in the appointment of the maximum dose of the drug.

Instructions for use etatsizin (method and dosage)

For those who are appointed Etatsizin, instructions for use states that it should take one tablet (50 mg) 2-3 times during the day. If necessary, the dosage may be increased to receive tablets of 50 mg four times a day or for a tablet of 100 mg three times during the day. To cupping of an attack   You can take two tablets of 50 mg once. Sometimes, experts advise to combine this tool with small doses beta-blockers .

Instructions for use etatsizin reported that the drug is taken orally , Regardless of the meal. In order to achieve a stable antiarrhythmic   the effect may be supporting course. At the same dosage chosen doctor individually.

Overdose

At the use of the drug may develop severe intoxication . It has the following effects: a marked reduction Blood Pressure   and myocardial contractility .   bradycardia Lengthening PR interval   and expansion QRS complex . asystole . dizziness . sinoatrialnaya   and atrioventricular block . headache Increase the amplitude T waves , Blurred vision, gastrointestinal disorders.

Symptomatic therapy. It should be borne in mind that the Ventricular tachycardia   It can not be used antiarrhythmic   drugs class IA and IC. To eliminate expansion QRS complex . hypotension .   bradycardia   Sodium bicarbonate can be used.

Cooperation

This tool can not be combined with other antiarrhythmic   IC and drugs IA class, as well as   MAO inhibitors .

When interacting with beta-blockers   may increase antiarrhythmic   effect, especially when Arrhythmia   due to increased physical activity or stress.

Terms of sale

The drug is sold by prescription.

Storage conditions

Keep Etatsizin should be dry and hidden from the world scene. Optimum temperature 30 ° C. Keep away from children.

Shelf life

Three years.

Analogs etatsizin

Match code ATC 4th level:

• Propanorm

Analogs etatsizin often can be found in pharmacies. They have the same mode of action, indications and contraindications, and that the drug in question. The most effective analogs etatsizin: Tiodaron . Multak . Amiodarone . Panangin . Asparkam . Ritmokard . Arrhythmias . Propanorm . Kordaron   and Amiokordin .

Reviews etatsizin

Etatsizin reviews cardiologists and patients receiving mostly positive. The forums is rare to find a negative opinion. If the effect of this drug someone evaluates negatively likely he simply manifested adverse reactions.

Reviews etatsizin indicate that the drug acts quickly and always helps to cope with the problem. It is often prescribed by cardiologists, especially if other drugs have not been effective. Reviews of patients reported that the drug not only has a beneficial effect on the heart and improves overall performance.

Price etatsizin where to buy

Price etatsizin in tablets of 50 mg, on average - 730 rubles. Price etatsizin in tablets of 50 mg in Ukraine, on average - 300 hryvnia.

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