Kodterpin

Description overdue on 11/28/2014

• Latin name: Codterpin
• ATC code: R05FA02
• Active substance: Codeine + Sodium bicarbonate + terpine (Codeine + Sodium hydrocarbonate + Therpinhydrate)
• Manufacturer: JSC "Interhim", Ukraine

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Tablets kodterpin, instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition kodterpin

The composition of one tablet kodterpin as active ingredients include:

• 8 mg - codeine ;
• 250 mg - sodium bicarbonate ;
• 250 mg - terpine .

Additional ingredients:

• potato starch;
• povidone;
• microcrystalline cellulose;
• croscarmellose sodium;
• calcium stearate.

Product form

The drug kodterpin (kodterpin IC) is available in tablet form. One package holds 10 tablets.

Pharmacological action

Antitussive, expectorant, analgesic.

Pharmacodynamics and pharmacokinetics

Kodterpin is a combination drug intended to oppression severe coughing and exhibiting expectorant and analgesic action.

Incoming in the drug phenanthrene alkaloid   - codeine Whereby downward pressure on the central to ashlevoy center has direct antitussive effect. Also, activating opioid receptors in the intestine, leads to the relaxation of   smooth muscle . spasm all sphincter and lower peristalsis . Exhibits analgesic activity, has a less pronounced than that of morphine respiratory suppression, rarely leads to nausea . constipation . vomiting and myositis . Receiving small doses of codeine does not affect the functionality ciliated epithelium   and   respiratory center It does not reduce secretion of the bronchi , Increases the effectiveness of drugs with hypnotic . analgesic and sedative action.

A distinctive feature of the action terpine   It is to enhance the secretory function of bronchial glands, which in its turn leads to an expectorant effect.

Because of bronchial secretions pH shift to the alkaline side, sodium bicarbonate reduces the viscosity of the sputum And to some extent activates motor function of the bronchioles   and ciliated epithelium . Blunts cough reflex   and facilitates the removal of airway mucous.

Maximum efficiency kodterpin after oral administration, is observed after 30-60 minutes and lasts for 2-6 hours.

For internal (oral) received all the active ingredients of the drug have good absorption from the digestive tract.

Due to the lipophilicity, codeine rapidly passes the blood-brain barrier and accumulates mainly in adipose tissue as well as in liver, lungs, spleen and kidneys, though a lesser extent. Excreted in the urine and bile.

Other active ingredients kodterpin - sodium bicarbonate   and Terpin hydrate displayed during a cough with bronchial secretions and urine.

Indications

Symptomatic treatment unproductive (dry) strong Cough   in patients older than 2 years, except by various reasons when respiratory diseases   and lung diseases Including bronchopneumonia . emphysema light Heavy bronchitis .

Contraindications

• hypersensitivity to one of the active ingredients or additional pills kodterpin;
• pulmonary insufficiency ;
• arterial hypotension severe;
• obstructive airways disease, including asthma   and other serious diseases;
• arrhythmia ;
• traumatic brain injury;
• epilepsy ;
• postoperative period after operations on the biliary tract ;
• severe pathological conditions of the liver and kidneys;
• alcoholism ;
• age up to 2 years;
• Parallel reception narcotic analgesics ;
• periods breast-feeding   and pregnancy .

Side effects

Digestive:

• weakening or loss of appetite;
• dyspepsia ;
• dryness of the mouth;
• nausea ;
• pain in the epigastric region;
• vomiting ;
• constipation .

The immune system:

• development of various allergic reactions , including angioedema ;

CNS:

• headache ;
• corestenoma and other visual disturbances;
• drowsiness ;
• sedation;
• confusion;
• convulsions ;
• dizziness ;
• dysphoria ;
• frequent mood changes;
• euphoria ;
• bronchospasm ;
• respiratory depression.

Cardiovascular system:

• tachycardia ;
• orthostatic hypotension ;
• heartbeat.

Skin:

• rash ;
• itch ;
• hives .

Urogenital:

• urinary retention ;
• spasm of the sphincter of the bladder.

Others:

• excessive sweating;
• hot flushes .

Consequences kodterpin use of high doses for long periods of time, are as Depending on development   (addiction) by type drug .

Tablets kodterpin, instructions for use

Instructions on kodterpin depending on age recommended oral tablets from ½ to 3 tablets per day. In connection with the possible development codeine-based Holding therapy for over 5 days, perhaps only on doctor's advice, and in minimal doses.

Overdose

Kodterpin drug overdose may be accompanied by: nausea . constipation . vomiting , Headaches, pupillary constriction , Disturbances in the coordination of the eyeballs, atony of the bladder , Heart rhythm disorder ( tachycardia . bradycardia etc.). It is also possible slowing of breathing, acute the suppression of the respiratory center , With the subsequent development cyanosis . drowsiness . In rare cases ode shku . pulmonary edema . apnea . convulsions . hypotension , Urinary retention, and collapse .

The initial steps are to treat overdose gastric lavage and reception Activated Carbon . The feasibility of these measures is limited to 60 minutes from the time of receiving higher doses of the drug. Subsequently, symptomatic therapy is recommended. If necessary, designate antibiotics and carry out bladder catheterization. In severe toxic symptoms hospitalization. Antidote Codeine is - Naloxone .

Cooperation

Parallel reception sorbents . enveloping and binders drugs can reduce the absorption of the drug ingredients.

Not recommended for concurrent use MAO inhibitors   kodterpin and, because of the possible development of depression or increased arousal. Admission kodterpin possible 14 days after cancellation MAO inhibitors .

Application Atropine and other anticholinergics It should be carried out with extreme caution.

Joint appointment antidiarrheal products ( Kaoline . Loperamide ) Increases the risk of severe constipation, which can cause intestinal obstruction.

Because of the possible antagonism should not be used simultaneously Domperidone and Metoclopramide .

Antihypertensive hypotensive drugs may enhance the effects.

Narcotic analgesics series   enhance the analgesic effect codeine , whereas Quinidine lowers it.

We observed a more pronounced respiratory depression   and increased Sedation kodterpin effect when taking in conjunction with ethanol . neuroleptics . anesthetics . tricyclic antidepressants , Sedatives and hypnotics, anxiolytics and antihistamines sedation.

Combined reception antagonists opium   ( Buprenorphine . Naltrexone . Naloxone ) Can lead to manifestations withdrawal .

In the treatment of colds opportunity to combine with the appointment kodterpin antibacterial drugs and bronchodilators .

Biotransformation codeine in the liver is inhibited at reception Chloramphenicol and Chloramphenicol That leads to enhancement of its action.

Kodterpin lowers plasma concentration Ciprofloxacin .

Cimetidine and Ritonavir increase the plasma content codeine .

Absorption Mexiletine reduced by the use kodterpin.

Large doses codeine reinforce the effects of Digoxin and other cardiac glycosides .

Terms of sale

To purchase kodterpin requires a doctor's prescription.

Storage conditions

Kodterpin drug should be stored out of reach of children place at ambient temperatures up to 25 ° C.

Shelf life

The packaging manufacturer, the drug may persist for 4 years.

Cautions

Kodterpin drug should be used with caution in these states:

• inflammatory   diseases of the digestive system Due to exposure codeine peristalsis, segmentation of the intestine and increase its tone;
• gallbladder disease states, including cholelithiasis ;
• liver disease;
• adrenocortical insufficiency ;
• hypothyroidism ;
• prostatic hypertrophy ;
• arterial hypotension ;
• convulsive conditions;
• pneumonia ;
• myasthenia ;
• asthma history;
• respiratory dysfunction in history;
• substance abuse .

With kidney disease   slows down codeine That is the reason for increasing the intervals between taking the tablets.

In elderly patients elimination and metabolism of codeine   It can be slowed down, and therefore justified the appointment of lower doses of the drug.

Kodterpin do not recommend to accept the threat of abortion or before birth .

During therapy, it is better not to manage transport and not to engage in work that requires caution.

When receiving kodterpin for a long time, there is a possibility codeine-based development .

Analogs

Match code ATC 4th level:

• Terpinkod
• Codelac

• Kodesan IC ;
• Glikodin ;
• Zedeks ;
• Tedein ;
• Codelac ;
• Terpinkod H .

Synonyms

• Terkodin ;
• Kodeterp ;
• Kodarin ;
• Kodepsin ;
• Terpinkod .

Babies

In minimal doses administered to children after reaching the age of two.

With alcohol

During the therapy, the use of alcoholic beverages is prohibited.

During pregnancy (and lactation)

Application during periods kodterpin breast-feeding   and pregnancy contraindicated.

Reviews

Tragically, reviews about kodterpin, as a means of getting rid of the strong   nonproductive cough Is lost in the mass of information relating to receiving the drug to obtain intoxicated   and its consequences. Video, feature articles, advice narcologists and Psychotherapists And simply cries for help of people crowd the specialized forums dedicated codeine-based   and methods of combating this disease. The problem drug addiction   has been and remains quite severe, especially when it comes to teenagers, who often are the most ardent consumers narcotic drugs So-called "wheels".

At this time, the peak codeine addiction Which occurred in the period OTC   the sale codeine preparations It was held, but all the same question: "How to jump from codeine", "how to throw the wheel to swallow," etc. They remain relevant and troubled both the drug narcotic drugs And their loved ones.

It is very difficult to answer the question of how to get rid of according to codeine , And other things Narcotic Substances . One person is enough willpower, others help Faith, the third specialized doctors. In any case, the problem of a particular Depending It must be addressed individually, with the involvement of all possible specialists and all available means. If people can not find their own way out of the situation, he would have to seek help from those people for whom the problem Addiction It becomes a specialization. The joint efforts of doctors: psychiatrist . psychotherapist . Psychologist and others, in many cases, can lead to getting rid of Depending And hence a normal fulfilling life.

Returning to the reviews of the antitussive   kodterpin preparation, it is worth noting that it is really quite efficient and brings investment even at very strong cough . Subject doses and recommendations for its use, dependence to codeine   It does not occur, so that at nezloupotreblenii, the medicament may be an effective and reliable tool.

Price kodterpin where to buy

Price kodterpin pharmacies in Ukraine varies, depending on the region, from 22 to 30 hryvnia per pack.

10 tablets kodterpin you can buy in Kiev for 25 hryvnia.

Get the best price and buy