Klabaks

Description overdue on 08/18/2014

• Latin name: Klabax and Klabax OD
• ATC code: J01FA09
• Active substance: Clarithromycin (Clarithromycin)
• Manufacturer: Ranbaxy Laboratories Limited (India)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Klabaks, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

As part of a single tablet Klabaksa may contain 250 or 500 mg. clarithromycin   (active pharmaceutically active substance). As auxiliary compounds in the formulation include such agents as: povidone, silicon dioxide, MCC, AC-DI-Sol (croscarmellose sodium), purified talc, magnesium stearate and stearic acid .

The film coating of the drug contains: giproloza, titanium dioxide, hypromellose, sorbitan monooleate, quinoline yellow lacquer N CI 47005, purified water and the talc, and propylene glycol.

The composition of the ink with which sign applied to the tablet include such substances as: r lazirovanny shellac, propylene glycol, black iron oxide, N-butyl alcohol, purified water and isopropyl alcohol.

The composition of one tablet Klabaksa OD prolonged action may include 500 mg. drug compound klaritrotsin And auxiliaries such as a hypromellose, povidone, magnesium stearate, silicon dioxide (colloidal) laktolozy monohydrate, talc and sodium stearyl fumarate.

The film coating of tablets Klabaks present OD 20N52875 Opadry yellow colorant (titanium dioxide, quinoline yellow, talc, hypromellose, vanillin, giproloza and propylene glycol).   The composition of the ink used for the application of labels include esterified shellac, ink Opacode-S-1-17734, black iron oxide, propylene glycol, ammonium hydroxide and methanol.

Product form

Klabaks produced in the form of tablets, coated with a special coating. In one carton contains typically 1, 3 blisters with 10 tablets of 250 mg. 1 or blister containing 10 tablets of 500 mg.

Klabaks ML is also available in tablet form. However, one pack of the drug is placed, usually one or two blisters of 5-7 tablets (500 mg.).

Pharmacological action

Both drugs have bactericidal, antibacterial and bacteriostatic activity and refer to the   group of antibiotics.

Pharmacodynamics and pharmacokinetics

These drugs are macrolides (eg antibiotics) that stand out for their broad spectrum of activity. Klabaks, as well as isolating Klabaks use in treating a large variety of   harmful microorganisms , eg,   Streptococcus agalactiae, Haemophilus influenzae, Bordetella pertussis, Toxoplasma gondii, Eubacterium spp., Legionella pneumophila, Clostridium perfringens and so on, which provoke the development of bacterial infections of the respiratory tract, skin and digestive tract.

Under the influence of the active compound contained in the chemical composition of drugs disrupt the synthesis of a protein harmful microorganisms, both in terms in vitro (from Latin "in glass", i.e., when tested outside of a living organism), and in vivo   (translated as "in vivo", ie tested on living organisms).

Thanks to its distinctive capabilities clarithromycin That is part of both drugs metabolized in the liver   with help cytochrome. Bioavailability   these drugs is about 50%. Even when taken regularly Klabaksa character metabolism , and cumulation drug in the body remains unchanged.

Clarithromycin   It binds approximately 70% of the proteins that make up the blood plasma, which allows to maintain optimum levels of the drug in the body. Approximately 40% of the drug excreted in the urine, and about 30% - by the intestine.

When oral medications 14 hydroxyclarithromycin , and to laritromitsin sufficiently rapidly penetrate fluids and tissues human body. It is noteworthy that the concentration of active drug compounds in serum   several times less than the tissues.

Indications

So, from what Klabaks (Klabaks OD) or helps in the treatment of any disease using the drug:

• upper respiratory tract infection Due to the negative impact Sensitive harmful microorganisms , eg, sinusitis, laryngitis, tonsillitis and pharyngitis ;
• infection Caused by harmful microorganisms such as:   Mycobacterium fortuitum, Mycobacterium intracellulare, Mycobacterium kansasii, Mycobacterium avium, and Mycobacterium chelonae;
• gastric ulcer ;
• infection Affecting soft tissue And furthermore, skin , eg, abrasions, wound infection, folliculitis and impetigo;
• lower respiratory tract infections ( pneumonia, bronchitis );
• duodenal ulcer Induced eradaktsiey Helicobacter pylori;
• MAI;
• chlamydia.

Contraindications

Both drugs have the following contraindications:

• porphyria;
• age up to 12 years;
• hypersensitivity   to the substances included in the preparation, as well as Antibiotic ;
• first trimester pregnancy ;
• abnormal liver function;
• application in the therapeutic treatment ergot derivatives   and other drugs such as Pomozidoma, terfenadine, astemizole and Tsizapridoma.

Side effects

Among the most common side effects of these drugs include the following ailments:   abdominal pain, nausea, dizziness, diarrhea, dispersion, colitis, taste disturbance, headaches,   and   increase in liver enzymes, insomnia, depression, tinnitus, disorientation and confusion.

During the use of drugs is extremely rare, but may occur and such side effects of drugs such as: paresthesia, jaundice, nephritis, rash on the skin, Stevens-Johnson syndrome, urticaria, anaphylactic shock, leukopenia, hallucinations, arrhythmia or ventricular tachycardia.

Klabaks, instructions for use (method and dosage)

Dosage, as, indeed, and the schedule of the drugs depends on the doctor's appointments that are based on the severity of the disease, as well as the state of health of the patient. The recommended average daily dose Klabaksa for adult patients is 500 mg., It can be doubled in the presence of acute medical necessity. Typically, a course of treatment is 6 to 14 days.

Children under 12 years is recommended to take 7, 5 mg. medicines 2 times a day for a maximum of 10 days.

If a patient renal failure   should be reduced twice the dosage. During the treatment of diseases caused by exposure to harmful Mycobacterium avium Recommended daily dosage equal to 2 mg. clarithromycin , The duration of treatment in this case can be up to 6 months.

Instructions for use Klabaksa OD

As adult patients and children 12 years of age can be taken orally at 500 mg. Preparation 1 times a day for a maximum of 14 days. Schedule of drugs, as well as its dosage can be adjusted by your doctor depending on the severity of the infection and the patient's state of health. For patients with impaired   kidney function   should reduce the recommended dose of the drug by 50%.

Overdose

In case of overdose may manifest symptoms such as: diarrhea, nausea, headache, vomiting, confusion.   To resolve the above ailments should Rinse Acorns to And stop taking the drug or reduce the dosage.

Cooperation

In order to avoid the increase in the blood compounds metabolized in the liver, both drugs should not be taken simultaneously with anticoagulants As well as drugs such as the Theophylline, cisapride, phenytoin, carbamazepine, triazole, rifabutin, midazolam, Digoxin,   and Cyclosporine   and ergot alkaloids.

In addition, there is information about the development   skeletal muscle necrosis   while taking drugs with Simvastatin and Lovastatin , that are inhibitors of hydroxymethylglutaryl-CoA reductase . When used together, clarithromycin Contained in the composition of drug and clearance of triazolam the probability of occurrence of such side effects as the last drug confusion and sleepiness   increases several times.

Terms of sale

Buy drugs only by prescription.

Storage conditions

Both drugs are included in List B, so they should be kept out of the reach of children, at a temperature no higher than 25 C.

Shelf life

2 years.

Cautions

When used drugs in the treatment of patients with diseases   liver Wearing a chronic nature, required to carry out continuous monitoring of the level of enzymes in the blood . It should be approached with particular attention to the dosage of drugs when used together drugs that are active metabolized by the liver .

In appointing these drugs should not forget about the so-called cross-resistance   some antibiotics Belonging to macrolides . On top of that long-term treatment Klabaksom patient may   superimposed infection Ie condition in which the body of the patient against the background of disease re-infected with the same malicious by the bacteria and microorganisms.

Analogs Klabaksa

Match code ATC 4th level:

• Klatsid
• Klatsid CP
• Rulid
• Fromilid
• Azitroks
• Hemomitsin
• Vilprafen
• Rovamycinum
• Roxithromycin
• Clarithromycin
• Azithromycin
• Midecamycin
• Sumamed

The main counterparts Klabaksa can be considered:

• Arvitsin;
• Binoklar;
• Clarithromycin-Verte;
• Klarbakt;
• Klabaks OD;
• Clarithromycin-Teva;
• Zimbaktar;
• Clarithromycin CP;
• Arvitsin retard;
• Clarithromycin-Protekh;
• Clarithromycin Pfizer;
• Seydon-Sanovel;
• Kispar;
• Clarithromycin;
• SR Clara;
• Klatsid;
• Klaritsit;
• Clarithromycin retard -OBL
• Romiklar;
• Fromilid uno;
• Arvitsin retard;
• Kriksan;
• Fromilid;
• Klerimed;
• Clarithromycin Zentiva;
• The coating unit;
• Klasine;
• Ekozitrin;
• Clarithromycin-OBL;
• Klaritrosin;
• Fromilid uno.

Babies

Due to the presence of a sufficiently large list of side effects, these drugs are not recommended for use in the treatment of children under the age of 12 years.

During pregnancy (and lactation)

The use of drugs in the I trimester pregnancy   is strictly prohibited. The preparations may further be assigned only when there is a strong medical need for their use. This means that the use of these medications may be warranted intended benefits to the mother, which will greatly exceed the potential negative effects on fetal development.

During the use of these medications, doctors recommend quitting breast-feeding .

Reviews Klabakse

People try out the efficiency of the data itself antibiotics Are mostly mixed reviews left on ML and Klabaks Klabaks. It's all about the side effects of medicines, which sometimes occur on the second day of treatment.

Most often, patients complain of dizziness, nausea and vomiting , and bitterness in Hg at . Thus, these drugs often do not even have time to sufficiently develop their distinctive medicinal properties, because the patients are forced to interrupt therapeutic treatment.

Price Klabaksa where to buy

Price Klabaksa ML depends on the form of the drug varies from 300 (packaging, blister 1, 7 tablets of 500 mg.) And 600 rubles (packaging, blister 2, 14 tablets of 500 mg.) For the packaging of the preparation.

Average price Klabaksa 500 mg. (packaging, blister 1, 5, 10 and 14 coated tablets) of 250, 350 and 600 rubles respectively.

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